Association between fetal growth restriction and late complications in long-term survivors of pediatric acute lymphoblastic leukemia

Burçak Kurucu; Gürses Şahin

Makale detayları

Association between fetal growth restriction and late complications in long-term survivors of pediatric acute lymphoblastic leukemia

Yazarlar:

Burçak Kurucu | Gürses Şahin

Yayıncı:

Cukurova University

Ana Başlıklar:

Çocuk Hematolojisi ve Onkolojisi

Dergi:

Cukurova Medical Journal Vol.50 Issue 3, pp.561-564

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357831

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: This study aimed to investigate the association between fetal growth restriction FGR and the development of late complications in long-term survivors of pediatric acute lymphoblastic leukemia ALL. Materials and Methods: This study enrolled 108 long-term survivors of pediatric ALL, who were subsequently divided into two groups. Group 1 consisted of 48 patients with a history of FGR, while Group 2 included 60 patients with normal fetal growth. The groups were compared based on demographic characteristics, treatment status, duration of remission, maternal and paternal age at conception, maternal weight gain during pregnancy, parental smoking and alcohol use, and the incidence of late complications. Results: No significant association was found between the groups regarding treatment status, demographic factors, remission duration, or familial risk factors. However, the number of late complications was statistically significantly higher in Group 1 3748, 77.1 compared to Group 2 1860, 30.0. The most frequently observed late complications were endocrine 47108, cardiac 21108, osseous 18108, metabolic 8108, and neurological 3108. Conclusion: ALL treatment may induce late complications by affecting various systems and tissues through oxidative mechanisms, particularly in patients with a history of FGR. Our findings may aid clinicians in predicting the risk of late complications and developing early prevention strategies for ALL survivors with a history of FGR.

 Purpose: This study aimed to investigate the association between fetal growth restriction FGR and the development of late complications in long-term survivors of pediatric acute lymphoblastic leukemia ALL. Materials and Methods: This study enrolled 108 long-term survivors of pediatric ALL, who were subsequently divided into two groups. Group 1 consisted of 48 patients with a history of FGR, while Group 2 included 60 patients with normal fetal growth. The groups were compared based on demographic characteristics, treatment status, duration of remission, maternal and paternal age at conception, maternal weight gain during pregnancy, parental smoking and alcohol use, and the incidence of late complications. Results: No significant association was found between the groups regarding treatment status, demographic factors, remission duration, or familial risk factors. However, the number of late complications was statistically significantly higher in Group 1 3748, 77.1 compared to Group 2 1860, 30.0. The most frequently observed late complications were endocrine 47108, cardiac 21108, osseous 18108, metabolic 8108, and neurological 3108. Conclusion: ALL treatment may induce late complications by affecting various systems and tissues through oxidative mechanisms, particularly in patients with a history of FGR. Our findings may aid clinicians in predicting the risk of late complications and developing early prevention strategies for ALL survivors with a history of FGR.

 Purpose: This study aimed to investigate the association between fetal growth restriction FGR and the development of late complications in long-term survivors of pediatric acute lymphoblastic leukemia ALL. Materials and Methods: This study enrolled 108 long-term survivors of pediatric ALL, who were subsequently divided into two groups. Group 1 consisted of 48 patients with a history of FGR, while Group 2 included 60 patients with normal fetal growth. The groups were compared based on demographic characteristics, treatment status, duration of remission, maternal and paternal age at conception, maternal weight gain during pregnancy, parental smoking and alcohol use, and the incidence of late complications. Results: No significant association was found between the groups regarding treatment status, demographic factors, remission duration, or familial risk factors. However, the number of late complications was statistically significantly higher in Group 1 3748, 77.1 compared to Group 2 1860, 30.0. The most frequently observed late complications were endocrine 47108, cardiac 21108, osseous 18108, metabolic 8108, and neurological 3108. Conclusion: ALL treatment may induce late complications by affecting various systems and tissues through oxidative mechanisms, particularly in patients with a history of FGR. Our findings may aid clinicians in predicting the risk of late complications and developing early prevention strategies for ALL survivors with a history of FGR.

 Amaç: Pediatrik akut lenfoblastik lösemininALL uzun dönem sağ kalanlarında fetal büyüme geriliği FBG ile geç komplikasyonlar arasındaki ilişkiyi araştırdık. Gereç ve Yöntem: Çalışmada, pediatrik ALL hastalarından uzun dönem sağ kalan 108 hasta ; FBGye grup 1, n48 ve normal büyümeye grup 2, n60 göre iki gruba ayrıldı. Gruplar tedavi durumu, demografik özellikler, remisyon süresi, maternal gebelik yaşı, paternal gebe kalma yaşı, gebelik sırasında maternal kilo alımı, ebeveynlerin sigara ve alkol tüketimi ve geç komplikasyonlar açısından değerlendirildi. Bulgular: Çalışmada hastaların tedavi durumu, demografik faktörler, remisyon süresi ve ailevi risk faktörleri arasında bir ilişki bulunmadı. Geç komplikasyon sayısı grup 1de 3748, 77,1 grup 2ye 1860, 30,0 göre istatistiksel olarak daha yüksekti p0,001. En sık görülen geç komplikasyonlar endokrin 47108, kardiyak 21108, osseöz 18108, metabolik 8108 ve nörolojik 3108 komplikasyonlardı. Sonuç: ALL tedavisi, özellikle FBG öyküsü olan hastalarda, oksidatif mekanizmalarla, çeşitli sistem ve dokuları etkileyerek geç komplikasyonlara neden olabilir. Çalışmamız, FBG öyküsü olan sağ kalanlarda geç komplikasyon riskini ve erken önlemeyi tahmin etmede klinisyenlere fayda sağlayacaktır.

Makale detayları

Association between fetal growth restriction and late complications in long-term survivors of pediatric acute lymphoblastic leukemia

Yazarlar:

Burçak Kurucu | Gürses Şahin

Yayıncı:

Cukurova University

Ana Başlıklar:

Çocuk Hematolojisi ve Onkolojisi

Dergi:

Cukurova Medical Journal Vol.50 Issue 3, pp.561-564

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357831

pISSN:

2602-3032

Fetal growth restriction

acute lymphoblastic leukemia

late complications

childhood

long-term survivorsFetal büyüme geriliği

akut lenfoblastik lösemi

geç komplikasyonlar

çocukluk çağı

uzun dönem sağ kalanlar

Sayı

Makale detayları

Yazarlar: Burçak Kurucu | Gürses Şahin

Yayıncı: Cukurova University

Ana Başlıklar: Çocuk Hematolojisi ve Onkolojisi

Dergi: Cukurova Medical Journal Vol.50 Issue 3, pp.561-564

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357831

pISSN: 2602-3032

Sayı

Yazarlar:

Burçak Kurucu | Gürses Şahin

Yayıncı:

Cukurova University

Ana Başlıklar:

Çocuk Hematolojisi ve Onkolojisi

Dergi:

Cukurova Medical Journal Vol.50 Issue 3, pp.561-564

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357831

pISSN:

2602-3032