Assessment of procalcitonin and other inflammatory markers in peritoneal dialysis-related peritonitis*

Reyhan ÖZTÜRK; Gül R. YILMAZ; Cemal BULUT; Hülya PARPUCU; Sami KINIKLI; Murat DURANAY; Ali Pekcan DEMİRÖZ

Makale detayları

Assessment of procalcitonin and other inflammatory markers in peritoneal dialysis-related peritonitis*

Yazarlar:

Reyhan ÖZTÜRK | Gül R. YILMAZ | Cemal BULUT | Hülya PARPUCU | Sami KINIKLI | Murat DURANAY | Ali Pekcan DEMİRÖZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 2, pp.199-206

Belge Tipi:

Makale

Yayın Tarihi:

1/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755130

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

It is demonstrated that in end-stage renal failure without an infectious pathology conventional laboratory parameters such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) or other acute-phase proteins increase non-specifically. We aimed to evaluate procalcitonin (PCT) and other inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in patients with continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis.  Materials and methods: A case-control study was conducted in a 600-bed tertiary hospital. Fifty patients with CAPD-related peritonitis constituting the study group and 50 CAPD patients without infection as the control group were included in the study between February 2006 and July 2006. Baseline serum WBC count, PCT, ESR, and CRP levels were determined in all patients.    Results: Fifty-six peritonitis episodes were detected in 50 patients. The mean ESR and CRP levels were significantly higher in the study group (P  0.5 ng/mL in 21 of the 50 patients (42%) in the study group and 8 of the 50 patients (16%) in the control group. The positive predictive value was 100% for CRP levels higher than 5 mg/dL and PCT levels higher than 2 ng/mL. The sensitivities were calculated as 40% and 14% by the same cut-off levels for CRP and PCT, respectively.  Conclusion: Serum CRP level is a significant and valuable parameter for detecting inflammation, and determining a new cut-off point for CRP will increase its usefulness in patients with CAPD-related peritonitis. The sensitivity and specificity of PCT were not superior to CRP in peritoneal dialysis-related peritonitis.

 

It is demonstrated that in end-stage renal failure without an infectious pathology conventional laboratory parameters such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) or other acute-phase proteins increase non-specifically. We aimed to evaluate procalcitonin (PCT) and other inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in patients with continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis.  Materials and methods: A case-control study was conducted in a 600-bed tertiary hospital. Fifty patients with CAPD-related peritonitis constituting the study group and 50 CAPD patients without infection as the control group were included in the study between February 2006 and July 2006. Baseline serum WBC count, PCT, ESR, and CRP levels were determined in all patients.    Results: Fifty-six peritonitis episodes were detected in 50 patients. The mean ESR and CRP levels were significantly higher in the study group (P  0.5 ng/mL in 21 of the 50 patients (42%) in the study group and 8 of the 50 patients (16%) in the control group. The positive predictive value was 100% for CRP levels higher than 5 mg/dL and PCT levels higher than 2 ng/mL. The sensitivities were calculated as 40% and 14% by the same cut-off levels for CRP and PCT, respectively.  Conclusion: Serum CRP level is a significant and valuable parameter for detecting inflammation, and determining a new cut-off point for CRP will increase its usefulness in patients with CAPD-related peritonitis. The sensitivity and specificity of PCT were not superior to CRP in peritoneal dialysis-related peritonitis.

Makale detayları

Assessment of procalcitonin and other inflammatory markers in peritoneal dialysis-related peritonitis*

Yazarlar:

Reyhan ÖZTÜRK | Gül R. YILMAZ | Cemal BULUT | Hülya PARPUCU | Sami KINIKLI | Murat DURANAY | Ali Pekcan DEMİRÖZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 2, pp.199-206

Belge Tipi:

Makale

Yayın Tarihi:

1/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755130

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Procalcitonin

C-reactive protein

peritonitis

inflammation markers

Sayı

Makale detayları

Assessment of procalcitonin and other inflammatory markers in peritoneal dialysis-related peritonitis*

Yazarlar: Reyhan ÖZTÜRK | Gül R. YILMAZ | Cemal BULUT | Hülya PARPUCU | Sami KINIKLI | Murat DURANAY | Ali Pekcan DEMİRÖZ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2010 Vol.40 Issue 2, pp.199-206

Belge Tipi: Makale

Yayın Tarihi: 1/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000755130

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Procalcitonin

C-reactive protein

peritonitis

inflammation markers

Sayı

Yazarlar:

Reyhan ÖZTÜRK | Gül R. YILMAZ | Cemal BULUT | Hülya PARPUCU | Sami KINIKLI | Murat DURANAY | Ali Pekcan DEMİRÖZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 2, pp.199-206

Belge Tipi:

Makale

Yayın Tarihi:

1/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755130

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144