Clinical Features of Patients with Autoantibody Positive Hashimoto Thyroiditis: A Single- Center Study

Özge Baş Aksu

Makale detayları

Clinical Features of Patients with Autoantibody Positive Hashimoto Thyroiditis: A Single- Center Study

Yazarlar:

Özge Baş Aksu

Yayıncı:

Ankara University

Ana Başlıklar:

Endocrinology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.77 Issue 2, pp.149-155

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001349758

pISSN:

0365-8104

Anahtar kelimeler:

Özet:

 Objectives: Hashimotos thyroiditis is an autoimmune condition in which thyroid cells are damaged by immunological pathways that are both cellular and antibody-mediated. Materials and Methods: The study analyzed data from 192 patients who tested positive for at least one of the anti-thyroid peroxidase anti-TPO and anti-thyroglobulin anti-Tg values and underwent thyroid ultrasonography during follow-up in an endocrinology outpatient clinic between June 2019 and 2023. The assessment included demographic information, levothyroxine L-T4 doses, autoimmune diseases and markers, thyroid volume, and nodules Results: The study population was 87.5 female, mean age 48.9813.45 years and mean follow-up 7.704.53 years. The dose of L-T4 administered median value was 50 mcgday minimum: 0, maximum: 225. Only 5.2 of patients achieved optimal vitamin D levels 30 ngmL, while 42.3 had severe vitamin D deficiency 10 ngmL. Additionally, 43.4 were found to have vitamin B12 deficiency. Thyroid ultrasonography revealed heterogeneous thyroid parenchyma in 93.2 of patients and at least one thyroid nodule in 34. The rate of isolated anti-TPO positivity was 26.6, while the rate of isolated anti-Tg positivity was 6.3, and both autoantibodies were positive in 67.2 of patients. We observed a significant correlation between L-T4 doses and anti-TPO levels r0.294, p0.001 as well as thyroid volumes r-0.239, p0.001, but not with anti-Tg levels r-0.005, p0.945. Type 1 diabetes mellitus, rheumatoid arthritis, and Addisons disease were the most common comorbid autoimmune diseases. The most commonly co-occurring autoimmune markers were anti-nuclear antibodies 40.6 and tissue transglutaminase IgA 27.3. Conclusion: Based on the data we obtained, we believe that increasing our awareness of other potential issues that may accompany this patient population in our clinical practice will help us understand how to manage these issues.

 Objectives: Hashimotos thyroiditis is an autoimmune condition in which thyroid cells are damaged by immunological pathways that are both cellular and antibody-mediated. Materials and Methods: The study analyzed data from 192 patients who tested positive for at least one of the anti-thyroid peroxidase anti-TPO and anti-thyroglobulin anti-Tg values and underwent thyroid ultrasonography during follow-up in an endocrinology outpatient clinic between June 2019 and 2023. The assessment included demographic information, levothyroxine L-T4 doses, autoimmune diseases and markers, thyroid volume, and nodules Results: The study population was 87.5 female, mean age 48.9813.45 years and mean follow-up 7.704.53 years. The dose of L-T4 administered median value was 50 mcgday minimum: 0, maximum: 225. Only 5.2 of patients achieved optimal vitamin D levels 30 ngmL, while 42.3 had severe vitamin D deficiency 10 ngmL. Additionally, 43.4 were found to have vitamin B12 deficiency. Thyroid ultrasonography revealed heterogeneous thyroid parenchyma in 93.2 of patients and at least one thyroid nodule in 34. The rate of isolated anti-TPO positivity was 26.6, while the rate of isolated anti-Tg positivity was 6.3, and both autoantibodies were positive in 67.2 of patients. We observed a significant correlation between L-T4 doses and anti-TPO levels r0.294, p0.001 as well as thyroid volumes r-0.239, p0.001, but not with anti-Tg levels r-0.005, p0.945. Type 1 diabetes mellitus, rheumatoid arthritis, and Addisons disease were the most common comorbid autoimmune diseases. The most commonly co-occurring autoimmune markers were anti-nuclear antibodies 40.6 and tissue transglutaminase IgA 27.3. Conclusion: Based on the data we obtained, we believe that increasing our awareness of other potential issues that may accompany this patient population in our clinical practice will help us understand how to manage these issues.

