Topical anti-inflammatory and analgesic activities of Laportea decumana (Roxb) Wedd extract cream in rats

N.A.

Makale detayları

Topical anti-inflammatory and analgesic activities of Laportea decumana (Roxb) Wedd extract cream in rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.2026-2034

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346791

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Laportea decumana is a plant that has traditionally been used to treat pain. This study aimed to determine the anti-inflammatory and analgesic activity of L. decumana leaf extract LD extract topical cream in rats. The anti-inflammatory effects of LD cream at a concentration of 0.5, 1, and 2 extract were determined by carrageen-induced acute inflammation on rat hind paws. Hydrocortisone 1 cream was used as a comparison. The volume of oedema and IL-6 level were analysed following one day of application. Another set of experiments was performed to assess the analgesic activity of LD cream by intraplantar injection of 1 formalin, using 30 methyl salicylate cream as a comparison. Pain indicators, including foot stamping and licking, were observed for 60 minutes. The results showed that rats received the 2 LD cream had reduced carrageenan-induced paw oedema of up to 13.1 at the 3rd hour, and 8.1 at the 4th hour, compared to the placebo p  0.05. Rats treated with the 2 LD cream also had the lowest level of IL-6 in their paw tissue, which was comparable to 1 hydrocortisone cream treatment. Similarly, in the analgesic tests, a significant decrease in the amount of foot stamping and licking was seen following the administration of 2 LD cream p  0.05. This analgesic effect was similar to that of 30 methyl salicylate cream. In conclusion, cream containing 2 LD extract provided anti-inflammatory and analgesic effects in rats, and might be useful for treating pain and inflammation in humans.

 Laportea decumana is a plant that has traditionally been used to treat pain. This study aimed to determine the anti-inflammatory and analgesic activity of L. decumana leaf extract LD extract topical cream in rats. The anti-inflammatory effects of LD cream at a concentration of 0.5, 1, and 2 extract were determined by carrageen-induced acute inflammation on rat hind paws. Hydrocortisone 1 cream was used as a comparison. The volume of oedema and IL-6 level were analysed following one day of application. Another set of experiments was performed to assess the analgesic activity of LD cream by intraplantar injection of 1 formalin, using 30 methyl salicylate cream as a comparison. Pain indicators, including foot stamping and licking, were observed for 60 minutes. The results showed that rats received the 2 LD cream had reduced carrageenan-induced paw oedema of up to 13.1 at the 3rd hour, and 8.1 at the 4th hour, compared to the placebo p  0.05. Rats treated with the 2 LD cream also had the lowest level of IL-6 in their paw tissue, which was comparable to 1 hydrocortisone cream treatment. Similarly, in the analgesic tests, a significant decrease in the amount of foot stamping and licking was seen following the administration of 2 LD cream p  0.05. This analgesic effect was similar to that of 30 methyl salicylate cream. In conclusion, cream containing 2 LD extract provided anti-inflammatory and analgesic effects in rats, and might be useful for treating pain and inflammation in humans.

 Laportea decumana is a plant that has traditionally been used to treat pain. This study aimed to determine the anti-inflammatory and analgesic activity of L. decumana leaf extract LD extract topical cream in rats. The anti-inflammatory effects of LD cream at a concentration of 0.5, 1, and 2 extract were determined by carrageen-induced acute inflammation on rat hind paws. Hydrocortisone 1 cream was used as a comparison. The volume of oedema and IL-6 level were analysed following one day of application. Another set of experiments was performed to assess the analgesic activity of LD cream by intraplantar injection of 1 formalin, using 30 methyl salicylate cream as a comparison. Pain indicators, including foot stamping and licking, were observed for 60 minutes. The results showed that rats received the 2 LD cream had reduced carrageenan-induced paw oedema of up to 13.1 at the 3rd hour, and 8.1 at the 4th hour, compared to the placebo p  0.05. Rats treated with the 2 LD cream also had the lowest level of IL-6 in their paw tissue, which was comparable to 1 hydrocortisone cream treatment. Similarly, in the analgesic tests, a significant decrease in the amount of foot stamping and licking was seen following the administration of 2 LD cream p  0.05. This analgesic effect was similar to that of 30 methyl salicylate cream. In conclusion, cream containing 2 LD extract provided anti-inflammatory and analgesic effects in rats, and might be useful for treating pain and inflammation in humans.

 Laportea decumana is a plant that has traditionally been used to treat pain. This study aimed to determine the anti-inflammatory and analgesic activity of L. decumana leaf extract LD extract topical cream in rats. The anti-inflammatory effects of LD cream at a concentration of 0.5, 1, and 2 extract were determined by carrageen-induced acute inflammation on rat hind paws. Hydrocortisone 1 cream was used as a comparison. The volume of oedema and IL-6 level were analysed following one day of application. Another set of experiments was performed to assess the analgesic activity of LD cream by intraplantar injection of 1 formalin, using 30 methyl salicylate cream as a comparison. Pain indicators, including foot stamping and licking, were observed for 60 minutes. The results showed that rats received the 2 LD cream had reduced carrageenan-induced paw oedema of up to 13.1 at the 3rd hour, and 8.1 at the 4th hour, compared to the placebo p  0.05. Rats treated with the 2 LD cream also had the lowest level of IL-6 in their paw tissue, which was comparable to 1 hydrocortisone cream treatment. Similarly, in the analgesic tests, a significant decrease in the amount of foot stamping and licking was seen following the administration of 2 LD cream p  0.05. This analgesic effect was similar to that of 30 methyl salicylate cream. In conclusion, cream containing 2 LD extract provided anti-inflammatory and analgesic effects in rats, and might be useful for treating pain and inflammation in humans.

Makale detayları

Topical anti-inflammatory and analgesic activities of Laportea decumana (Roxb) Wedd extract cream in rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.2026-2034

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346791

pISSN:

2630-6344

Laportea decumana

anti-inflammatory

Carrageenan

analgesic

formalin

Sayı

Makale detayları

Topical anti-inflammatory and analgesic activities of Laportea decumana (Roxb) Wedd extract cream in rats

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 5, pp.2026-2034

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346791

pISSN: 2630-6344

Laportea decumana

anti-inflammatory

Carrageenan

analgesic

formalin

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 5, pp.2026-2034

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346791

pISSN:

2630-6344