An Investigation of Infections Caused by Multidrug Resistant Acinetobacter baumannii in a University Hospital: A 15-year Interval Study on Risk Factors and Prognosis

Emel Azak; Aynur Karadenizli; Haluk Vahaboglu

Makale detayları

An Investigation of Infections Caused by Multidrug Resistant Acinetobacter baumannii in a University Hospital: A 15-year Interval Study on Risk Factors and Prognosis

Yazarlar:

Emel Azak | Aynur Karadenizli | Haluk Vahaboglu

Yayıncı:

Sakarya University

Ana Başlıklar:

Bulaşıcı Hastalıklar

Dergi:

Sakarya Tıp Dergisi Vol.14 Issue 2, pp.149-163

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001318911

pISSN:

2146-409X

Anahtar kelimeler:

Özet:

 Objective: Growing antibiotic resistance and limited treatment options make Acinetobacter baumannii AB in healthcare-associated infections HAI difficult. This study compares MDRAB-related HAI risk factors and prognosis in our hospital over two time periods. Materials and Methods: MDRAB growth patients clinical and microbiological data from May 2002May 2005 Group I and January 2023December 2023 Group II were retrospectively examined. MDRAB-caused HAI risk factors were assessed in case and control groups. Results: This study evaluated 37 cases and 26 controls in Group I and 64 cases and 64 controls in Group II. Most HAIs were respiratory tract infections 54 in Group I and bloodstream infections 57 in Group II. Diabetes p0.010, chronic lung disease p0.007, and prolonged hospital stay p0.004 were risk factors in Group I, while nasogastric tube days p0.044 were in Group II. Group I had more chronic lung disease, prior surgery, surgical unit admission, urinary catheter, and nasogastric tube use than Group II. Group II had higher underlying disease, malignancy, ICU admission, and APACHE II score than Group I. The mortality rate rose from 30 to 45 p0.123, and carbapenem use rose from 43 to 69 p0.012. Group II had 64 tigecycline and 5.4 colistin resistance. Conclusion: The study shows a significant rise in MDRAB-related bloodstream infections, especially in malignancy and ICU patients. High carbapenem use before HAI, rising tigecycline and colistin resistance, and the lack of high-dose tigecycline approval are major issues. The rise in mortality rates makes multifaceted infection control interventions for MDRAB infections necessary.

 Objective: Growing antibiotic resistance and limited treatment options make Acinetobacter baumannii AB in healthcare-associated infections HAI difficult. This study compares MDRAB-related HAI risk factors and prognosis in our hospital over two time periods. Materials and Methods: MDRAB growth patients clinical and microbiological data from May 2002May 2005 Group I and January 2023December 2023 Group II were retrospectively examined. MDRAB-caused HAI risk factors were assessed in case and control groups. Results: This study evaluated 37 cases and 26 controls in Group I and 64 cases and 64 controls in Group II. Most HAIs were respiratory tract infections 54 in Group I and bloodstream infections 57 in Group II. Diabetes p0.010, chronic lung disease p0.007, and prolonged hospital stay p0.004 were risk factors in Group I, while nasogastric tube days p0.044 were in Group II. Group I had more chronic lung disease, prior surgery, surgical unit admission, urinary catheter, and nasogastric tube use than Group II. Group II had higher underlying disease, malignancy, ICU admission, and APACHE II score than Group I. The mortality rate rose from 30 to 45 p0.123, and carbapenem use rose from 43 to 69 p0.012. Group II had 64 tigecycline and 5.4 colistin resistance. Conclusion: The study shows a significant rise in MDRAB-related bloodstream infections, especially in malignancy and ICU patients. High carbapenem use before HAI, rising tigecycline and colistin resistance, and the lack of high-dose tigecycline approval are major issues. The rise in mortality rates makes multifaceted infection control interventions for MDRAB infections necessary.

 Objective: Growing antibiotic resistance and limited treatment options make Acinetobacter baumannii AB in healthcare-associated infections HAI difficult. This study compares MDRAB-related HAI risk factors and prognosis in our hospital over two time periods. Materials and Methods: MDRAB growth patients clinical and microbiological data from May 2002May 2005 Group I and January 2023December 2023 Group II were retrospectively examined. MDRAB-caused HAI risk factors were assessed in case and control groups. Results: This study evaluated 37 cases and 26 controls in Group I and 64 cases and 64 controls in Group II. Most HAIs were respiratory tract infections 54 in Group I and bloodstream infections 57 in Group II. Diabetes p0.010, chronic lung disease p0.007, and prolonged hospital stay p0.004 were risk factors in Group I, while nasogastric tube days p0.044 were in Group II. Group I had more chronic lung disease, prior surgery, surgical unit admission, urinary catheter, and nasogastric tube use than Group II. Group II had higher underlying disease, malignancy, ICU admission, and APACHE II score than Group I. The mortality rate rose from 30 to 45 p0.123, and carbapenem use rose from 43 to 69 p0.012. Group II had 64 tigecycline and 5.4 colistin resistance. Conclusion: The study shows a significant rise in MDRAB-related bloodstream infections, especially in malignancy and ICU patients. High carbapenem use before HAI, rising tigecycline and colistin resistance, and the lack of high-dose tigecycline approval are major issues. The rise in mortality rates makes multifaceted infection control interventions for MDRAB infections necessary.

