ASSESSMENT OF ANTIHYPERTENSIVE DRUG INDAPAMIDE GENOTOXICITY IN HUMAN PERIPHERAL LYMPHOCYTES USING CHROMOSOMAL ABERRATION TEST

Ece Avuloğlu YILMAZ; Deniz YÜZBAŞIOĞLU; Fatma ÜNAL

Makale detayları

ASSESSMENT OF ANTIHYPERTENSIVE DRUG INDAPAMIDE GENOTOXICITY IN HUMAN PERIPHERAL LYMPHOCYTES USING CHROMOSOMAL ABERRATION TEST

Yazarlar:

Ece Avuloğlu YILMAZ | Deniz YÜZBAŞIOĞLU | Fatma ÜNAL

Yayıncı:

Engin TUTKUN

Dergi:

The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-182

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000835368

Sıklık:

Üç Aylık

eISSN:

2149-4711

pISSN:

2149-4711

Özet:

 


Indapamide is an
active ingredient of orally administered diuretic antihypertensive drug.
Genotoxicity data of indapamide are very limited and not detailed (in terms of
doses, treatment period etc.). The purpose of this study was to evaluate the
potential genotoxic effect of indapamide by using in vitro chromosomal
aberration test. For this purpose, peripheral blood obtained from two healthy
young donors, a man and a woman, was treated with four different concentrations
(18,75; 37,50; 75,00 and 100,00 µg/ml) of indapamide in culture conditions for
24 and 48 h. A negative, a solvent (%75 methanol) and a positive control
(mitomycin-C) were also applied for each treatment. According to these results,
indapamide did not affect the frequency of chromosomal aberrations in all the
concentrations and treatment periods. However, there is need to be done other
genotoxicity tests for this active ingredient to support these results. 

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Makale detayları

ASSESSMENT OF ANTIHYPERTENSIVE DRUG INDAPAMIDE GENOTOXICITY IN HUMAN PERIPHERAL LYMPHOCYTES USING CHROMOSOMAL ABERRATION TEST

Yazarlar: Ece Avuloğlu YILMAZ | Deniz YÜZBAŞIOĞLU | Fatma ÜNAL

Yayıncı: Engin TUTKUN

Dergi: The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-182

Belge Tipi: Makale

Yayın Tarihi: 2/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000835368

Sıklık: Üç Aylık

eISSN: 2149-4711

pISSN: 2149-4711

Sayı

Yazarlar:

Ece Avuloğlu YILMAZ | Deniz YÜZBAŞIOĞLU | Fatma ÜNAL

Yayıncı:

Engin TUTKUN

Dergi:

The Turkish Journal Of Occupational / Environmental Medicine and Safety 2017 Vol.Volume 2 Issue İssue 1 (1), pp.1-182

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000835368

Sıklık:

Üç Aylık

eISSN:

2149-4711

pISSN:

2149-4711