Investigation of relationship between nesfatin's, chemerin's, apelin's levels and insulin resistance and metabolic syndrome in Polycystic Ovary Syndrome patients

Ömer Ünal; Ozan Karadeniz; Zehra Kurdoglu

Makale detayları

Investigation of relationship between nesfatin's, chemerin's, apelin's levels and insulin resistance and metabolic syndrome in Polycystic Ovary Syndrome patients

Yazarlar:

Ömer Ünal | Ozan Karadeniz | Zehra Kurdoglu

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Health Care Administration

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 2, pp.284-289

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293721

pISSN:

1309-4483

Anahtar kelimeler:

Özet:

 Polycystic ovary syndrome PCOS is one of the most common gynecological endocrinopathies. In the literature, many studies support the involvement of IR insulin resistance and some adipokines in the pathophysiology of PCOS. In our study, we aimed to investigate the relationships of apelin, chemerin, nesfatin, IR, and MS metabolic syndrome to help clarify the pathophysiology of PCOS. We included 120 people in our prospective cohort study. We divided these 120 cases into three equal groups: a control group of healthy participants and two case groups of participants suffering from PCOS with a BMI below 30 and above 30. We conducted this study in a tertiary hospital between January 2014 and July 2014. We investigated the study groups in terms of demographic information, biochemical values, hormonal parameters, apelin, chemerin, and nesfatin values, and the relationships between MS and IR. Apelin, chemerin, and nesfatin values were 0.2330.027 ngdl, 232.79221.87 ngdl, and 2.111.27 ngdl in the control group. These values were 0.3040.093 ngdl, 313.57379.04 ngdl, and 0.850.91 ngdl in the nonobese PCOS patient group, respectively. The same parameters were 0.3040.093 ngdl, 344.31386.23 ngdl, and 0.741.42 ngdl in the obese PCOS patient group. The HOMA-IR values of the groups were 1.79  0.68, 3.61  5.45, and 4.58  4.39, respectively. The distribution of cases diagnosed with MS within the groups was 0, 10, and 17.5, respectively. We compared all these statistically significant results p0.005. The fact that blood nesfatin levels are significantly lower and apelin and chemerin levels are significantly higher in PCOS patients suggests that the synthesis and secretion of these adipokines are effective in the mechanism of the disease. The development of MS. Comprehensive prospective studies are needed to clarify this situation.

 Polycystic ovary syndrome PCOS is one of the most common gynecological endocrinopathies. In the literature, many studies support the involvement of IR insulin resistance and some adipokines in the pathophysiology of PCOS. In our study, we aimed to investigate the relationships of apelin, chemerin, nesfatin, IR, and MS metabolic syndrome to help clarify the pathophysiology of PCOS. We included 120 people in our prospective cohort study. We divided these 120 cases into three equal groups: a control group of healthy participants and two case groups of participants suffering from PCOS with a BMI below 30 and above 30. We conducted this study in a tertiary hospital between January 2014 and July 2014. We investigated the study groups in terms of demographic information, biochemical values, hormonal parameters, apelin, chemerin, and nesfatin values, and the relationships between MS and IR. Apelin, chemerin, and nesfatin values were 0.2330.027 ngdl, 232.79221.87 ngdl, and 2.111.27 ngdl in the control group. These values were 0.3040.093 ngdl, 313.57379.04 ngdl, and 0.850.91 ngdl in the nonobese PCOS patient group, respectively. The same parameters were 0.3040.093 ngdl, 344.31386.23 ngdl, and 0.741.42 ngdl in the obese PCOS patient group. The HOMA-IR values of the groups were 1.79  0.68, 3.61  5.45, and 4.58  4.39, respectively. The distribution of cases diagnosed with MS within the groups was 0, 10, and 17.5, respectively. We compared all these statistically significant results p0.005. The fact that blood nesfatin levels are significantly lower and apelin and chemerin levels are significantly higher in PCOS patients suggests that the synthesis and secretion of these adipokines are effective in the mechanism of the disease. The development of MS. Comprehensive prospective studies are needed to clarify this situation.

