The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke

Gönül Akdağ; Emine Saygın Uysal; Mustafa Çetiner; Muhammed Alperen Bardakçı; Niyazi Uysal; Merve Yatmazoğlu Çetin; Dursun Ceylan; Fatma Akkoyun Arıkan; Sibel Canbaz Kabay

Makale detayları

The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke

Yazarlar:

Gönül Akdağ | Emine Saygın Uysal | Mustafa Çetiner | Muhammed Alperen Bardakçı | Niyazi Uysal | Merve Yatmazoğlu Çetin | Dursun Ceylan | Fatma Akkoyun Arıkan | Sibel Canbaz Kabay

Yayıncı:

Sakarya University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Sakarya Tıp Dergisi Vol.14 Issue 4, pp.334-343

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001334111

pISSN:

2146-409X

Anahtar kelimeler:

Özet:

 Objective: This study aims to investigate the effect of routine laboratory parameters on clinical outcomes in patients with acute ischemic stroke AIS. Materials and Methods: Our study was designed as retrospective and cross-sectional. 94 patients with AIS who received inpatient treatment in our clinic with a diagnosis of acute ischemic stroke were included in the study. Laboratory data, demographic, and clinical characteristics were recorded at the time of admission. Neurological disabilities of the patients 3 months after treatment were evaluated with the modified Rankin Scale mRS. mRS 0-2 was considered a good prognosis and mRS 3-6 was considered a poor prognosis. Results: Of the 94 patients included in the study, 47 were men and 47 were women. The mean age was 71.1811.92 years. Laboratory parameters hemoglobin, eosinophil, totalcholesterol, ldl-cholesterol, and triglyceride values were significantly lower in the group with mRS3. As a result of ROC analysis, the area under the curve of hemoglobin, eosinophil, total-cholesterol, ldl-cholesterol, and triglyceride was significantly higherAUC: 0.710 95CI: 0.60-0.81; Sensitivity67.6, Specificity67.9, p0.001. In the multivariable logistic regression model, only the NIHSS score National Institutes Of Health Stroke Scale Scores was independently associated with the degree of disability p0.001. NIHSS is an independent factor in predicting stroke outcomes. Conclusion: It was determined that there was a significant inverse relationship between the routine laboratory parameters hemoglobin level, eosinophil level, LDL and total cholesterol levels, and infarct volume with the NIHSS scores of hemoglobin and LDLcholesterol.

 Objective: This study aims to investigate the effect of routine laboratory parameters on clinical outcomes in patients with acute ischemic stroke AIS. Materials and Methods: Our study was designed as retrospective and cross-sectional. 94 patients with AIS who received inpatient treatment in our clinic with a diagnosis of acute ischemic stroke were included in the study. Laboratory data, demographic, and clinical characteristics were recorded at the time of admission. Neurological disabilities of the patients 3 months after treatment were evaluated with the modified Rankin Scale mRS. mRS 0-2 was considered a good prognosis and mRS 3-6 was considered a poor prognosis. Results: Of the 94 patients included in the study, 47 were men and 47 were women. The mean age was 71.1811.92 years. Laboratory parameters hemoglobin, eosinophil, totalcholesterol, ldl-cholesterol, and triglyceride values were significantly lower in the group with mRS3. As a result of ROC analysis, the area under the curve of hemoglobin, eosinophil, total-cholesterol, ldl-cholesterol, and triglyceride was significantly higherAUC: 0.710 95CI: 0.60-0.81; Sensitivity67.6, Specificity67.9, p0.001. In the multivariable logistic regression model, only the NIHSS score National Institutes Of Health Stroke Scale Scores was independently associated with the degree of disability p0.001. NIHSS is an independent factor in predicting stroke outcomes. Conclusion: It was determined that there was a significant inverse relationship between the routine laboratory parameters hemoglobin level, eosinophil level, LDL and total cholesterol levels, and infarct volume with the NIHSS scores of hemoglobin and LDLcholesterol.

 Objective: This study aims to investigate the effect of routine laboratory parameters on clinical outcomes in patients with acute ischemic stroke AIS. Materials and Methods: Our study was designed as retrospective and cross-sectional. 94 patients with AIS who received inpatient treatment in our clinic with a diagnosis of acute ischemic stroke were included in the study. Laboratory data, demographic, and clinical characteristics were recorded at the time of admission. Neurological disabilities of the patients 3 months after treatment were evaluated with the modified Rankin Scale mRS. mRS 0-2 was considered a good prognosis and mRS 3-6 was considered a poor prognosis. Results: Of the 94 patients included in the study, 47 were men and 47 were women. The mean age was 71.1811.92 years. Laboratory parameters hemoglobin, eosinophil, totalcholesterol, ldl-cholesterol, and triglyceride values were significantly lower in the group with mRS3. As a result of ROC analysis, the area under the curve of hemoglobin, eosinophil, total-cholesterol, ldl-cholesterol, and triglyceride was significantly higherAUC: 0.710 95CI: 0.60-0.81; Sensitivity67.6, Specificity67.9, p0.001. In the multivariable logistic regression model, only the NIHSS score National Institutes Of Health Stroke Scale Scores was independently associated with the degree of disability p0.001. NIHSS is an independent factor in predicting stroke outcomes. Conclusion: It was determined that there was a significant inverse relationship between the routine laboratory parameters hemoglobin level, eosinophil level, LDL and total cholesterol levels, and infarct volume with the NIHSS scores of hemoglobin and LDLcholesterol.

