Diagnostic performance of ultrasound versus 99mTc-sestamibi scintigraphy in preoperative depiction and localization of parathyroid adenoma in patients with primary hyperparathyroidism

Ercüment Gürlüler

Makale detayları

Diagnostic performance of ultrasound versus 99mTc-sestamibi scintigraphy in preoperative depiction and localization of parathyroid adenoma in patients with primary hyperparathyroidism

Yazarlar:

Ercüment Gürlüler

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

General Surgery

Dergi:

The European Research Journal Vol.11 Issue 1, pp.88-97

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001335640

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: To evaluate diagnostic performance of ultrasound US and 99mTc-sestamibi scintigraphy MIBI in preoperative depiction and localization of parathyroid adenoma in patients with primary hyperparathyroidism PHPT Methods: A total of 645 patients mean age: 52.3 range; 18-81 years, 72.9 were females who underwent parathyroidectomy for PHPT due to histopathologically-confirmed adenoma were included in this retrospective cohort study. The accuracy of preoperative US and MIBI in the depiction and localization of parathyroid adenomas was evaluated with respect to intraoperative localization. Results: Preoperative MIBI was more accurate than preoperative US in identifying upper right 6.2 vs. 2.6 and upper left 7.5 vs. 3.8 orthotopic adenomas, and ectopic adenomas 1.5 vs. 0.7. Failure to identify an adenoma was less commonly noted on preoperative MIBI than on preoperative US 26.9 vs. 32.8. The US mainly failed to diagnose the adenomas located in the upper left 27.4, lower left 25.9 and upper right 19.3 orthotopic sites, while MIBI mainly missed those located in the lower left 36.2, lower right 24.7 and upper left 20.1 orthotopic sites. True-positive depiction rates on the preoperative US 60.4 for 250 mg, 80.3 for 901 mg and MIBI 56.7 for 250 mg, 86.7 for 901 mg were increased as the parathyroid weight increased. Conclusions: Our findings indicate inconclusive results in the identification of parathyroid adenoma in nearly one-third of cases with both US and MIBI and the side-specific and site-specific variations in their performance. Hence, the combined use of these imaging modalities may be of great clinical value in the precise preoperative depiction and localization of parathyroid adenomas.

 Objectives: To evaluate diagnostic performance of ultrasound US and 99mTc-sestamibi scintigraphy MIBI in preoperative depiction and localization of parathyroid adenoma in patients with primary hyperparathyroidism PHPT Methods: A total of 645 patients mean age: 52.3 range; 18-81 years, 72.9 were females who underwent parathyroidectomy for PHPT due to histopathologically-confirmed adenoma were included in this retrospective cohort study. The accuracy of preoperative US and MIBI in the depiction and localization of parathyroid adenomas was evaluated with respect to intraoperative localization. Results: Preoperative MIBI was more accurate than preoperative US in identifying upper right 6.2 vs. 2.6 and upper left 7.5 vs. 3.8 orthotopic adenomas, and ectopic adenomas 1.5 vs. 0.7. Failure to identify an adenoma was less commonly noted on preoperative MIBI than on preoperative US 26.9 vs. 32.8. The US mainly failed to diagnose the adenomas located in the upper left 27.4, lower left 25.9 and upper right 19.3 orthotopic sites, while MIBI mainly missed those located in the lower left 36.2, lower right 24.7 and upper left 20.1 orthotopic sites. True-positive depiction rates on the preoperative US 60.4 for 250 mg, 80.3 for 901 mg and MIBI 56.7 for 250 mg, 86.7 for 901 mg were increased as the parathyroid weight increased. Conclusions: Our findings indicate inconclusive results in the identification of parathyroid adenoma in nearly one-third of cases with both US and MIBI and the side-specific and site-specific variations in their performance. Hence, the combined use of these imaging modalities may be of great clinical value in the precise preoperative depiction and localization of parathyroid adenomas.

