Effect of Etidronate on Urinary Calcium/Creatinin Ratio in Postmenopausal Women: A Prospective, Randomized, Placebo Controlled Study

Şenol KÜÇÜK

Makale detayları

Effect of Etidronate on Urinary Calcium/Creatinin Ratio in Postmenopausal Women: A Prospective, Randomized, Placebo Controlled Study

Yazarlar:

Şenol KÜÇÜK

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.683-688

Belge Tipi:

Makale

Yayın Tarihi:

5/1999

Belge Dili:

İngilizce

Document ID (Org No.):

2000757815

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

There are both histomorphometric and nonhistomorphometric studies confirming that etidronate reduces bone   resorption. In this study, we have examined urinary Calcium/Creatinine ratio (uCA/Cr) as a biochemical marker of bone turnover to show the effectiveness of etidronate and whether it could be used as a follow-up parameter of treatment. Eighty-one postmenopausal women aged 40 to 65 included into the study to investigate the effects of etidronate on uCa/Cr in a prospective, randomised, placebo controlled clinical trial. All necessary criteria matched 81 women were divided into 3 groups at random, each group consisted of 27 patients. Prior to treatment, uCa/Cr was calculated   from all subjects 3 hours after drinking 1 liter of water in the morning. Twenty seven (33.3%) women were randomised to oral doses of etidronate (400 mg/day for two weeks followed by drug free period of 10 weeks), twenty seven women to etidronate (400 mg/day for two weeks) plus calcium (1000 mg/day) for the following 10 weeks and twenty seven women to placebo (Fe, 50 mg/day) for 12 weeks. After 12 weeks of treatment, uCa/Cr declined significantly in the etidronate group from 0.118±0.064 to 0.053±0.021, in etidronate+calcium group from 0.08±0.03 to 0.06±0.015 ((p=0.004) and (p=0.005), respectively). In the placebo group no significant change was observed (p=0.03). In conclusion, etidronate is   effective in postmenopausal women and the effectiveness of treatment may be followed up by measuring uCa/Cr which is a simple and cheap parameter of determining the effectivensess of etidronate in prevention of osteoporosis. However, since there are contradictory findings concerning uCa/Cr exist, larger clinical and prospective studies should be carried out.

 

There are both histomorphometric and nonhistomorphometric studies confirming that etidronate reduces bone   resorption. In this study, we have examined urinary Calcium/Creatinine ratio (uCA/Cr) as a biochemical marker of bone turnover to show the effectiveness of etidronate and whether it could be used as a follow-up parameter of treatment. Eighty-one postmenopausal women aged 40 to 65 included into the study to investigate the effects of etidronate on uCa/Cr in a prospective, randomised, placebo controlled clinical trial. All necessary criteria matched 81 women were divided into 3 groups at random, each group consisted of 27 patients. Prior to treatment, uCa/Cr was calculated   from all subjects 3 hours after drinking 1 liter of water in the morning. Twenty seven (33.3%) women were randomised to oral doses of etidronate (400 mg/day for two weeks followed by drug free period of 10 weeks), twenty seven women to etidronate (400 mg/day for two weeks) plus calcium (1000 mg/day) for the following 10 weeks and twenty seven women to placebo (Fe, 50 mg/day) for 12 weeks. After 12 weeks of treatment, uCa/Cr declined significantly in the etidronate group from 0.118±0.064 to 0.053±0.021, in etidronate+calcium group from 0.08±0.03 to 0.06±0.015 ((p=0.004) and (p=0.005), respectively). In the placebo group no significant change was observed (p=0.03). In conclusion, etidronate is   effective in postmenopausal women and the effectiveness of treatment may be followed up by measuring uCa/Cr which is a simple and cheap parameter of determining the effectivensess of etidronate in prevention of osteoporosis. However, since there are contradictory findings concerning uCa/Cr exist, larger clinical and prospective studies should be carried out.

Makale detayları

Effect of Etidronate on Urinary Calcium/Creatinin Ratio in Postmenopausal Women: A Prospective, Randomized, Placebo Controlled Study

Yazarlar:

Şenol KÜÇÜK

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.683-688

Belge Tipi:

Makale

Yayın Tarihi:

5/1999

Belge Dili:

İngilizce

Document ID (Org No.):

2000757815

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Etidronate

urinary Calcium/Creatinin ratio

Hormone replacement therapy.

Sayı

Makale detayları

Effect of Etidronate on Urinary Calcium/Creatinin Ratio in Postmenopausal Women: A Prospective, Randomized, Placebo Controlled Study

Yazarlar: Şenol KÜÇÜK

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.683-688

Belge Tipi: Makale

Yayın Tarihi: 5/1999

Belge Dili: İngilizce

Document ID (Org No.): 2000757815

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Etidronate

urinary Calcium/Creatinin ratio

Hormone replacement therapy.

Sayı

Yazarlar:

Şenol KÜÇÜK

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 6, pp.683-688

Belge Tipi:

Makale

Yayın Tarihi:

5/1999

Belge Dili:

İngilizce

Document ID (Org No.):

2000757815

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144