Protective effects of saffron, safranal and crocin administration on vitamins (A, D, E, K) and protein carbonyl levels against CCI4- induced oxidative damage in rats

Ahmet Bakır; Damla Yıldız; Suat Ekin; Gokhan Oto; İrfan Bayram

Makale detayları

Protective effects of saffron, safranal and crocin administration on vitamins (A, D, E, K) and protein carbonyl levels against CCI4- induced oxidative damage in rats

Yazarlar:

Ahmet Bakır | Damla Yıldız | Suat Ekin | Gokhan Oto | İrfan Bayram

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.37 Issue 3, pp.344-352

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330821

pISSN:

1019-1941

Anahtar kelimeler:

Özet:

 Objective: The possible effects of saffron and its active components on oxidative stress are known. Protein carbonyls PCO, formed due to protein exposure to oxidizing agents, are a newly researched topic. In this study, it was aimed to determine, antioxidant fatsoluble vitamins A, D, E, K and PCO values after saffron, safranal and crocin administration with carbon tetrachloride CCl4 in rats. Materials and Methods: Fifty-four Wistar albino male rats were randomly selected, and 9 groups of n6 were formed. Vitamin levels in rat serum were determined by HPLC and PCO levels were determined by spectrophotometric method. Results: A significant difference p0.01 was found between the CCl4 and the saffron, safranal and crocin groups. A significant decrease was observed in retinol and cholecalciferol values between CCl4 and saffron group p0.05, p0.001, and a significant decrease in cholecalciferol and phylloquinone levels between CCl4 and safranal groups p0.01, p0.05. Moreover, a decrease in cholecalciferol level p0.05 was determined between the olive oil, saffron and CCl4crocin groups. Conclusion: As a result, saffron and safranal have a protective effect against CCl4-induced oxidative damage to PCO, retinol, phylloquinone and cholecalciferol, and this effect may be due to the potent antioxidative effects of saffron and safranal.

 Objective: The possible effects of saffron and its active components on oxidative stress are known. Protein carbonyls PCO, formed due to protein exposure to oxidizing agents, are a newly researched topic. In this study, it was aimed to determine, antioxidant fatsoluble vitamins A, D, E, K and PCO values after saffron, safranal and crocin administration with carbon tetrachloride CCl4 in rats. Materials and Methods: Fifty-four Wistar albino male rats were randomly selected, and 9 groups of n6 were formed. Vitamin levels in rat serum were determined by HPLC and PCO levels were determined by spectrophotometric method. Results: A significant difference p0.01 was found between the CCl4 and the saffron, safranal and crocin groups. A significant decrease was observed in retinol and cholecalciferol values between CCl4 and saffron group p0.05, p0.001, and a significant decrease in cholecalciferol and phylloquinone levels between CCl4 and safranal groups p0.01, p0.05. Moreover, a decrease in cholecalciferol level p0.05 was determined between the olive oil, saffron and CCl4crocin groups. Conclusion: As a result, saffron and safranal have a protective effect against CCl4-induced oxidative damage to PCO, retinol, phylloquinone and cholecalciferol, and this effect may be due to the potent antioxidative effects of saffron and safranal.

 Objective: The possible effects of saffron and its active components on oxidative stress are known. Protein carbonyls PCO, formed due to protein exposure to oxidizing agents, are a newly researched topic. In this study, it was aimed to determine, antioxidant fatsoluble vitamins A, D, E, K and PCO values after saffron, safranal and crocin administration with carbon tetrachloride CCl4 in rats. Materials and Methods: Fifty-four Wistar albino male rats were randomly selected, and 9 groups of n6 were formed. Vitamin levels in rat serum were determined by HPLC and PCO levels were determined by spectrophotometric method. Results: A significant difference p0.01 was found between the CCl4 and the saffron, safranal and crocin groups. A significant decrease was observed in retinol and cholecalciferol values between CCl4 and saffron group p0.05, p0.001, and a significant decrease in cholecalciferol and phylloquinone levels between CCl4 and safranal groups p0.01, p0.05. Moreover, a decrease in cholecalciferol level p0.05 was determined between the olive oil, saffron and CCl4crocin groups. Conclusion: As a result, saffron and safranal have a protective effect against CCl4-induced oxidative damage to PCO, retinol, phylloquinone and cholecalciferol, and this effect may be due to the potent antioxidative effects of saffron and safranal.

 Objective: The possible effects of saffron and its active components on oxidative stress are known. Protein carbonyls PCO, formed due to protein exposure to oxidizing agents, are a newly researched topic. In this study, it was aimed to determine, antioxidant fatsoluble vitamins A, D, E, K and PCO values after saffron, safranal and crocin administration with carbon tetrachloride CCl4 in rats. Materials and Methods: Fifty-four Wistar albino male rats were randomly selected, and 9 groups of n6 were formed. Vitamin levels in rat serum were determined by HPLC and PCO levels were determined by spectrophotometric method. Results: A significant difference p0.01 was found between the CCl4 and the saffron, safranal and crocin groups. A significant decrease was observed in retinol and cholecalciferol values between CCl4 and saffron group p0.05, p0.001, and a significant decrease in cholecalciferol and phylloquinone levels between CCl4 and safranal groups p0.01, p0.05. Moreover, a decrease in cholecalciferol level p0.05 was determined between the olive oil, saffron and CCl4crocin groups. Conclusion: As a result, saffron and safranal have a protective effect against CCl4-induced oxidative damage to PCO, retinol, phylloquinone and cholecalciferol, and this effect may be due to the potent antioxidative effects of saffron and safranal.

Makale detayları

Protective effects of saffron, safranal and crocin administration on vitamins (A, D, E, K) and protein carbonyl levels against CCI4- induced oxidative damage in rats

Yazarlar:

Ahmet Bakır | Damla Yıldız | Suat Ekin | Gokhan Oto | İrfan Bayram

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.37 Issue 3, pp.344-352

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330821

pISSN:

1019-1941

Carbon tetrachloride

Protein carbonyl

Saffron

Safranal

Vitamin

Sayı

Makale detayları

Protective effects of saffron, safranal and crocin administration on vitamins (A, D, E, K) and protein carbonyl levels against CCI4- induced oxidative damage in rats

Yazarlar: Ahmet Bakır | Damla Yıldız | Suat Ekin | Gokhan Oto | İrfan Bayram

Yayıncı: Marmara University

Ana Başlıklar: Surgery (Other)

Dergi: Marmara Medical Journal Vol.37 Issue 3, pp.344-352

Belge Tipi: Makale

Yayın Tarihi: 10/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001330821

pISSN: 1019-1941

Carbon tetrachloride

Protein carbonyl

Saffron

Safranal

Vitamin

Sayı

Yazarlar:

Ahmet Bakır | Damla Yıldız | Suat Ekin | Gokhan Oto | İrfan Bayram

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.37 Issue 3, pp.344-352

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330821

pISSN:

1019-1941