Prevention of Intraabdominal Adhesions: An Experimental Study Using Mitomycin-C and 4% Icodextrin

Murat URKAN; İsmail Hakkı ÖZERHAN; Aytekin ÜNLÜ; Mehmet Fatih CAN; Erkan ÖZTÜRK; Armağan GÜNAL; Gökhan YAĞCI

Makale detayları

Prevention of Intraabdominal Adhesions: An Experimental Study Using Mitomycin-C and 4% Icodextrin

Yazarlar:

Murat URKAN | İsmail Hakkı ÖZERHAN | Aytekin ÜNLÜ | Mehmet Fatih CAN | Erkan ÖZTÜRK | Armağan GÜNAL | Gökhan YAĞCI

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2017 Vol.34 Issue 1, pp.35-40

Belge Tipi:

Makale

Yayın Tarihi:

12/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000759294

Sıklık:

İki Aylık

pISSN:

2146-3123

Özet:

 

Background: Intraabdominal adhesions remain a significant cause of morbidity and mortality. Moreover, intraabdominal adhesions can develop in more than 50% of abdominal operations.   Aims: We compared the anti-adhesive effects of two different agents on postoperative adhesion formation in a cecal abrasion model.   Study Design: Experimental animal study.   Methods: Forty Wistar albino type female rats were anesthetized and underwent laparotomy. Study groups comprised Sham, Control, Mitomycin-C, 4% Icodextrin, and Mitomycin-C +4% Icodextrin groups. Macroscopic and histopathological evaluations of adhesions were performed.   Results: The frequencies of moderate and severe adhesions were significantly higher in the control group than the other groups. The mitomycin-C and Mitomycin-C +4% Icodextrin groups were associated with significantly lower adhesion scores compared to the control group and 4% Icodextrin group scores (p=0.002 and p=0.008, respectively). The adhesion scores of the Mitomycin-C group were also significantly lower than those of the 4% Icodextrin group (p=0.008).   Conclusion: Despite its potential for bone marrow toxicity, Mitomycin-C seems to effectively prevent adhesions. Further studies that prove an acceptable safety profile relating to this promising anti-adhesive agent are required before moving into clinical trials.

Makale detayları

Prevention of Intraabdominal Adhesions: An Experimental Study Using Mitomycin-C and 4% Icodextrin

Yazarlar: Murat URKAN | İsmail Hakkı ÖZERHAN | Aytekin ÜNLÜ | Mehmet Fatih CAN | Erkan ÖZTÜRK | Armağan GÜNAL | Gökhan YAĞCI

Yayıncı: Trakya University

Dergi: Balkan Medical Journal 2017 Vol.34 Issue 1, pp.35-40

Belge Tipi: Makale

Yayın Tarihi: 12/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000759294

Sıklık: İki Aylık

pISSN: 2146-3123

Sayı

Yazarlar:

Murat URKAN | İsmail Hakkı ÖZERHAN | Aytekin ÜNLÜ | Mehmet Fatih CAN | Erkan ÖZTÜRK | Armağan GÜNAL | Gökhan YAĞCI

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2017 Vol.34 Issue 1, pp.35-40

Belge Tipi:

Makale

Yayın Tarihi:

12/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000759294

Sıklık:

İki Aylık

pISSN:

2146-3123