The utility of apparent diffusion coefficient values in predicting liver fibrosis in chronic hepatitis B

Bora Aktaş

Makale detayları

The utility of apparent diffusion coefficient values in predicting liver fibrosis in chronic hepatitis B

Yazarlar:

Bora Aktaş

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.282-288

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286223

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aim: We aimed to determine the relationship between apparent diffusion coefficient ADC values obtained from diffusion-weighted images, histopathological fibrosis, and activity stages in patients with chronic hepatitis B infection. Material and Method: A total of 30 patients with chronic hepatitis B admitted to our hospital between September 2012 and June 2014 were included in the study. All patients underwent biopsy and abdomen MRI examination before the treatment. Diffusion examinations at five different b-values 50, 300, 500, 700, and 1000 smm2 were added to the abdominal MRI examination. Results: The hepatic ADC values at all b-values were negatively correlated with fibrosis stages p0.001 for all b-values. The ADC values at b-values 300 and 1000 were significantly lower in patient groups with histological activity indices 1 and higher compared to the patient group whose activity index was 0 at b-value 300 p0.034, and at b-value 1000 p0.027. The ADC values at b-values 50, 500 and 700 were not significantly in patient groups with histological activity indices 1 and higher compared to the patient group whose activity index was 0. Hepatic ADC was a significant predictor of stage 2 or greater and stage 3 or greater fibrosis, with sensitivity of 81-100 and 81-96 , and specificity of 84,2-100 and 100 ADC with all b values. Conclusion: The ADC values have high sensitivity and specificity in indicating liver fibrosis in chronic hepatitis B infection. We suggest that the addition of diffusion-weighted MR images into liver MRI examination might reduce the requirement for liver biopsies in patients with chronic hepatitis B.

 Aim: We aimed to determine the relationship between apparent diffusion coefficient ADC values obtained from diffusion-weighted images, histopathological fibrosis, and activity stages in patients with chronic hepatitis B infection. Material and Method: A total of 30 patients with chronic hepatitis B admitted to our hospital between September 2012 and June 2014 were included in the study. All patients underwent biopsy and abdomen MRI examination before the treatment. Diffusion examinations at five different b-values 50, 300, 500, 700, and 1000 smm2 were added to the abdominal MRI examination. Results: The hepatic ADC values at all b-values were negatively correlated with fibrosis stages p0.001 for all b-values. The ADC values at b-values 300 and 1000 were significantly lower in patient groups with histological activity indices 1 and higher compared to the patient group whose activity index was 0 at b-value 300 p0.034, and at b-value 1000 p0.027. The ADC values at b-values 50, 500 and 700 were not significantly in patient groups with histological activity indices 1 and higher compared to the patient group whose activity index was 0. Hepatic ADC was a significant predictor of stage 2 or greater and stage 3 or greater fibrosis, with sensitivity of 81-100 and 81-96 , and specificity of 84,2-100 and 100 ADC with all b values. Conclusion: The ADC values have high sensitivity and specificity in indicating liver fibrosis in chronic hepatitis B infection. We suggest that the addition of diffusion-weighted MR images into liver MRI examination might reduce the requirement for liver biopsies in patients with chronic hepatitis B.

 Aim: We aimed to determine the relationship between apparent diffusion coefficient ADC values obtained from diffusion-weighted images, histopathological fibrosis, and activity stages in patients with chronic hepatitis B infection. Material and Method: A total of 30 patients with chronic hepatitis B admitted to our hospital between September 2012 and June 2014 were included in the study. All patients underwent biopsy and abdomen MRI examination before the treatment. Diffusion examinations at five different b-values 50, 300, 500, 700, and 1000 smm2 were added to the abdominal MRI examination. Results: The hepatic ADC values at all b-values were negatively correlated with fibrosis stages p0.001 for all b-values. The ADC values at b-values 300 and 1000 were significantly lower in patient groups with histological activity indices 1 and higher compared to the patient group whose activity index was 0 at b-value 300 p0.034, and at b-value 1000 p0.027. The ADC values at b-values 50, 500 and 700 were not significantly in patient groups with histological activity indices 1 and higher compared to the patient group whose activity index was 0. Hepatic ADC was a significant predictor of stage 2 or greater and stage 3 or greater fibrosis, with sensitivity of 81-100 and 81-96 , and specificity of 84,2-100 and 100 ADC with all b values. Conclusion: The ADC values have high sensitivity and specificity in indicating liver fibrosis in chronic hepatitis B infection. We suggest that the addition of diffusion-weighted MR images into liver MRI examination might reduce the requirement for liver biopsies in patients with chronic hepatitis B.

 Aim: We aimed to determine the relationship between apparent diffusion coefficient ADC values obtained from diffusion-weighted images, histopathological fibrosis, and activity stages in patients with chronic hepatitis B infection. Material and Method: A total of 30 patients with chronic hepatitis B admitted to our hospital between September 2012 and June 2014 were included in the study. All patients underwent biopsy and abdomen MRI examination before the treatment. Diffusion examinations at five different b-values 50, 300, 500, 700, and 1000 smm2 were added to the abdominal MRI examination. Results: The hepatic ADC values at all b-values were negatively correlated with fibrosis stages p0.001 for all b-values. The ADC values at b-values 300 and 1000 were significantly lower in patient groups with histological activity indices 1 and higher compared to the patient group whose activity index was 0 at b-value 300 p0.034, and at b-value 1000 p0.027. The ADC values at b-values 50, 500 and 700 were not significantly in patient groups with histological activity indices 1 and higher compared to the patient group whose activity index was 0. Hepatic ADC was a significant predictor of stage 2 or greater and stage 3 or greater fibrosis, with sensitivity of 81-100 and 81-96 , and specificity of 84,2-100 and 100 ADC with all b values. Conclusion: The ADC values have high sensitivity and specificity in indicating liver fibrosis in chronic hepatitis B infection. We suggest that the addition of diffusion-weighted MR images into liver MRI examination might reduce the requirement for liver biopsies in patients with chronic hepatitis B.

Makale detayları

The utility of apparent diffusion coefficient values in predicting liver fibrosis in chronic hepatitis B

Yazarlar:

Bora Aktaş

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.282-288

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286223

pISSN:

2636-8579

Apparent Diffusion Coefficient Value

diffusion MRI

hepatitis B

fibrosis

liver

MRI

Sayı

Makale detayları

The utility of apparent diffusion coefficient values in predicting liver fibrosis in chronic hepatitis B

Yazarlar: Bora Aktaş

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.282-288

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286223

pISSN: 2636-8579

Apparent Diffusion Coefficient Value

diffusion MRI

hepatitis B

fibrosis

liver

MRI

Sayı

Yazarlar:

Bora Aktaş

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 2, pp.282-288

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286223

pISSN:

2636-8579