 Polycystic ovary syndrome PCOS is one of the most common gynecological endocrinopathies. In the literature, many studies support the involvement of IR insulin resistance and some adipokines in the pathophysiology of PCOS. In our study, we aimed to investigate the relationships of apelin, chemerin, nesfatin, IR, and MS metabolic syndrome to help clarify the pathophysiology of PCOS. We included 120 people in our prospective cohort study. We divided these 120 cases into three equal groups: a control group of healthy participants and two case groups of participants suffering from PCOS with a BMI below 30 and above 30. We conducted this study in a tertiary hospital between January 2014 and July 2014. We investigated the study groups in terms of demographic information, biochemical values, hormonal parameters, apelin, chemerin, and nesfatin values, and the relationships between MS and IR. Apelin, chemerin, and nesfatin values were 0.2330.027 ngdl, 232.79221.87 ngdl, and 2.111.27 ngdl in the control group. These values were 0.3040.093 ngdl, 313.57379.04 ngdl, and 0.850.91 ngdl in the nonobese PCOS patient group, respectively. The same parameters were 0.3040.093 ngdl, 344.31386.23 ngdl, and 0.741.42 ngdl in the obese PCOS patient group. The HOMA-IR values of the groups were 1.79  0.68, 3.61  5.45, and 4.58  4.39, respectively. The distribution of cases diagnosed with MS within the groups was 0, 10, and 17.5, respectively. We compared all these statistically significant results p0.005. The fact that blood nesfatin levels are significantly lower and apelin and chemerin levels are significantly higher in PCOS patients suggests that the synthesis and secretion of these adipokines are effective in the mechanism of the disease. The development of MS. Comprehensive prospective studies are needed to clarify this situation.

 Polycystic ovary syndrome PCOS is one of the most common gynecological endocrinopathies. In the literature, many studies support the involvement of IR insulin resistance and some adipokines in the pathophysiology of PCOS. In our study, we aimed to investigate the relationships of apelin, chemerin, nesfatin, IR, and MS metabolic syndrome to help clarify the pathophysiology of PCOS. We included 120 people in our prospective cohort study. We divided these 120 cases into three equal groups: a control group of healthy participants and two case groups of participants suffering from PCOS with a BMI below 30 and above 30. We conducted this study in a tertiary hospital between January 2014 and July 2014. We investigated the study groups in terms of demographic information, biochemical values, hormonal parameters, apelin, chemerin, and nesfatin values, and the relationships between MS and IR. Apelin, chemerin, and nesfatin values were 0.2330.027 ngdl, 232.79221.87 ngdl, and 2.111.27 ngdl in the control group. These values were 0.3040.093 ngdl, 313.57379.04 ngdl, and 0.850.91 ngdl in the nonobese PCOS patient group, respectively. The same parameters were 0.3040.093 ngdl, 344.31386.23 ngdl, and 0.741.42 ngdl in the obese PCOS patient group. The HOMA-IR values of the groups were 1.79  0.68, 3.61  5.45, and 4.58  4.39, respectively. The distribution of cases diagnosed with MS within the groups was 0, 10, and 17.5, respectively. We compared all these statistically significant results p0.005. The fact that blood nesfatin levels are significantly lower and apelin and chemerin levels are significantly higher in PCOS patients suggests that the synthesis and secretion of these adipokines are effective in the mechanism of the disease. The development of MS. Comprehensive prospective studies are needed to clarify this situation.

Makale detayları

Investigation of relationship between nesfatin's, chemerin's, apelin's levels and insulin resistance and metabolic syndrome in Polycystic Ovary Syndrome patients

Yazarlar:

Ömer Ünal | Ozan Karadeniz | Zehra Kurdoglu

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Health Care Administration

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 2, pp.284-289

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293721

pISSN:

1309-4483

apelin

chemerin

HOMA-IR

metabolic syndrome

nesfatin

polycystic ovary syndromeapelin

chemerin

HOMA-IR

metabolic syndrome

nesfatin

polycystic ovary syndrome

Sayı

Makale detayları

Yazarlar: Ömer Ünal | Ozan Karadeniz | Zehra Kurdoglu

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Health Care Administration

Dergi: Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 2, pp.284-289

Belge Tipi: Makale

Yayın Tarihi: 7/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293721

pISSN: 1309-4483

Sayı

Yazarlar:

Ömer Ünal | Ozan Karadeniz | Zehra Kurdoglu

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Health Care Administration

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 2, pp.284-289

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293721

pISSN:

1309-4483