Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation

Jürgen KRAUSS; Doris UNTERREITMEIER; Franz BRACHER

Makale detayları

Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation

Yazarlar:

Jürgen KRAUSS | Doris UNTERREITMEIER | Franz BRACHER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2006 Vol.30 Issue 4, pp.451-454

Belge Tipi:

Makale

Yayın Tarihi:

3/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000728860

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

The thiophene analogue of (\pm)-4-ipomeanol (1) was  prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol.   The key steps were a Sonogashira reaction, followed by HgO catalysed  hydratisation of the triple bond.  The resulting thiophene was tested  in the MTT assay for its cytotoxic activity against HL 60 cells.

 

The thiophene analogue of (\pm)-4-ipomeanol (1) was  prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol.   The key steps were a Sonogashira reaction, followed by HgO catalysed  hydratisation of the triple bond.  The resulting thiophene was tested  in the MTT assay for its cytotoxic activity against HL 60 cells.

Makale detayları

Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation

Yazarlar: Jürgen KRAUSS | Doris UNTERREITMEIER | Franz BRACHER

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2006 Vol.30 Issue 4, pp.451-454

Belge Tipi: Makale

Yayın Tarihi: 3/2006

Belge Dili: Türkçe

Document ID (Org No.): 2000728860

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Jürgen KRAUSS | Doris UNTERREITMEIER | Franz BRACHER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2006 Vol.30 Issue 4, pp.451-454

Belge Tipi:

Makale

Yayın Tarihi:

3/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000728860

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527