The role of diffusion-weighted imaging in the diagnosis of early kidney damage

Şeyhmus Kavak

Makale detayları

The role of diffusion-weighted imaging in the diagnosis of early kidney damage

Yazarlar:

Şeyhmus Kavak

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Radiology and Organ Imaging

Dergi:

The European Research Journal Vol.9 Issue 2, pp.328-337

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001283006

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objective: This study aimed to determine a threshold value for distinguishing early-stage chronic kidney disease CKD from moderate and advanced stages as well as patients with early-stage CKD from those with normal renal function using apparent diffusion coefficient ADC and normalized ADC values. Methods: This retrospective study enrolled 257 patients. Diffusion-weighted images were obtained with a set of b  50,400,800 values. In each patient, six ADC values were measured from upper, middle, and lower areas of both kidneys, and three ADC values were measured from the spleen. Patients with CKD were classified into five subgroups and healthy patients were classified into two subgroups according to their glomerular filtration rate GFR. Results: The renal ADC values were found to be positively correlated with GFR r  0.790, p  0.001 and negatively correlated with creatinine levels r  0.709, p  0.001. The mean ADC values of the stage 1 and 2 CKD groups were found to be significantly higher than those of advanced-stage CKD groups  p  0.001, and these values were significantly lower in the stage 1 and 2 CKD groups than in the healthy group  p  0.001. With a cut-off value of 1.791 for ADC, the sensitivity was 76.5 and the specificity was 85 while distinguishing between patients with early- and advanced-stage CKD. Conclusion: Renal and normalized ADC values are strongly correlated with CKD stages, and with the use of appropriate threshold values, the difference between early and advanced stages of CKD can be predicted.

 Objective: This study aimed to determine a threshold value for distinguishing early-stage chronic kidney disease CKD from moderate and advanced stages as well as patients with early-stage CKD from those with normal renal function using apparent diffusion coefficient ADC and normalized ADC values. Methods: This retrospective study enrolled 257 patients. Diffusion-weighted images were obtained with a set of b  50,400,800 values. In each patient, six ADC values were measured from upper, middle, and lower areas of both kidneys, and three ADC values were measured from the spleen. Patients with CKD were classified into five subgroups and healthy patients were classified into two subgroups according to their glomerular filtration rate GFR. Results: The renal ADC values were found to be positively correlated with GFR r  0.790, p  0.001 and negatively correlated with creatinine levels r  0.709, p  0.001. The mean ADC values of the stage 1 and 2 CKD groups were found to be significantly higher than those of advanced-stage CKD groups  p  0.001, and these values were significantly lower in the stage 1 and 2 CKD groups than in the healthy group  p  0.001. With a cut-off value of 1.791 for ADC, the sensitivity was 76.5 and the specificity was 85 while distinguishing between patients with early- and advanced-stage CKD. Conclusion: Renal and normalized ADC values are strongly correlated with CKD stages, and with the use of appropriate threshold values, the difference between early and advanced stages of CKD can be predicted.

 Objective: This study aimed to determine a threshold value for distinguishing early-stage chronic kidney disease CKD from moderate and advanced stages as well as patients with early-stage CKD from those with normal renal function using apparent diffusion coefficient ADC and normalized ADC values. Methods: This retrospective study enrolled 257 patients. Diffusion-weighted images were obtained with a set of b  50,400,800 values. In each patient, six ADC values were measured from upper, middle, and lower areas of both kidneys, and three ADC values were measured from the spleen. Patients with CKD were classified into five subgroups and healthy patients were classified into two subgroups according to their glomerular filtration rate GFR. Results: The renal ADC values were found to be positively correlated with GFR r  0.790, p  0.001 and negatively correlated with creatinine levels r  0.709, p  0.001. The mean ADC values of the stage 1 and 2 CKD groups were found to be significantly higher than those of advanced-stage CKD groups  p  0.001, and these values were significantly lower in the stage 1 and 2 CKD groups than in the healthy group  p  0.001. With a cut-off value of 1.791 for ADC, the sensitivity was 76.5 and the specificity was 85 while distinguishing between patients with early- and advanced-stage CKD. Conclusion: Renal and normalized ADC values are strongly correlated with CKD stages, and with the use of appropriate threshold values, the difference between early and advanced stages of CKD can be predicted.

 Objective: This study aimed to determine a threshold value for distinguishing early-stage chronic kidney disease CKD from moderate and advanced stages as well as patients with early-stage CKD from those with normal renal function using apparent diffusion coefficient ADC and normalized ADC values. Methods: This retrospective study enrolled 257 patients. Diffusion-weighted images were obtained with a set of b  50,400,800 values. In each patient, six ADC values were measured from upper, middle, and lower areas of both kidneys, and three ADC values were measured from the spleen. Patients with CKD were classified into five subgroups and healthy patients were classified into two subgroups according to their glomerular filtration rate GFR. Results: The renal ADC values were found to be positively correlated with GFR r  0.790, p  0.001 and negatively correlated with creatinine levels r  0.709, p  0.001. The mean ADC values of the stage 1 and 2 CKD groups were found to be significantly higher than those of advanced-stage CKD groups  p  0.001, and these values were significantly lower in the stage 1 and 2 CKD groups than in the healthy group  p  0.001. With a cut-off value of 1.791 for ADC, the sensitivity was 76.5 and the specificity was 85 while distinguishing between patients with early- and advanced-stage CKD. Conclusion: Renal and normalized ADC values are strongly correlated with CKD stages, and with the use of appropriate threshold values, the difference between early and advanced stages of CKD can be predicted.

Makale detayları

The role of diffusion-weighted imaging in the diagnosis of early kidney damage

Yazarlar:

Şeyhmus Kavak

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Radiology and Organ Imaging

Dergi:

The European Research Journal Vol.9 Issue 2, pp.328-337

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001283006

pISSN:

2149-3189

Diffusion-weighted imaging

apparent diffusion coefficient

chronic kidney disease

Sayı

Makale detayları

The role of diffusion-weighted imaging in the diagnosis of early kidney damage

Yazarlar: Şeyhmus Kavak

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Radiology and Organ Imaging

Dergi: The European Research Journal Vol.9 Issue 2, pp.328-337

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001283006

pISSN: 2149-3189

Diffusion-weighted imaging

apparent diffusion coefficient

chronic kidney disease

Sayı

Yazarlar:

Şeyhmus Kavak

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Radiology and Organ Imaging

Dergi:

The European Research Journal Vol.9 Issue 2, pp.328-337

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001283006

pISSN:

2149-3189