Lack of association between TLR4 polymorphism and severe gram-negative bacterial infection in neonates

Tuba TURUL ÖZGÜR

Makale detayları

Lack of association between TLR4 polymorphism and severe gram-negative bacterial infection in neonates

Yazarlar:

Tuba TURUL ÖZGÜR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.423-427

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000755449

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Aim: Gram-negative microorganisms are responsible for a significant percentage of systemic bacterial infections in neonates, which tend to progress to sepsis. Toll-like receptor 4 (TLR4), one of the receptors in the innate immune system, binds to the lipopolysaccharide (LPS) present on gram-negative bacteria. Following ligation, a cascade of cellular signals leads to activation of NFkB, resulting in the generation of such proinflammatory cytokines as TNFa, IL-1, IL-2, and IL-6. These are the mediators of inflammation, which is the cellular response to activation of the innate immune system. As such, TLR4 appears to be a very likely candidate involved in the immediate immune response to gram-negative bacteria. Two polymorphisms in the TLR4 gene, Asp299Gly and Thr399Ile, cause a reduction in inflammatory cytokine response to LPS. We sought to determine if there was any correlation between these polymorphisms and severe gram-negative infection in neonates.   Materials and Methods: The study included 17 neonates with severe gram-negative infection and 70 healthy controls.   Results: No polymorphism was noted in the patient group. In all, 4 Asp299Gly and 7 Thr399Ile heterozygous polymorphisms were observed in the control group, and 4 subjects had both polymorphisms.   Conclusion: There appeared to be no correlation between the 2 polymorphisms-Asp299Gly and Thr399Ile- and gram-negative infection.

 

Aim: Gram-negative microorganisms are responsible for a significant percentage of systemic bacterial infections in neonates, which tend to progress to sepsis. Toll-like receptor 4 (TLR4), one of the receptors in the innate immune system, binds to the lipopolysaccharide (LPS) present on gram-negative bacteria. Following ligation, a cascade of cellular signals leads to activation of NFkB, resulting in the generation of such proinflammatory cytokines as TNFa, IL-1, IL-2, and IL-6. These are the mediators of inflammation, which is the cellular response to activation of the innate immune system. As such, TLR4 appears to be a very likely candidate involved in the immediate immune response to gram-negative bacteria. Two polymorphisms in the TLR4 gene, Asp299Gly and Thr399Ile, cause a reduction in inflammatory cytokine response to LPS. We sought to determine if there was any correlation between these polymorphisms and severe gram-negative infection in neonates.   Materials and Methods: The study included 17 neonates with severe gram-negative infection and 70 healthy controls.   Results: No polymorphism was noted in the patient group. In all, 4 Asp299Gly and 7 Thr399Ile heterozygous polymorphisms were observed in the control group, and 4 subjects had both polymorphisms.   Conclusion: There appeared to be no correlation between the 2 polymorphisms-Asp299Gly and Thr399Ile- and gram-negative infection.

Makale detayları

Lack of association between TLR4 polymorphism and severe gram-negative bacterial infection in neonates

Yazarlar:

Tuba TURUL ÖZGÜR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.423-427

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000755449

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Neonate

TLR4

gram-negative infections

Sayı

Makale detayları

Lack of association between TLR4 polymorphism and severe gram-negative bacterial infection in neonates

Yazarlar: Tuba TURUL ÖZGÜR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.423-427

Belge Tipi: Makale

Yayın Tarihi: 2/2009

Belge Dili: Türkçe

Document ID (Org No.): 2000755449

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Neonate

TLR4

gram-negative infections

Sayı

Yazarlar:

Tuba TURUL ÖZGÜR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.423-427

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000755449

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144