Evaluation of antidiabetic potential and protective effects of Acioa barteri against biochemical changes in alloxaninduced diabetic rats

N.A.

Makale detayları

Evaluation of antidiabetic potential and protective effects of Acioa barteri against biochemical changes in alloxaninduced diabetic rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 6, pp.2294-2309

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346297

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Acioa barteri is a medicinal plant commonly known as Monkey fruit that grows in the tropical rain forests in many countries in West Africa. The plant extracts are useful in traditional medicine against diverse diseases and medical conditions. This study evaluated the antidiabetic and protective effect of Acioa barteri extract EEABL against biochemical changes in alloxan-induced diabetic rats. The lethal dose of EEABL was evaluated using standard procedure. Antidiabetic and protective properties of EEABL were evaluated using sixty mature male albino rats selected into six groups containing ten rats each. Group 1 was the normal control rats without alloxan-induction but received 2mLkg of normal saline. Groups 2  6 were rats induced diabetes by the intraperitoneal administration of 150 mgkg alloxan-monohydrate dissolved in normal saline. Group 2 was the diabetic control, and group 3 was treated with 3 mgkg Glibenclamide. Groups 4, 5, and 6 were treated with 200, 400, and 800 mgkg EEABL, respectively for 28 days. The results of the acute toxicity study of EEABL showed that it has a lethal dose LD50 value above 5000 mgkg. The phytochemical study showed that EEABL contains alkaloids 96.890.42 mg100g, flavonoids 105.981.73 mgkg, and phenols 77.580.29 mgkg in high concentrations. While tannins 13.130.43 mg100g and terpenes 18.240.78 mg100g were detected in moderate concentration in EEABL, cardiac glycoside 10.390.20 mg100g, steroids 8.280.19 mg100g and saponins 6.340.19 mg100g were found to be present in low concentrations. Treatment with EEABL lowered blood glucose, urea, and creatinine significantly in the alloxan-induced diabetic rats compared to the diabetic control. Treatment with EEABL also improved haematological parameters, antioxidant vitamins B12, B6, B2, C, and E, serum electrolytes, and lipid profile in the alloxan-induced diabetic rats compared to the diabetic control. This study revealed that EEABL has antidiabetic effects and confers protection against biochemical changes in alloxan-induced diabetic rats.

 Acioa barteri is a medicinal plant commonly known as Monkey fruit that grows in the tropical rain forests in many countries in West Africa. The plant extracts are useful in traditional medicine against diverse diseases and medical conditions. This study evaluated the antidiabetic and protective effect of Acioa barteri extract EEABL against biochemical changes in alloxan-induced diabetic rats. The lethal dose of EEABL was evaluated using standard procedure. Antidiabetic and protective properties of EEABL were evaluated using sixty mature male albino rats selected into six groups containing ten rats each. Group 1 was the normal control rats without alloxan-induction but received 2mLkg of normal saline. Groups 2  6 were rats induced diabetes by the intraperitoneal administration of 150 mgkg alloxan-monohydrate dissolved in normal saline. Group 2 was the diabetic control, and group 3 was treated with 3 mgkg Glibenclamide. Groups 4, 5, and 6 were treated with 200, 400, and 800 mgkg EEABL, respectively for 28 days. The results of the acute toxicity study of EEABL showed that it has a lethal dose LD50 value above 5000 mgkg. The phytochemical study showed that EEABL contains alkaloids 96.890.42 mg100g, flavonoids 105.981.73 mgkg, and phenols 77.580.29 mgkg in high concentrations. While tannins 13.130.43 mg100g and terpenes 18.240.78 mg100g were detected in moderate concentration in EEABL, cardiac glycoside 10.390.20 mg100g, steroids 8.280.19 mg100g and saponins 6.340.19 mg100g were found to be present in low concentrations. Treatment with EEABL lowered blood glucose, urea, and creatinine significantly in the alloxan-induced diabetic rats compared to the diabetic control. Treatment with EEABL also improved haematological parameters, antioxidant vitamins B12, B6, B2, C, and E, serum electrolytes, and lipid profile in the alloxan-induced diabetic rats compared to the diabetic control. This study revealed that EEABL has antidiabetic effects and confers protection against biochemical changes in alloxan-induced diabetic rats.

