Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs)

Burcu Mesut; Yıldız Özsoy; Emine Meltem Ocak

Makale detayları

Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs)

Yazarlar:

Burcu Mesut | Yıldız Özsoy | Emine Meltem Ocak

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.715-727

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346237

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Atomoxetine hydrochloride is a selective norepinephrine reuptake inhibitor used for the treatment of attention deficithyperactivity disorder. Atomoxetine hydrochloride is available in the form of capsules and oral solutions, yet it has no orally disintegrating form due to its bitter taste. ODTs are formulated to disintegrate rapidly upon contact with saliva and enable oral administration without water or chewing and offer improved patient compliance and ease of administration. Appropriate taste masking has great importance for ODTs. In this study, developing a taste-masked ODT formulation containing atomoxetine hydrochloride produced using the wet granulation method was aimed. Formulations were designed by changing the granulation agent Hydroxypropylmethylcellulose HPMC, Gellan gum, Veegum, Polyethylene glycol PEG 20000P and active substance to granulation agent ratio 1:2, 1:3, 1:4. Each formulation was tested physically and chemically. According to the results, it was concluded that Gellan gum is more appropriate for use in ODTs for taste masking.

 Atomoxetine hydrochloride is a selective norepinephrine reuptake inhibitor used for the treatment of attention deficithyperactivity disorder. Atomoxetine hydrochloride is available in the form of capsules and oral solutions, yet it has no orally disintegrating form due to its bitter taste. ODTs are formulated to disintegrate rapidly upon contact with saliva and enable oral administration without water or chewing and offer improved patient compliance and ease of administration. Appropriate taste masking has great importance for ODTs. In this study, developing a taste-masked ODT formulation containing atomoxetine hydrochloride produced using the wet granulation method was aimed. Formulations were designed by changing the granulation agent Hydroxypropylmethylcellulose HPMC, Gellan gum, Veegum, Polyethylene glycol PEG 20000P and active substance to granulation agent ratio 1:2, 1:3, 1:4. Each formulation was tested physically and chemically. According to the results, it was concluded that Gellan gum is more appropriate for use in ODTs for taste masking.

 Atomoxetine hydrochloride is a selective norepinephrine reuptake inhibitor used for the treatment of attention deficithyperactivity disorder. Atomoxetine hydrochloride is available in the form of capsules and oral solutions, yet it has no orally disintegrating form due to its bitter taste. ODTs are formulated to disintegrate rapidly upon contact with saliva and enable oral administration without water or chewing and offer improved patient compliance and ease of administration. Appropriate taste masking has great importance for ODTs. In this study, developing a taste-masked ODT formulation containing atomoxetine hydrochloride produced using the wet granulation method was aimed. Formulations were designed by changing the granulation agent Hydroxypropylmethylcellulose HPMC, Gellan gum, Veegum, Polyethylene glycol PEG 20000P and active substance to granulation agent ratio 1:2, 1:3, 1:4. Each formulation was tested physically and chemically. According to the results, it was concluded that Gellan gum is more appropriate for use in ODTs for taste masking.

 Atomoxetine hydrochloride is a selective norepinephrine reuptake inhibitor used for the treatment of attention deficithyperactivity disorder. Atomoxetine hydrochloride is available in the form of capsules and oral solutions, yet it has no orally disintegrating form due to its bitter taste. ODTs are formulated to disintegrate rapidly upon contact with saliva and enable oral administration without water or chewing and offer improved patient compliance and ease of administration. Appropriate taste masking has great importance for ODTs. In this study, developing a taste-masked ODT formulation containing atomoxetine hydrochloride produced using the wet granulation method was aimed. Formulations were designed by changing the granulation agent Hydroxypropylmethylcellulose HPMC, Gellan gum, Veegum, Polyethylene glycol PEG 20000P and active substance to granulation agent ratio 1:2, 1:3, 1:4. Each formulation was tested physically and chemically. According to the results, it was concluded that Gellan gum is more appropriate for use in ODTs for taste masking.

Makale detayları

Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs)

Yazarlar:

Burcu Mesut | Yıldız Özsoy | Emine Meltem Ocak

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.715-727

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346237

pISSN:

2630-6344

Atomoxetine hydrochloride

attention deficit hyperactivity disorder

orally disintegrating tablets

tastemasking

wet granulation

Sayı

Makale detayları

Formulation development and evaluation of taste-masked atomoxetine hydrochloride orally disintegrating tablets (ODTs)

Yazarlar: Burcu Mesut | Yıldız Özsoy | Emine Meltem Ocak

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.25 Issue 5, pp.715-727

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346237

pISSN: 2630-6344

Atomoxetine hydrochloride

attention deficit hyperactivity disorder

orally disintegrating tablets

tastemasking

wet granulation

Sayı

Yazarlar:

Burcu Mesut | Yıldız Özsoy | Emine Meltem Ocak

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.715-727

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346237

pISSN:

2630-6344