The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute  graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic  stem cell transplantation

Seyed Ahmad HOSEİNİAN; Davood JAFARİ; Mehdi MAHMOODİ; Kamran ALİMOGHADDAM; Mohammadreza OSTADALİ; Azita Talebzadeh BONAKDAR; Arron Munggela FOMA; Mir Saeed YEKANİNEJAD; Ali Akbar AMİRZARGAR

Makale detayları

The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation

Yazarlar:

Seyed Ahmad HOSEİNİAN | Davood JAFARİ | Mehdi MAHMOODİ | Kamran ALİMOGHADDAM | Mohammadreza OSTADALİ | Azita Talebzadeh BONAKDAR | Arron Munggela FOMA | Mir Saeed YEKANİNEJAD | Ali Akbar AMİRZARGAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.794-804

Belge Tipi:

Makale

Yayın Tarihi:

7/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750641

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: After allogeneic hematopoietic stem cell transplantation (allo-HSCT), donor natural killer (NK) cells trigger  alloreactions against potential recipient cells by their killer immunoglobulin-like receptors (KIRs). This study investigated whether  KIR/HLA genotypes and KIR haplotypes of donors and recipients exhibit a critical function in the prevalence of acute graft-versus-host  disease (aGVHD) and persistence of the graft after HLA-identical sibling allo-HSCT for patients with hematological malignancies.  Materials and methods: We studied KIR and HLA genotypes in 115 related donors and recipients (56 patients with AML and 59  patients with ALL) who had received allo-HSCT from HLA-matched sibling donors. We evaluated 17 KIR genes and some alleles,  including their ligands, using the PCR-SSP assay.  Results: KIR gene frequency results between donors and recipients showed that donors had more activating KIR than their recipients.  Chi-square comparison of KIR genotype frequencies in donors versus recipients revealed a significant difference (P < 0.001). We found  a survival association between the donor lacking and the recipient having group B KIR haplotypes, although this was not statistically  significant.  Conclusion: This study suggests that we could exploit NK cell alloreactivity as a part of the optimization of donor selection and potential  immunotherapeutic regimens to help facilitate good engraftment and reduce the risk of aGVHD incidence after allo-HSCT.

Makale detayları

The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation

Yazarlar: Seyed Ahmad HOSEİNİAN | Davood JAFARİ | Mehdi MAHMOODİ | Kamran ALİMOGHADDAM | Mohammadreza OSTADALİ | Azita Talebzadeh BONAKDAR | Arron Munggela FOMA | Mir Saeed YEKANİNEJAD | Ali Akbar AMİRZARGAR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.794-804

Belge Tipi: Makale

Yayın Tarihi: 7/2018

Belge Dili: Türkçe

Document ID (Org No.): 2000750641

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Seyed Ahmad HOSEİNİAN | Davood JAFARİ | Mehdi MAHMOODİ | Kamran ALİMOGHADDAM | Mohammadreza OSTADALİ | Azita Talebzadeh BONAKDAR | Arron Munggela FOMA | Mir Saeed YEKANİNEJAD | Ali Akbar AMİRZARGAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 4, pp.794-804

Belge Tipi:

Makale

Yayın Tarihi:

7/2018

Belge Dili:

Türkçe

Document ID (Org No.):

2000750641

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144