KADMİYUM TOKSİSİTESİ OLUŞTURULAN SIÇANLARDA TANNİK ASİTİN, AĞIR METAL GİDERİMİ VE BAZI BİYOKİMYASAL DEĞERLER ÜZERİNE ETKİSİNİN ARAŞTIRILMASI

Didem Turgut COŞAN; Aylin DAL; Ahu SOYOCAK; Ertuğrul ÇOLAK; Arzu ÇİÇEK; Hülyam KURT

Makale detayları

KADMİYUM TOKSİSİTESİ OLUŞTURULAN SIÇANLARDA TANNİK ASİTİN, AĞIR METAL GİDERİMİ VE BAZI BİYOKİMYASAL DEĞERLER ÜZERİNE ETKİSİNİN ARAŞTIRILMASI

Yazarlar:

Didem Turgut COŞAN | Aylin DAL | Ahu SOYOCAK | Ertuğrul ÇOLAK | Arzu ÇİÇEK | Hülyam KURT

Yayıncı:

Afyonkarahisar Sağlık Bilimleri Üniversitesi

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Kocatepe Medical Journal 2017 Vol.18 Issue 4, pp.146-153

Belge Tipi:

Makale

Yayın Tarihi:

10/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000532624

Sıklık:

Aylık

eISSN:

2149-7869

Özet:

 


OBJECTIVE: Cadmium (Cd), one of the major environmental
pollutants used intensively in the industrial field and could causes
a variety of vital threats due to our exposure in our daily
lives. Having a long half-life, Cd causes direct or indirect toxicity
to respiratory, urinary, cardiovascular, gastrointestinal, nervous
system and bones. It is known that Cd that accumulates in the
body causes many diseases such as osteoporosis, anemia, eosinophilia,
anosmia and chronic rhinitis. In our study, we aimed
to investigate the role of tannic acid (TA), an antioxidant substance
with a high content of flavonoids and heavy metal chelating
agents, in order to investigate its role in protecting from
Cd toxicity.


MATERIALS AND METHODS: In this study, it was used 28
Spraque-Dawley, 200-300 gr, 3-4 monthly male rats. For pre-treatment,
TA (50 mg/kg/day) was administered by intraperitoneal
(i.p) injection to the experimental groups for 5 days. And then
a single dose CdCl2 (35 mg/kg) was was administered by intragastric
(i.g).


RESULTS: It was observed that superoxide dismutase (SOD)
values decreased in hemolysate, liver and kidney by CdCl2 administration;
but increased with TA. Malondialdehyde (MDA)
values increased with CdCl2 administration whereas decreased
with TA the hemolysate and liver. TA was found to be effective
in decreasing heart accumulation, while TA was not effective
in reducing accumulation with CdCl2 administration in liver,
kidney, lung, testis and spleen. TA is not effective in reducing
increased iron accumulation with CdCl2 administration in the
kidney, spleen and heart, but in liver, lung and testis it could
be effective.


CONCLUSIONS: Food and drinks used in the daily diet may
increase the quality of life of individuals by early prevention of
certain diseases that may result in exposure to toxic agents. In
our study, it has been shown that TA, which is consumed in our
daily lives, may be effective in protecting substances from heavy
metal toxicity. According to the results obtained, different
results could be reached in different tissues; but when assessed
in general, the harmful effects of Cd, or at least the result that
TA have been achieved to reduce the accumulation of some tissues.

.

Makale detayları

KADMİYUM TOKSİSİTESİ OLUŞTURULAN SIÇANLARDA TANNİK ASİTİN, AĞIR METAL GİDERİMİ VE BAZI BİYOKİMYASAL DEĞERLER ÜZERİNE ETKİSİNİN ARAŞTIRILMASI

Yazarlar: Didem Turgut COŞAN | Aylin DAL | Ahu SOYOCAK | Ertuğrul ÇOLAK | Arzu ÇİÇEK | Hülyam KURT

Yayıncı: Afyonkarahisar Sağlık Bilimleri Üniversitesi

Ana Başlıklar: Sağlık teşvikleri

Dergi: Kocatepe Medical Journal 2017 Vol.18 Issue 4, pp.146-153

Belge Tipi: Makale

Yayın Tarihi: 10/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000532624

Sıklık: Aylık

eISSN: 2149-7869

Sayı

Yazarlar:

Didem Turgut COŞAN | Aylin DAL | Ahu SOYOCAK | Ertuğrul ÇOLAK | Arzu ÇİÇEK | Hülyam KURT

Yayıncı:

Afyonkarahisar Sağlık Bilimleri Üniversitesi

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Kocatepe Medical Journal 2017 Vol.18 Issue 4, pp.146-153

Belge Tipi:

Makale

Yayın Tarihi:

10/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000532624

Sıklık:

Aylık

eISSN:

2149-7869