 Bu çalışmanın amacı akut iskemik inmeli Aİİ hastalarda rutin laboratuvar parametrelerinin klinik sonuçlar üzerine etkisini araştırmaktır. Çalışmamız, retrospektif ve kesitsel olarak tasarlanmıştır. Çalışmaya akut iskemik inme tanısı ile kliniğimizde yatarak tedavi gören 94 Aİİli hasta çalışmaya dahil edildi. Başvuru sırasındaki laboratuvar verileri, demografik ve klinik özellikler kaydedildi. Hastaların tedaviden 3 ay sonraki nörolojik özürlülükleri modifiye Rankin Skalası mRS ile değerlendiridi. Hastalar mRSna göre hastalar iki gruba ayrıldı. mRS 0-2 arası iyi prognoz ve mRS 3-6 arası kötü prognoz olarak kabul edildi. Çalışmaya alınan 94 hastanın 47si erkek, 47si kadındı. Yaş ortalamaları 71,18 11,92 yıl idi. Hipertansiyon, kalp yetmezliği ve atrial fibrilasyon görülme oranının kötü prognozlu grupta daha yüksek olduğu belirlendi sırasıyla; 84,2  46.4; p0,001, 21,1  5.4; p0,04, 50  26,8; p0,03. Laboratuvar parametrelerinden hemoglobin, eozinofil, total-kolesterol, ldl-kolesterol ve trigliserit değerleri mRS 3 olan grupta anlamlı olarak düşük idi. ROC analizi sonucu hemoglobin, eozinofil, total-kolesterol, ldl-kolesterol ve trigliseridin eğri altındaki alanı anlamlı olarak fazlaydı AUC: 0,710 95 GA: 0,60-0,81; Duyarlılık  67,6, Özgüllük  67,9, p0,001. Çok değişkenli lojistik regresyon modelinde yalnızca NIHSS skoru National Institues Of Health Stroke Scale Scores bağımsız olarak sakatlık derecesi ile ilişkilendirildi p0,001. İnme sonucunu öngörmede NIHSS bağımsız bir faktördür. Bu çalışmada rutin laboratuvar parametrelerinden hemoglobin düzeyi, eozinofil seviyesi, LDL ve total kolestrol düzeyleri ile infarkt hacmi arasında hemoglobin ve LDL-kolesterolün NIHSS skorları ile ters yönlü anlamlı bir ilişki olduğu belirlendi.

Makale detayları

The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke

Yazarlar:

Gönül Akdağ | Emine Saygın Uysal | Mustafa Çetiner | Muhammed Alperen Bardakçı | Niyazi Uysal | Merve Yatmazoğlu Çetin | Dursun Ceylan | Fatma Akkoyun Arıkan | Sibel Canbaz Kabay

Yayıncı:

Sakarya University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Sakarya Tıp Dergisi Vol.14 Issue 4, pp.334-343

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001334111

pISSN:

2146-409X

Acute ischemic stroke

Laboratory

Infarct volume

Clinical outcomeAkut iskemik inme

laboratuvar

infarkt hacmi

klinik sonuç

Sayı

Makale detayları

Yazarlar: Gönül Akdağ | Emine Saygın Uysal | Mustafa Çetiner | Muhammed Alperen Bardakçı | Niyazi Uysal | Merve Yatmazoğlu Çetin | Dursun Ceylan | Fatma Akkoyun Arıkan | Sibel Canbaz Kabay

Yayıncı: Sakarya University

Ana Başlıklar: Klinik Tıp Bilimleri (Diğer)

Dergi: Sakarya Tıp Dergisi Vol.14 Issue 4, pp.334-343

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001334111

pISSN: 2146-409X

Sayı

Yazarlar:

Gönül Akdağ | Emine Saygın Uysal | Mustafa Çetiner | Muhammed Alperen Bardakçı | Niyazi Uysal | Merve Yatmazoğlu Çetin | Dursun Ceylan | Fatma Akkoyun Arıkan | Sibel Canbaz Kabay

Yayıncı:

Sakarya University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Sakarya Tıp Dergisi Vol.14 Issue 4, pp.334-343

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001334111

pISSN:

2146-409X