Anti-diabetic activity and mineral elements evaluation of  Vernonia amygdalina leaves obtained from Malaysia

Abdurahman Nour

Makale detayları

Anti-diabetic activity and mineral elements evaluation of Vernonia amygdalina leaves obtained from Malaysia

Yazarlar:

Abdurahman Nour

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 3, pp.514-521

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347198

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Diabetes has been characterized by transmuted lipids, hyperglycemia, proteins, and carbohydrates metabolism that can affect the quality of life. Although there are quite several synthetic drugs used in managing this disease, however, due to their side effects, the use of natural sources is imperative. This study focused on the in-vitro inhibitory activity of Vernonia amygdalina leaf grown in Malaysia using both α-amylase and α-glucosidase assays. The quantities of mineral elements in the plant extracts through microwave-assisted and Soxhlet extraction methods were as well examined through inductively coupled plasma mass spectrometry ICP-MS analysis. The extract of V. amygdalina leaf showed the highest dose-dependent effect of 97.28 and 98.08 of inhibition at 1.0 mgmL having IC50 values of 0.51 mgmL and 0.49 mgmL against α-amylase and α-glucosidase enzymes, respectively. The inhibitory effects of the extract were higher than acarbose a standard drug. Moreover, the results showed that higher quantities of mineral elements potassium, magnesium, and calcium and a lesser quantity of chromium in the extracts through microwave-assisted extraction MAE indicate that the technique possesses a higher capacity in obtaining higher mineral nutrients over Soxhlet extraction and more anti-diabetic activity of the extract. Thus, the extract exhibited an effective anti-diabetic activity which implies that it potentially serves as a natural source for managing diabetes.

 Diabetes has been characterized by transmuted lipids, hyperglycemia, proteins, and carbohydrates metabolism that can affect the quality of life. Although there are quite several synthetic drugs used in managing this disease, however, due to their side effects, the use of natural sources is imperative. This study focused on the in-vitro inhibitory activity of Vernonia amygdalina leaf grown in Malaysia using both α-amylase and α-glucosidase assays. The quantities of mineral elements in the plant extracts through microwave-assisted and Soxhlet extraction methods were as well examined through inductively coupled plasma mass spectrometry ICP-MS analysis. The extract of V. amygdalina leaf showed the highest dose-dependent effect of 97.28 and 98.08 of inhibition at 1.0 mgmL having IC50 values of 0.51 mgmL and 0.49 mgmL against α-amylase and α-glucosidase enzymes, respectively. The inhibitory effects of the extract were higher than acarbose a standard drug. Moreover, the results showed that higher quantities of mineral elements potassium, magnesium, and calcium and a lesser quantity of chromium in the extracts through microwave-assisted extraction MAE indicate that the technique possesses a higher capacity in obtaining higher mineral nutrients over Soxhlet extraction and more anti-diabetic activity of the extract. Thus, the extract exhibited an effective anti-diabetic activity which implies that it potentially serves as a natural source for managing diabetes.

 Diabetes has been characterized by transmuted lipids, hyperglycemia, proteins, and carbohydrates metabolism that can affect the quality of life. Although there are quite several synthetic drugs used in managing this disease, however, due to their side effects, the use of natural sources is imperative. This study focused on the in-vitro inhibitory activity of Vernonia amygdalina leaf grown in Malaysia using both α-amylase and α-glucosidase assays. The quantities of mineral elements in the plant extracts through microwave-assisted and Soxhlet extraction methods were as well examined through inductively coupled plasma mass spectrometry ICP-MS analysis. The extract of V. amygdalina leaf showed the highest dose-dependent effect of 97.28 and 98.08 of inhibition at 1.0 mgmL having IC50 values of 0.51 mgmL and 0.49 mgmL against α-amylase and α-glucosidase enzymes, respectively. The inhibitory effects of the extract were higher than acarbose a standard drug. Moreover, the results showed that higher quantities of mineral elements potassium, magnesium, and calcium and a lesser quantity of chromium in the extracts through microwave-assisted extraction MAE indicate that the technique possesses a higher capacity in obtaining higher mineral nutrients over Soxhlet extraction and more anti-diabetic activity of the extract. Thus, the extract exhibited an effective anti-diabetic activity which implies that it potentially serves as a natural source for managing diabetes.

 Diabetes has been characterized by transmuted lipids, hyperglycemia, proteins, and carbohydrates metabolism that can affect the quality of life. Although there are quite several synthetic drugs used in managing this disease, however, due to their side effects, the use of natural sources is imperative. This study focused on the in-vitro inhibitory activity of Vernonia amygdalina leaf grown in Malaysia using both α-amylase and α-glucosidase assays. The quantities of mineral elements in the plant extracts through microwave-assisted and Soxhlet extraction methods were as well examined through inductively coupled plasma mass spectrometry ICP-MS analysis. The extract of V. amygdalina leaf showed the highest dose-dependent effect of 97.28 and 98.08 of inhibition at 1.0 mgmL having IC50 values of 0.51 mgmL and 0.49 mgmL against α-amylase and α-glucosidase enzymes, respectively. The inhibitory effects of the extract were higher than acarbose a standard drug. Moreover, the results showed that higher quantities of mineral elements potassium, magnesium, and calcium and a lesser quantity of chromium in the extracts through microwave-assisted extraction MAE indicate that the technique possesses a higher capacity in obtaining higher mineral nutrients over Soxhlet extraction and more anti-diabetic activity of the extract. Thus, the extract exhibited an effective anti-diabetic activity which implies that it potentially serves as a natural source for managing diabetes.

Makale detayları

Anti-diabetic activity and mineral elements evaluation of Vernonia amygdalina leaves obtained from Malaysia

Yazarlar:

Abdurahman Nour

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 3, pp.514-521

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347198

pISSN:

2630-6344

Mineral elements

Vernonia amygdalina

anti-diabetic activity

alpha-amylase

alpha-glucosidase

Sayı

Makale detayları

Anti-diabetic activity and mineral elements evaluation of Vernonia amygdalina leaves obtained from Malaysia

Yazarlar: Abdurahman Nour

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Biochemistry

Dergi: Journal of Research in Pharmacy Vol.23 Issue 3, pp.514-521

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347198

pISSN: 2630-6344

Mineral elements

Vernonia amygdalina

anti-diabetic activity

alpha-amylase

alpha-glucosidase

Sayı

Yazarlar:

Abdurahman Nour

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 3, pp.514-521

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347198

pISSN:

2630-6344