Neurological presentations of nutritional vitamin B12 deficiency in 42 breastfed infants in Southeast Turkey

Mustafa TAŞKESEN; Ahmet YARAMIŞ; Selahattin KATAR; Ayfer GÖZÜ PİRİNÇÇİOĞLU; Murat SÖKER

Makale detayları

Neurological presentations of nutritional vitamin B12 deficiency in 42 breastfed infants in Southeast Turkey

Yazarlar:

Mustafa TAŞKESEN | Ahmet YARAMIŞ | Selahattin KATAR | Ayfer GÖZÜ PİRİNÇÇİOĞLU | Murat SÖKER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 6, pp.1091-1096

Belge Tipi:

Makale

Yayın Tarihi:

5/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754533

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Nutritional vitamin B12 deficiency is common in developing and underdeveloped countries and has a wide variety of neurological presentations. The aim of this study was to evaluate the neurological characteristics and laboratory results of infants with vitamin B12 deficiency.    Materials and methods: A total of 42 infants were included in this study. All patients were evaluated for clinical, physical, and neurological abnormalities, and an attempt was made to obtain short-term neurologic follow-up.    Results: Of 42 patients, 24 (57%) were boys and 18 (43%) were girls. The average age at diagnosis was 13.04 ± 5.68 months. Most of these infants were breastfed only and born from mothers with inadequate animal-derived protein consumption. Hypotonia (100%), anorexia (92.8%), neurodevelopmental (85.7%), and social (80.9%) retardation were the most present symptoms in all infants.   Conclusion: Severe neurological and hematological findings may be found in children with vitamin B12 deficiency. Early diagnosis and treatment is crucial in cases of hematological complications and neurologic impairment. Neurologic impairment may be irreversible if the diagnosis is delayed beyond 12 months. We think that dietary management, such as nutritional support with vitamin B12 for the mothers during pregnancy and complementary food for infants, may prevent the neurological deficits and neurodevelopmental retardation.

 

Nutritional vitamin B12 deficiency is common in developing and underdeveloped countries and has a wide variety of neurological presentations. The aim of this study was to evaluate the neurological characteristics and laboratory results of infants with vitamin B12 deficiency.    Materials and methods: A total of 42 infants were included in this study. All patients were evaluated for clinical, physical, and neurological abnormalities, and an attempt was made to obtain short-term neurologic follow-up.    Results: Of 42 patients, 24 (57%) were boys and 18 (43%) were girls. The average age at diagnosis was 13.04 ± 5.68 months. Most of these infants were breastfed only and born from mothers with inadequate animal-derived protein consumption. Hypotonia (100%), anorexia (92.8%), neurodevelopmental (85.7%), and social (80.9%) retardation were the most present symptoms in all infants.   Conclusion: Severe neurological and hematological findings may be found in children with vitamin B12 deficiency. Early diagnosis and treatment is crucial in cases of hematological complications and neurologic impairment. Neurologic impairment may be irreversible if the diagnosis is delayed beyond 12 months. We think that dietary management, such as nutritional support with vitamin B12 for the mothers during pregnancy and complementary food for infants, may prevent the neurological deficits and neurodevelopmental retardation.

Makale detayları

Neurological presentations of nutritional vitamin B12 deficiency in 42 breastfed infants in Southeast Turkey

Yazarlar:

Mustafa TAŞKESEN | Ahmet YARAMIŞ | Selahattin KATAR | Ayfer GÖZÜ PİRİNÇÇİOĞLU | Murat SÖKER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 6, pp.1091-1096

Belge Tipi:

Makale

Yayın Tarihi:

5/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754533

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Neurological presentation

hypotonia

nutrition

vitamin B12 deficiency

infancy

Sayı

Makale detayları

Neurological presentations of nutritional vitamin B12 deficiency in 42 breastfed infants in Southeast Turkey

Yazarlar: Mustafa TAŞKESEN | Ahmet YARAMIŞ | Selahattin KATAR | Ayfer GÖZÜ PİRİNÇÇİOĞLU | Murat SÖKER

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2011 Vol.41 Issue 6, pp.1091-1096

Belge Tipi: Makale

Yayın Tarihi: 5/2011

Belge Dili: Türkçe

Document ID (Org No.): 2000754533

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Neurological presentation

hypotonia

nutrition

vitamin B12 deficiency

infancy

Sayı

Yazarlar:

Mustafa TAŞKESEN | Ahmet YARAMIŞ | Selahattin KATAR | Ayfer GÖZÜ PİRİNÇÇİOĞLU | Murat SÖKER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2011 Vol.41 Issue 6, pp.1091-1096

Belge Tipi:

Makale

Yayın Tarihi:

5/2011

Belge Dili:

Türkçe

Document ID (Org No.):

2000754533

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144