A biomarker predicting unfavorable prognosis in malignant pleural mesothelioma: systemic immune–inflammation index

Hüsnü Baykal; Filiz Çimen

Makale detayları

A biomarker predicting unfavorable prognosis in malignant pleural mesothelioma: systemic immune–inflammation index

Yazarlar:

Hüsnü Baykal | Filiz Çimen

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.389-393

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286262

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aim: Malignant pleural mesothelioma MPM is an extremely mortal condition. Only a few prognostic biomarkers have been described for MPM. Our study looked into the association between patient survival and the Systemic Immune Inflammation Index SII. Material and Method: A total of 158 patients who were admitted to our hospital between January 2013 and December 2022, and had a histopathologically confirmed diagnosis of MPM were included in the study. Before treatment, hematological parameters and SII were determined. A Spearmans correlation analysis was performed to analyze the correlation of mean survival with hematological parameters. Results: The study involved 158 patients in all. 70 patients had a history of smoking, the median age was 63 years, the mean survival time was 15.3 months, and 57.6 of the participants were men. The epithelioid type 84.2 was the most prevalent histological subtype, and 29 patients had stage 4 illnesses. Of the participants, 84 had received chemotherapy, and 22 had received radiotherapy before. Among the 39 patients who had surgery, 5 had an extrapleural pneumonectomy. SII meansd was 1427.21207.3. The patients with stage 4 disease had significantly shorter survival p0.001. The patients who had surgery survived significantly longer p0.01. Hemoglobin Hb r:0.21, p:0.01 and Hematocrit Hct r:0.18, p:0.03 values showed weak positive correlations with mean survival. It was evident that mean survival got shorter as SII r:-0.17, p:0.04 and neutrophil-lymphocyte ratio NLR r:-0.19, p:0.02 values got higher. On the other hand, there was a strong positive association between mean survival and the lymphocyte-monocyte ratio LMR r:0.21, p:0.01. When the parameters that had statistically significant differences among the groups were taken as control variables and the statistical analysis was re-performed, it was found that Hgb and Hct values as well as NLR and LMR ratios lost their significant correlations with survival. However, the SII ratio was still negatively correlated with survival r:-0.16, p:0.04. Conclusion: Pretreatment SII is a noninvasive and easy-to-calculate biomarker that predicts the prognosis of MPM. It is negatively correlated with mean survival regardless of the tumor stage and surgical management.

 Aim: Malignant pleural mesothelioma MPM is an extremely mortal condition. Only a few prognostic biomarkers have been described for MPM. Our study looked into the association between patient survival and the Systemic Immune Inflammation Index SII. Material and Method: A total of 158 patients who were admitted to our hospital between January 2013 and December 2022, and had a histopathologically confirmed diagnosis of MPM were included in the study. Before treatment, hematological parameters and SII were determined. A Spearmans correlation analysis was performed to analyze the correlation of mean survival with hematological parameters. Results: The study involved 158 patients in all. 70 patients had a history of smoking, the median age was 63 years, the mean survival time was 15.3 months, and 57.6 of the participants were men. The epithelioid type 84.2 was the most prevalent histological subtype, and 29 patients had stage 4 illnesses. Of the participants, 84 had received chemotherapy, and 22 had received radiotherapy before. Among the 39 patients who had surgery, 5 had an extrapleural pneumonectomy. SII meansd was 1427.21207.3. The patients with stage 4 disease had significantly shorter survival p0.001. The patients who had surgery survived significantly longer p0.01. Hemoglobin Hb r:0.21, p:0.01 and Hematocrit Hct r:0.18, p:0.03 values showed weak positive correlations with mean survival. It was evident that mean survival got shorter as SII r:-0.17, p:0.04 and neutrophil-lymphocyte ratio NLR r:-0.19, p:0.02 values got higher. On the other hand, there was a strong positive association between mean survival and the lymphocyte-monocyte ratio LMR r:0.21, p:0.01. When the parameters that had statistically significant differences among the groups were taken as control variables and the statistical analysis was re-performed, it was found that Hgb and Hct values as well as NLR and LMR ratios lost their significant correlations with survival. However, the SII ratio was still negatively correlated with survival r:-0.16, p:0.04. Conclusion: Pretreatment SII is a noninvasive and easy-to-calculate biomarker that predicts the prognosis of MPM. It is negatively correlated with mean survival regardless of the tumor stage and surgical management.

