Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome

Buğra ÇETİN; Seda GÜLEÇ; Hüseyin GÜLEÇ; Özgür ULUTAŞ; Turgay İŞBİR

doi:https://doi.org/10.28982/josam.929820

Makale detayları

Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome

Yazarlar:

Buğra ÇETİN | Seda GÜLEÇ | Hüseyin GÜLEÇ | Özgür ULUTAŞ | Turgay İŞBİR

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

İnsan psikolojisi | Hastalıklar

Dergi:

Journal of Surgery and Medicine 2022 Vol.6 Issue 4, pp.428-431

Belge Tipi:

Makale

Yayın Tarihi:

3/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000497892

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.929820

Özet:

 

Background/Aim: Fibromyalgia syndrome (FMS) has been linked to a genetic background. Although there are conflicting results, it has been suggested that cytokines play a role in FMS etiology. Interleukin (IL)1β is a cytokine that has been linked to FMS symptoms and has been detected in the skin of FMS patients. We aimed to determine the possible relationship between IL1β -31 and IL1β -511 polymorphisms in FMS.
Methods: In this cross-sectional study, we included patients who were diagnosed with FMS according to the American College of Rheumatology classification criteria. IL1β -31 (rs 1143627) and IL1β -511 (rs 16944) polymorphism genotyping was conducted in FMS patients (n=33) and healthy controls (n=41) using real-time polymerase chain reaction (RT-PCR). 
Results: IL1β -511 variations in patients with FMS and control groups were significantly different (P=0.010). The frequency of the IL1β -511 heterozygote AG genotype was significantly higher in controls (P=0.028). Additionally, the frequency of the IL1β -511 wild type A allele was significantly higher in the control group (P=0.003). The IL1β -31 genotypes and allele frequencies were not significantly different between the groups.
Conclusion: The IL1β -511 wild type A allele could be a risk-reducing factor for FMS. The present study suggests that genetic variations of the IL1β gene could play an important role in FMS etiology.

Makale detayları

Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome

Yazarlar: Buğra ÇETİN | Seda GÜLEÇ | Hüseyin GÜLEÇ | Özgür ULUTAŞ | Turgay İŞBİR

Yayıncı: Fatih BAŞAK

Ana Başlıklar: İnsan psikolojisi | Hastalıklar

Dergi: Journal of Surgery and Medicine 2022 Vol.6 Issue 4, pp.428-431

Belge Tipi: Makale

Yayın Tarihi: 3/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000497892

Sıklık: Aylık

eISSN: 2602-2079

DOI: https://doi.org/10.28982/josam.929820

Sayı

Yazarlar:

Buğra ÇETİN | Seda GÜLEÇ | Hüseyin GÜLEÇ | Özgür ULUTAŞ | Turgay İŞBİR

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

İnsan psikolojisi | Hastalıklar

Dergi:

Journal of Surgery and Medicine 2022 Vol.6 Issue 4, pp.428-431

Belge Tipi:

Makale

Yayın Tarihi:

3/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000497892

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.929820