 Acioa barteri is a medicinal plant commonly known as Monkey fruit that grows in the tropical rain forests in many countries in West Africa. The plant extracts are useful in traditional medicine against diverse diseases and medical conditions. This study evaluated the antidiabetic and protective effect of Acioa barteri extract EEABL against biochemical changes in alloxan-induced diabetic rats. The lethal dose of EEABL was evaluated using standard procedure. Antidiabetic and protective properties of EEABL were evaluated using sixty mature male albino rats selected into six groups containing ten rats each. Group 1 was the normal control rats without alloxan-induction but received 2mLkg of normal saline. Groups 2  6 were rats induced diabetes by the intraperitoneal administration of 150 mgkg alloxan-monohydrate dissolved in normal saline. Group 2 was the diabetic control, and group 3 was treated with 3 mgkg Glibenclamide. Groups 4, 5, and 6 were treated with 200, 400, and 800 mgkg EEABL, respectively for 28 days. The results of the acute toxicity study of EEABL showed that it has a lethal dose LD50 value above 5000 mgkg. The phytochemical study showed that EEABL contains alkaloids 96.890.42 mg100g, flavonoids 105.981.73 mgkg, and phenols 77.580.29 mgkg in high concentrations. While tannins 13.130.43 mg100g and terpenes 18.240.78 mg100g were detected in moderate concentration in EEABL, cardiac glycoside 10.390.20 mg100g, steroids 8.280.19 mg100g and saponins 6.340.19 mg100g were found to be present in low concentrations. Treatment with EEABL lowered blood glucose, urea, and creatinine significantly in the alloxan-induced diabetic rats compared to the diabetic control. Treatment with EEABL also improved haematological parameters, antioxidant vitamins B12, B6, B2, C, and E, serum electrolytes, and lipid profile in the alloxan-induced diabetic rats compared to the diabetic control. This study revealed that EEABL has antidiabetic effects and confers protection against biochemical changes in alloxan-induced diabetic rats.

 Acioa barteri is a medicinal plant commonly known as Monkey fruit that grows in the tropical rain forests in many countries in West Africa. The plant extracts are useful in traditional medicine against diverse diseases and medical conditions. This study evaluated the antidiabetic and protective effect of Acioa barteri extract EEABL against biochemical changes in alloxan-induced diabetic rats. The lethal dose of EEABL was evaluated using standard procedure. Antidiabetic and protective properties of EEABL were evaluated using sixty mature male albino rats selected into six groups containing ten rats each. Group 1 was the normal control rats without alloxan-induction but received 2mLkg of normal saline. Groups 2  6 were rats induced diabetes by the intraperitoneal administration of 150 mgkg alloxan-monohydrate dissolved in normal saline. Group 2 was the diabetic control, and group 3 was treated with 3 mgkg Glibenclamide. Groups 4, 5, and 6 were treated with 200, 400, and 800 mgkg EEABL, respectively for 28 days. The results of the acute toxicity study of EEABL showed that it has a lethal dose LD50 value above 5000 mgkg. The phytochemical study showed that EEABL contains alkaloids 96.890.42 mg100g, flavonoids 105.981.73 mgkg, and phenols 77.580.29 mgkg in high concentrations. While tannins 13.130.43 mg100g and terpenes 18.240.78 mg100g were detected in moderate concentration in EEABL, cardiac glycoside 10.390.20 mg100g, steroids 8.280.19 mg100g and saponins 6.340.19 mg100g were found to be present in low concentrations. Treatment with EEABL lowered blood glucose, urea, and creatinine significantly in the alloxan-induced diabetic rats compared to the diabetic control. Treatment with EEABL also improved haematological parameters, antioxidant vitamins B12, B6, B2, C, and E, serum electrolytes, and lipid profile in the alloxan-induced diabetic rats compared to the diabetic control. This study revealed that EEABL has antidiabetic effects and confers protection against biochemical changes in alloxan-induced diabetic rats.

Makale detayları

Evaluation of antidiabetic potential and protective effects of Acioa barteri against biochemical changes in alloxaninduced diabetic rats

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 6, pp.2294-2309

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346297

pISSN:

2630-6344

Acioa barteri

antioxidant vitamins

hyperglycaemia

lipid profile

phytochemicals

renal functions.

Sayı

Makale detayları

Evaluation of antidiabetic potential and protective effects of Acioa barteri against biochemical changes in alloxaninduced diabetic rats

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 6, pp.2294-2309

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346297

pISSN: 2630-6344

Acioa barteri

antioxidant vitamins

hyperglycaemia

lipid profile

phytochemicals

renal functions.

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 6, pp.2294-2309

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346297

pISSN:

2630-6344