The Effect of Antibiotic Use on Intensive Care Unit Admission and Mortality in Inpatients with COVID-19 Diagnosis

Taliha Karakök; Ahmet Doğan; Onur Acar

Makale detayları

The Effect of Antibiotic Use on Intensive Care Unit Admission and Mortality in Inpatients with COVID-19 Diagnosis

Yazarlar:

Taliha Karakök | Ahmet Doğan | Onur Acar

Yayıncı:

Duzce University

Ana Başlıklar:

Infectious Diseases | Clinical Microbiology

Dergi:

Duzce Medical Journal Vol.27 Issue 1, pp.17-22

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338373

pISSN:

1307-671X

Anahtar kelimeler:

Özet:

 Aim: The coronavirus disease 2019 COVID-19 pandemic had and continues to directly impact antibiotic management. This study aimed to evaluate antibiotic use and its impact on intensive care unit ICU admission and mortality in COVID-19 patients. Material and Methods: The medical records of 324 COVID-19 patients aged 18 years who had clinical signs of infection and were followed up in the service were retrospectively evaluated. Patients were divided into two groups, those who received antibiotics and those who did not. Patients transferred from the ICU to the ward, discharged on the first day, or had missing data were excluded from the study. Results: Of the patients, 172 53.1 were male, 152 46.9 were female, and 212 65.4 received antibiotic treatment. Hospitalization longer than one week p0.001, pulse steroid use p0.011, ICU admission p0.002 and mortality p0.001 were significantly higher in patients receiving antibiotics. While CRP p0.001, PCT p0.001, and ferritin p0.017 values obtained at admission and 48-72 hours were also found to be higher in antibiotic-using patients, there was no difference in CRP value p0.052 at discharge. Duration of hospitalization, antibiotic use, pulse steroid use, and being 60 years and older were found to be risk factors for mortality and ICU admission. Conclusion: Overusing antibiotics in COVID-19 patients did not have a positive effect on mortality and ICU requirements. Considering the harms of excessive antibiotic use, recommendations and practices that lead to rational antibiotic use are needed. Furthermore, factors predicting mortality and ICU can be used in clinical practice.

 Aim: The coronavirus disease 2019 COVID-19 pandemic had and continues to directly impact antibiotic management. This study aimed to evaluate antibiotic use and its impact on intensive care unit ICU admission and mortality in COVID-19 patients. Material and Methods: The medical records of 324 COVID-19 patients aged 18 years who had clinical signs of infection and were followed up in the service were retrospectively evaluated. Patients were divided into two groups, those who received antibiotics and those who did not. Patients transferred from the ICU to the ward, discharged on the first day, or had missing data were excluded from the study. Results: Of the patients, 172 53.1 were male, 152 46.9 were female, and 212 65.4 received antibiotic treatment. Hospitalization longer than one week p0.001, pulse steroid use p0.011, ICU admission p0.002 and mortality p0.001 were significantly higher in patients receiving antibiotics. While CRP p0.001, PCT p0.001, and ferritin p0.017 values obtained at admission and 48-72 hours were also found to be higher in antibiotic-using patients, there was no difference in CRP value p0.052 at discharge. Duration of hospitalization, antibiotic use, pulse steroid use, and being 60 years and older were found to be risk factors for mortality and ICU admission. Conclusion: Overusing antibiotics in COVID-19 patients did not have a positive effect on mortality and ICU requirements. Considering the harms of excessive antibiotic use, recommendations and practices that lead to rational antibiotic use are needed. Furthermore, factors predicting mortality and ICU can be used in clinical practice.

 Aim: The coronavirus disease 2019 COVID-19 pandemic had and continues to directly impact antibiotic management. This study aimed to evaluate antibiotic use and its impact on intensive care unit ICU admission and mortality in COVID-19 patients. Material and Methods: The medical records of 324 COVID-19 patients aged 18 years who had clinical signs of infection and were followed up in the service were retrospectively evaluated. Patients were divided into two groups, those who received antibiotics and those who did not. Patients transferred from the ICU to the ward, discharged on the first day, or had missing data were excluded from the study. Results: Of the patients, 172 53.1 were male, 152 46.9 were female, and 212 65.4 received antibiotic treatment. Hospitalization longer than one week p0.001, pulse steroid use p0.011, ICU admission p0.002 and mortality p0.001 were significantly higher in patients receiving antibiotics. While CRP p0.001, PCT p0.001, and ferritin p0.017 values obtained at admission and 48-72 hours were also found to be higher in antibiotic-using patients, there was no difference in CRP value p0.052 at discharge. Duration of hospitalization, antibiotic use, pulse steroid use, and being 60 years and older were found to be risk factors for mortality and ICU admission. Conclusion: Overusing antibiotics in COVID-19 patients did not have a positive effect on mortality and ICU requirements. Considering the harms of excessive antibiotic use, recommendations and practices that lead to rational antibiotic use are needed. Furthermore, factors predicting mortality and ICU can be used in clinical practice.

