Optimal cytoreduction is the only independent prognostic factor for survival in women with ovarian clear cell carcinoma

Ulas SOLMAZ; Emre MAT; Atalay EKİN; Levent DERELİ; Özgür TURAN; Gulsah DEMİRTAS; Cenk GEZER; Pinar HASDEMİR; Sevil SAYHAN; Muzaffer SANCİ

Makale detayları

Optimal cytoreduction is the only independent prognostic factor for survival in women with ovarian clear cell carcinoma

Yazarlar:

Ulas SOLMAZ | Emre MAT | Atalay EKİN | Levent DERELİ | Özgür TURAN | Gulsah DEMİRTAS | Cenk GEZER | Pinar HASDEMİR | Sevil SAYHAN | Muzaffer SANCİ

Yayıncı:

Zafer AKAN

Dergi:

Medical Science and Discovery 2015 Vol.2 Issue 6, pp.345-51

Belge Tipi:

Makale

Yayın Tarihi:

9/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000826902

Sıklık:

Aylık

eISSN:

2148-6832

pISSN:

2148-6832

Özet:

 


Objective: To evaluate the clinicopathological characteristics, treatment methods, survival, and prognosis of ovarian clear-cell carcinoma (OCCC).

Material and Methods: All patients with OCCC who were treated between January 1998 and October 2012 were retrospectively reviewed. After the exclusion criteria, a total of 39 women were included in the present study. Univariate and multivariate analyses were used to identify the risk factors for overall survival (OS) and progression-free survival (PFS).

Results: The majority of the patients were at stage I disease (n=21 [24.3%]). All patients underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Additionally only pelvic, and pelvic plus para-aortic lymphadenectomy was done in 8 (20.5%) and 19 (48.8%) women, respectively. Optimal cytoreductive surgery was achieved in 26 (66.7%) patients. Recurrences occurred in 11 (28.2%) patients. The median follow-up period was 51 months (range 4 – 132 months). The 5-year PFS and OS rates were 47% and 54%, for all patients. The 5-year OS rates for women with early (stage I and II) and advanced (stage III and IV) stage disease were 56.4% and 38.1%, respectively. Multivariate analysis confirmed optimal cytoreduction as the only independent predictor of OS [Odds ratio (OR) 21.212, 95% confidence interval (CI) 5.259–85.556, (p<0.001)]

Conclusion: Optimal cytoreductive surgery is the only independent good prognostic factor for survival in patients with OCCC.

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Makale detayları

Optimal cytoreduction is the only independent prognostic factor for survival in women with ovarian clear cell carcinoma

Yazarlar: Ulas SOLMAZ | Emre MAT | Atalay EKİN | Levent DERELİ | Özgür TURAN | Gulsah DEMİRTAS | Cenk GEZER | Pinar HASDEMİR | Sevil SAYHAN | Muzaffer SANCİ

Yayıncı: Zafer AKAN

Dergi: Medical Science and Discovery 2015 Vol.2 Issue 6, pp.345-51

Belge Tipi: Makale

Yayın Tarihi: 9/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000826902

Sıklık: Aylık

eISSN: 2148-6832

pISSN: 2148-6832

Sayı

Yazarlar:

Ulas SOLMAZ | Emre MAT | Atalay EKİN | Levent DERELİ | Özgür TURAN | Gulsah DEMİRTAS | Cenk GEZER | Pinar HASDEMİR | Sevil SAYHAN | Muzaffer SANCİ

Yayıncı:

Zafer AKAN

Dergi:

Medical Science and Discovery 2015 Vol.2 Issue 6, pp.345-51

Belge Tipi:

Makale

Yayın Tarihi:

9/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000826902

Sıklık:

Aylık

eISSN:

2148-6832

pISSN:

2148-6832