 Aim: Malignant pleural mesothelioma MPM is an extremely mortal condition. Only a few prognostic biomarkers have been described for MPM. Our study looked into the association between patient survival and the Systemic Immune Inflammation Index SII. Material and Method: A total of 158 patients who were admitted to our hospital between January 2013 and December 2022, and had a histopathologically confirmed diagnosis of MPM were included in the study. Before treatment, hematological parameters and SII were determined. A Spearmans correlation analysis was performed to analyze the correlation of mean survival with hematological parameters. Results: The study involved 158 patients in all. 70 patients had a history of smoking, the median age was 63 years, the mean survival time was 15.3 months, and 57.6 of the participants were men. The epithelioid type 84.2 was the most prevalent histological subtype, and 29 patients had stage 4 illnesses. Of the participants, 84 had received chemotherapy, and 22 had received radiotherapy before. Among the 39 patients who had surgery, 5 had an extrapleural pneumonectomy. SII meansd was 1427.21207.3. The patients with stage 4 disease had significantly shorter survival p0.001. The patients who had surgery survived significantly longer p0.01. Hemoglobin Hb r:0.21, p:0.01 and Hematocrit Hct r:0.18, p:0.03 values showed weak positive correlations with mean survival. It was evident that mean survival got shorter as SII r:-0.17, p:0.04 and neutrophil-lymphocyte ratio NLR r:-0.19, p:0.02 values got higher. On the other hand, there was a strong positive association between mean survival and the lymphocyte-monocyte ratio LMR r:0.21, p:0.01. When the parameters that had statistically significant differences among the groups were taken as control variables and the statistical analysis was re-performed, it was found that Hgb and Hct values as well as NLR and LMR ratios lost their significant correlations with survival. However, the SII ratio was still negatively correlated with survival r:-0.16, p:0.04. Conclusion: Pretreatment SII is a noninvasive and easy-to-calculate biomarker that predicts the prognosis of MPM. It is negatively correlated with mean survival regardless of the tumor stage and surgical management.

 Aim: Malignant pleural mesothelioma MPM is an extremely mortal condition. Only a few prognostic biomarkers have been described for MPM. Our study looked into the association between patient survival and the Systemic Immune Inflammation Index SII. Material and Method: A total of 158 patients who were admitted to our hospital between January 2013 and December 2022, and had a histopathologically confirmed diagnosis of MPM were included in the study. Before treatment, hematological parameters and SII were determined. A Spearmans correlation analysis was performed to analyze the correlation of mean survival with hematological parameters. Results: The study involved 158 patients in all. 70 patients had a history of smoking, the median age was 63 years, the mean survival time was 15.3 months, and 57.6 of the participants were men. The epithelioid type 84.2 was the most prevalent histological subtype, and 29 patients had stage 4 illnesses. Of the participants, 84 had received chemotherapy, and 22 had received radiotherapy before. Among the 39 patients who had surgery, 5 had an extrapleural pneumonectomy. SII meansd was 1427.21207.3. The patients with stage 4 disease had significantly shorter survival p0.001. The patients who had surgery survived significantly longer p0.01. Hemoglobin Hb r:0.21, p:0.01 and Hematocrit Hct r:0.18, p:0.03 values showed weak positive correlations with mean survival. It was evident that mean survival got shorter as SII r:-0.17, p:0.04 and neutrophil-lymphocyte ratio NLR r:-0.19, p:0.02 values got higher. On the other hand, there was a strong positive association between mean survival and the lymphocyte-monocyte ratio LMR r:0.21, p:0.01. When the parameters that had statistically significant differences among the groups were taken as control variables and the statistical analysis was re-performed, it was found that Hgb and Hct values as well as NLR and LMR ratios lost their significant correlations with survival. However, the SII ratio was still negatively correlated with survival r:-0.16, p:0.04. Conclusion: Pretreatment SII is a noninvasive and easy-to-calculate biomarker that predicts the prognosis of MPM. It is negatively correlated with mean survival regardless of the tumor stage and surgical management.

Makale detayları

A biomarker predicting unfavorable prognosis in malignant pleural mesothelioma: systemic immune–inflammation index

Yazarlar:

Hüsnü Baykal | Filiz Çimen

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.389-393

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286262

pISSN:

2636-8579

Malignant pleural mesothelioma

systemic immune-inflammation index

prognosis

survival

Malignant pleural mesothelioma

systemic immune-inflammation index

prognosis

survival

Sayı

Makale detayları

Yazarlar: Hüsnü Baykal | Filiz Çimen

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.389-393

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286262

pISSN: 2636-8579

Sayı

Yazarlar:

Hüsnü Baykal | Filiz Çimen

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.389-393

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286262

pISSN:

2636-8579