 Amaç: Koronavirüs hastalığı 2019 coronavirus disease 2019, COVID-19 pandemisinin antibiyotik yönetimi üzerinde doğrudan bir etkisi olmuştur ve olmaya devam etmektedir. Bu çalışmanın amacı, COVID-19 hastalarında antibiyotik kullanımı ve bunun yoğun bakım ünitesine YBÜ yatış ve mortalite üzerindeki etkisini değerlendirmektir. Gereç ve Yöntemler: Enfeksiyonun klinik bulguları olan ve serviste takip edilen 18 yaş 324 COVID-19 hastasının tıbbi kayıtları geriye dönük olarak değerlendirildi. Hastalar antibiyotik tedavisi alanlar ve almayan olmak üzere iki ayrı gruba ayrıldı. YBÜden servise devredilen, birinci gün taburcu edilen veya eksik verisi olan hastalar çalışma dışı bırakıldı. Bulgular: Hastaların 172si 53,1 erkek, 152si 46,9 kadın ve 212si 65,4 antibiyotik tedavisi almıştı. Bir haftadan uzun hastanede yatış p0,001, pulse steroid kullanımı p0,011, yoğun bakım yatışı p0,002 ve mortalite p0,001 antibiyotik kullanan hastalarda anlamlı olarak daha yüksekti. Antibiyotik kullanan hastalarda yatışta ve 48-72. saatlerde elde edilen CRP p0,001, PCT p0,001 ve ferritin p0,017 değerleri de daha yüksek bulunurken, taburculuktaki CRP değeri p0,052 açısından fark yoktu. Hastanede yatış süresi, antibiyotik kullanımı, pulse steroid kullanımı ve 60 yaş ve üzeri olmak mortalite ve YBÜ yatış için risk faktörleri olarak bulunmuştur. Sonuç: COVID-19 hastalarında aşırı antibiyotik kullanımının, mortalite ve YBÜ gereksinimi üzerinde olumlu bir etkisi olmamıştır. Aşırı antibiyotik kullanımının zararları göz önüne alınarak akılcı antibiyotik kullanımına yönlendiren öneri ve uygulamalara ihtiyaç vardır. Bununla birlikte mortalite ve YBÜ yatışı yordayan faktörlerin klinik pratikte kullanımı fayda sağlayabilir.

Makale detayları

The Effect of Antibiotic Use on Intensive Care Unit Admission and Mortality in Inpatients with COVID-19 Diagnosis

Yazarlar:

Taliha Karakök | Ahmet Doğan | Onur Acar

Yayıncı:

Duzce University

Ana Başlıklar:

Infectious Diseases | Clinical Microbiology

Dergi:

Duzce Medical Journal Vol.27 Issue 1, pp.17-22

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338373

pISSN:

1307-671X

antibiotic

COVID-19

intensive care unit

mortalityantibiyotik

COVID-19

yoğun bakım ünitesi

mortalite

Sayı

Makale detayları

Yazarlar: Taliha Karakök | Ahmet Doğan | Onur Acar

Yayıncı: Duzce University

Ana Başlıklar: Infectious Diseases | Clinical Microbiology

Dergi: Duzce Medical Journal Vol.27 Issue 1, pp.17-22

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001338373

pISSN: 1307-671X

Sayı

Yazarlar:

Taliha Karakök | Ahmet Doğan | Onur Acar

Yayıncı:

Duzce University

Ana Başlıklar:

Infectious Diseases | Clinical Microbiology

Dergi:

Duzce Medical Journal Vol.27 Issue 1, pp.17-22

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338373

pISSN:

1307-671X