 Objectives: Hashimotos thyroiditis is an autoimmune condition in which thyroid cells are damaged by immunological pathways that are both cellular and antibody-mediated. Materials and Methods: The study analyzed data from 192 patients who tested positive for at least one of the anti-thyroid peroxidase anti-TPO and anti-thyroglobulin anti-Tg values and underwent thyroid ultrasonography during follow-up in an endocrinology outpatient clinic between June 2019 and 2023. The assessment included demographic information, levothyroxine L-T4 doses, autoimmune diseases and markers, thyroid volume, and nodules Results: The study population was 87.5 female, mean age 48.9813.45 years and mean follow-up 7.704.53 years. The dose of L-T4 administered median value was 50 mcgday minimum: 0, maximum: 225. Only 5.2 of patients achieved optimal vitamin D levels 30 ngmL, while 42.3 had severe vitamin D deficiency 10 ngmL. Additionally, 43.4 were found to have vitamin B12 deficiency. Thyroid ultrasonography revealed heterogeneous thyroid parenchyma in 93.2 of patients and at least one thyroid nodule in 34. The rate of isolated anti-TPO positivity was 26.6, while the rate of isolated anti-Tg positivity was 6.3, and both autoantibodies were positive in 67.2 of patients. We observed a significant correlation between L-T4 doses and anti-TPO levels r0.294, p0.001 as well as thyroid volumes r-0.239, p0.001, but not with anti-Tg levels r-0.005, p0.945. Type 1 diabetes mellitus, rheumatoid arthritis, and Addisons disease were the most common comorbid autoimmune diseases. The most commonly co-occurring autoimmune markers were anti-nuclear antibodies 40.6 and tissue transglutaminase IgA 27.3. Conclusion: Based on the data we obtained, we believe that increasing our awareness of other potential issues that may accompany this patient population in our clinical practice will help us understand how to manage these issues.

 Objectives: Hashimotos thyroiditis is an autoimmune condition in which thyroid cells are damaged by immunological pathways that are both cellular and antibody-mediated. Materials and Methods: The study analyzed data from 192 patients who tested positive for at least one of the anti-thyroid peroxidase anti-TPO and anti-thyroglobulin anti-Tg values and underwent thyroid ultrasonography during follow-up in an endocrinology outpatient clinic between June 2019 and 2023. The assessment included demographic information, levothyroxine L-T4 doses, autoimmune diseases and markers, thyroid volume, and nodules Results: The study population was 87.5 female, mean age 48.9813.45 years and mean follow-up 7.704.53 years. The dose of L-T4 administered median value was 50 mcgday minimum: 0, maximum: 225. Only 5.2 of patients achieved optimal vitamin D levels 30 ngmL, while 42.3 had severe vitamin D deficiency 10 ngmL. Additionally, 43.4 were found to have vitamin B12 deficiency. Thyroid ultrasonography revealed heterogeneous thyroid parenchyma in 93.2 of patients and at least one thyroid nodule in 34. The rate of isolated anti-TPO positivity was 26.6, while the rate of isolated anti-Tg positivity was 6.3, and both autoantibodies were positive in 67.2 of patients. We observed a significant correlation between L-T4 doses and anti-TPO levels r0.294, p0.001 as well as thyroid volumes r-0.239, p0.001, but not with anti-Tg levels r-0.005, p0.945. Type 1 diabetes mellitus, rheumatoid arthritis, and Addisons disease were the most common comorbid autoimmune diseases. The most commonly co-occurring autoimmune markers were anti-nuclear antibodies 40.6 and tissue transglutaminase IgA 27.3. Conclusion: Based on the data we obtained, we believe that increasing our awareness of other potential issues that may accompany this patient population in our clinical practice will help us understand how to manage these issues.

Makale detayları

Clinical Features of Patients with Autoantibody Positive Hashimoto Thyroiditis: A Single- Center Study

Yazarlar:

Özge Baş Aksu

Yayıncı:

Ankara University

Ana Başlıklar:

Endocrinology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.77 Issue 2, pp.149-155

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001349758

pISSN:

0365-8104

Hashimoto’s thyroiditis

autoimmunity

thyroid antibodies

Sayı

Makale detayları

Clinical Features of Patients with Autoantibody Positive Hashimoto Thyroiditis: A Single- Center Study

Yazarlar: Özge Baş Aksu

Yayıncı: Ankara University

Ana Başlıklar: Endocrinology

Dergi: Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.77 Issue 2, pp.149-155

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001349758

pISSN: 0365-8104

Hashimoto’s thyroiditis

autoimmunity

thyroid antibodies

Sayı

Yazarlar:

Özge Baş Aksu

Yayıncı:

Ankara University

Ana Başlıklar:

Endocrinology

Dergi:

Ankara Üniversitesi Tıp Fakültesi Mecmuası Vol.77 Issue 2, pp.149-155

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001349758

pISSN:

0365-8104