Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold

Aysel Koc DEMİR

doi:https://doi.org/10.17350/HJSE19030000047

Makale detayları

Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold

Yazarlar:

Aysel Koc DEMİR

Yayıncı:

Hitit University

Dergi:

Hittite Journal of Science and Engineering 2017 Vol.4 Issue 1, pp.45-49

Belge Tipi:

Makale

Yayın Tarihi:

6/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000451827

Sıklık:

Üç Aylık

eISSN:

2148-4171

DOI:

https://doi.org/10.17350/HJSE19030000047

Özet:

 

I n this study, a scaffold composed of chitosan  C  and organoclay  OC  was prepared by utilizing freeze-drying method. The composition of resulting composite scaffold was evaluated using FTIR and SEM. The in vivo cytocompatibility of the composite was evaluated in vivo, by seeding MC3T3-E1 cells on composite scaffolds. In-vitro cell viability and proliferation were investigated using the MTT assay, while cell-scaffold constructs were evaluated using scanning electron microscopy. Preliminary in vivo experiments were also performed to evaluate tissue compatibility and ectopic boneforming potential of C/OC composite scaffolds with MC3T3-E1 cells. The findings suggest that C/OC construct supported the proliferation of MC3T3-E1 cells, presented histobiocompatibility and promoted formation of calcified matrix. Based on the results, we conclude that the characterized C/OC composite system may have potential for use in bone tissue engineering applications.

Makale detayları

Evaluation of Chitosan /Organoclay Composite as Bone Tissue Engineering Scaffold

Yazarlar: Aysel Koc DEMİR

Yayıncı: Hitit University

Dergi: Hittite Journal of Science and Engineering 2017 Vol.4 Issue 1, pp.45-49

Belge Tipi: Makale

Yayın Tarihi: 6/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000451827

Sıklık: Üç Aylık

eISSN: 2148-4171

DOI: https://doi.org/10.17350/HJSE19030000047

Sayı

Yazarlar:

Aysel Koc DEMİR

Yayıncı:

Hitit University

Dergi:

Hittite Journal of Science and Engineering 2017 Vol.4 Issue 1, pp.45-49

Belge Tipi:

Makale

Yayın Tarihi:

6/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000451827

Sıklık:

Üç Aylık

eISSN:

2148-4171

DOI:

https://doi.org/10.17350/HJSE19030000047