 Objectives: To evaluate diagnostic performance of ultrasound US and 99mTc-sestamibi scintigraphy MIBI in preoperative depiction and localization of parathyroid adenoma in patients with primary hyperparathyroidism PHPT Methods: A total of 645 patients mean age: 52.3 range; 18-81 years, 72.9 were females who underwent parathyroidectomy for PHPT due to histopathologically-confirmed adenoma were included in this retrospective cohort study. The accuracy of preoperative US and MIBI in the depiction and localization of parathyroid adenomas was evaluated with respect to intraoperative localization. Results: Preoperative MIBI was more accurate than preoperative US in identifying upper right 6.2 vs. 2.6 and upper left 7.5 vs. 3.8 orthotopic adenomas, and ectopic adenomas 1.5 vs. 0.7. Failure to identify an adenoma was less commonly noted on preoperative MIBI than on preoperative US 26.9 vs. 32.8. The US mainly failed to diagnose the adenomas located in the upper left 27.4, lower left 25.9 and upper right 19.3 orthotopic sites, while MIBI mainly missed those located in the lower left 36.2, lower right 24.7 and upper left 20.1 orthotopic sites. True-positive depiction rates on the preoperative US 60.4 for 250 mg, 80.3 for 901 mg and MIBI 56.7 for 250 mg, 86.7 for 901 mg were increased as the parathyroid weight increased. Conclusions: Our findings indicate inconclusive results in the identification of parathyroid adenoma in nearly one-third of cases with both US and MIBI and the side-specific and site-specific variations in their performance. Hence, the combined use of these imaging modalities may be of great clinical value in the precise preoperative depiction and localization of parathyroid adenomas.

 Objectives: To evaluate diagnostic performance of ultrasound US and 99mTc-sestamibi scintigraphy MIBI in preoperative depiction and localization of parathyroid adenoma in patients with primary hyperparathyroidism PHPT Methods: A total of 645 patients mean age: 52.3 range; 18-81 years, 72.9 were females who underwent parathyroidectomy for PHPT due to histopathologically-confirmed adenoma were included in this retrospective cohort study. The accuracy of preoperative US and MIBI in the depiction and localization of parathyroid adenomas was evaluated with respect to intraoperative localization. Results: Preoperative MIBI was more accurate than preoperative US in identifying upper right 6.2 vs. 2.6 and upper left 7.5 vs. 3.8 orthotopic adenomas, and ectopic adenomas 1.5 vs. 0.7. Failure to identify an adenoma was less commonly noted on preoperative MIBI than on preoperative US 26.9 vs. 32.8. The US mainly failed to diagnose the adenomas located in the upper left 27.4, lower left 25.9 and upper right 19.3 orthotopic sites, while MIBI mainly missed those located in the lower left 36.2, lower right 24.7 and upper left 20.1 orthotopic sites. True-positive depiction rates on the preoperative US 60.4 for 250 mg, 80.3 for 901 mg and MIBI 56.7 for 250 mg, 86.7 for 901 mg were increased as the parathyroid weight increased. Conclusions: Our findings indicate inconclusive results in the identification of parathyroid adenoma in nearly one-third of cases with both US and MIBI and the side-specific and site-specific variations in their performance. Hence, the combined use of these imaging modalities may be of great clinical value in the precise preoperative depiction and localization of parathyroid adenomas.

Makale detayları

Diagnostic performance of ultrasound versus 99mTc-sestamibi scintigraphy in preoperative depiction and localization of parathyroid adenoma in patients with primary hyperparathyroidism

Yazarlar:

Ercüment Gürlüler

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

General Surgery

Dergi:

The European Research Journal Vol.11 Issue 1, pp.88-97

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001335640

pISSN:

2149-3189

Primary hyperparathyroidism

preoperative imaging

ultrasound

99mTc-sestamibi scintigraphy

parathyroid adenoma

localization

Sayı

Makale detayları

Diagnostic performance of ultrasound versus 99mTc-sestamibi scintigraphy in preoperative depiction and localization of parathyroid adenoma in patients with primary hyperparathyroidism

Yazarlar: Ercüment Gürlüler

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: General Surgery

Dergi: The European Research Journal Vol.11 Issue 1, pp.88-97

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001335640

pISSN: 2149-3189

Primary hyperparathyroidism

preoperative imaging

ultrasound

99mTc-sestamibi scintigraphy

parathyroid adenoma

localization

Sayı

Yazarlar:

Ercüment Gürlüler

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

General Surgery

Dergi:

The European Research Journal Vol.11 Issue 1, pp.88-97

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001335640

pISSN:

2149-3189