Examination of the possible effects of ozone application in Duchenne muscular dystrophy

N.A.

Makale detayları

Examination of the possible effects of ozone application in Duchenne muscular dystrophy

Yazarlar:

N.A.

Yayıncı:

Ataturk University

Ana Başlıklar:

Systems Biology

Dergi:

Journal of Basic Health Vol.3 Issue 1, pp.8-13

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314701

pISSN:

2980-2504

Anahtar kelimeler:

Özet:

 Duchenne muscular dystrophy DMD, an X-linked disorder, has an incidence of one in 5000 boys and presents in early childhood with proximal muscle weakness. The disease is caused by mutations in DMD encoding dystrophin that abolish the production of dystrophin in muscle. In this study, we aimed to investigate the effect of ozone therapy OT on muscle oxygenation in DMD patients. For this purpose, DMD was developed in the primary skeletal muscle cell line. The changes that occurred by administering OT to the cell lines were observed. OT reduced mitochondrial ROS caused by DMD, partially improved the shape changes in myoblasts, but had no effect on dystrophin. OT to DMD patients may have a positive effect on muscle cells.

 Duchenne muscular dystrophy DMD, an X-linked disorder, has an incidence of one in 5000 boys and presents in early childhood with proximal muscle weakness. The disease is caused by mutations in DMD encoding dystrophin that abolish the production of dystrophin in muscle. In this study, we aimed to investigate the effect of ozone therapy OT on muscle oxygenation in DMD patients. For this purpose, DMD was developed in the primary skeletal muscle cell line. The changes that occurred by administering OT to the cell lines were observed. OT reduced mitochondrial ROS caused by DMD, partially improved the shape changes in myoblasts, but had no effect on dystrophin. OT to DMD patients may have a positive effect on muscle cells.

 Duchenne muscular dystrophy DMD, an X-linked disorder, has an incidence of one in 5000 boys and presents in early childhood with proximal muscle weakness. The disease is caused by mutations in DMD encoding dystrophin that abolish the production of dystrophin in muscle. In this study, we aimed to investigate the effect of ozone therapy OT on muscle oxygenation in DMD patients. For this purpose, DMD was developed in the primary skeletal muscle cell line. The changes that occurred by administering OT to the cell lines were observed. OT reduced mitochondrial ROS caused by DMD, partially improved the shape changes in myoblasts, but had no effect on dystrophin. OT to DMD patients may have a positive effect on muscle cells.

 Duchenne muscular dystrophy DMD, an X-linked disorder, has an incidence of one in 5000 boys and presents in early childhood with proximal muscle weakness. The disease is caused by mutations in DMD encoding dystrophin that abolish the production of dystrophin in muscle. In this study, we aimed to investigate the effect of ozone therapy OT on muscle oxygenation in DMD patients. For this purpose, DMD was developed in the primary skeletal muscle cell line. The changes that occurred by administering OT to the cell lines were observed. OT reduced mitochondrial ROS caused by DMD, partially improved the shape changes in myoblasts, but had no effect on dystrophin. OT to DMD patients may have a positive effect on muscle cells.

Makale detayları

Examination of the possible effects of ozone application in Duchenne muscular dystrophy

Yazarlar: N.A.

Yayıncı: Ataturk University

Ana Başlıklar: Systems Biology

Dergi: Journal of Basic Health Vol.3 Issue 1, pp.8-13

Belge Tipi: Makale

Yayın Tarihi: 3/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001314701

pISSN: 2980-2504

Duchenne muscular dystrophy

mitochondrial ROS

ozone therapy

Sayı

Yazarlar:

N.A.

Yayıncı:

Ataturk University

Ana Başlıklar:

Systems Biology

Dergi:

Journal of Basic Health Vol.3 Issue 1, pp.8-13

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001314701

pISSN:

2980-2504