 Amaç: Sağlık bakımı ilişkili enfeksiyonlarda SBİE Acinetobacter baumannii AB, yüksek antibiyotik direnç oranları nedeniyle önemli bir sorundur. Bu çalışmada, çoklu ilaca dirençli AB ÇİDAB SBİElerinin, risk faktörlerinin ve prognozun iki farklı zaman diliminde değerlendirilmesi amaçlandı. Gereç ve Yöntemler: Mayıs 2002-Mayıs 2005 Grup I ve Ocak 2023-Aralık 2023 Grup II tarihleri arasında, ÇİDAB üremesi olan hastaların klinik ve mikrobiyolojik verileri, retrospektif olarak değerlendirildi. ÇİDAB SBİElerinin gelişimine ait risk faktörlerini değerlendirmek için, vaka ve kontrol grupları oluşturuldu. Bulgular: Grup Ide 37 vaka ve 26 kontrol hastası, Grup IIde 64 vaka ve 64 kontrol hastası değerlendirildi. En sık SBİEler, Grup Ide solunum yolu 54, Grup IIde kan dolaşımı 57 enfeksiyonlarıydı. Grup Ide diyabet p0,010, kronik akciğer hastalığı p0,007 ve hastanede uzun yatış süresi p0,004, Grup IIde ise nazogastrik tüp günü p0,044 risk faktörü olarak saptandı. Grup Ide kronik akciğer hastalığı, geçirilmiş cerrahi, cerrahi birimlerde yatış, üriner kateter ve nazogastrik tüp kullanımı Grup IIden; Grup IIde, altta yatan hastalık, malignite, YBÜye yatış ve APACHE II skoru Grup Iden yüksekti. Grup Iden IIye karbapenem kullanımının 43ten 69a p0,012 ve mortalitenin 30dan 45e p0,123 arttığı saptandı. Grup IIde 64 tigesiklin direnci ve 5,4 kolistin direnci vardı. Sonuç: Bu çalışmada, geçmişten günümüze ÇİDAB ilişkili kan dolaşımı enfeksiyonlarında belirgin artış, malignitesi olan ve YBÜye yatan hastalarda ÇİDAB enfeksiyonu sıklığı dikkat çekicidir. SBİE öncesi karbapenem kullanımında artış, tigesiklin ve kolistine artan direnç ve yüksek doz tigesiklin kullanım onayının olmaması önemli sorunlardır. Günümüzde mortalite oranlarındaki artış da dikkate alındığında, ÇİDAB enfeksiyonlarına yönelik çok yönlü enfeksiyon kontrol müdahalelerine gereksinim duyulduğu aşikardır.

Makale detayları

An Investigation of Infections Caused by Multidrug Resistant Acinetobacter baumannii in a University Hospital: A 15-year Interval Study on Risk Factors and Prognosis

Yazarlar:

Emel Azak | Aynur Karadenizli | Haluk Vahaboglu

Yayıncı:

Sakarya University

Ana Başlıklar:

Bulaşıcı Hastalıklar

Dergi:

Sakarya Tıp Dergisi Vol.14 Issue 2, pp.149-163

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001318911

pISSN:

2146-409X

Acinetobacter baumannii

Healthcare associated infection

Multidrug resistance

Risk factors

PrognosisAcinetobacter baumannii

Sağlık bakımı ilişkili enfeksiyon

Çoklu ilaca direnç

Risk faktörleri

Prognoz

Sayı

Makale detayları

Yazarlar: Emel Azak | Aynur Karadenizli | Haluk Vahaboglu

Yayıncı: Sakarya University

Ana Başlıklar: Bulaşıcı Hastalıklar

Dergi: Sakarya Tıp Dergisi Vol.14 Issue 2, pp.149-163

Belge Tipi: Makale

Yayın Tarihi: 6/2024

Belge Dili: Türkçe

Document ID (Org No.): 2001318911

pISSN: 2146-409X

Sayı

Yazarlar:

Emel Azak | Aynur Karadenizli | Haluk Vahaboglu

Yayıncı:

Sakarya University

Ana Başlıklar:

Bulaşıcı Hastalıklar

Dergi:

Sakarya Tıp Dergisi Vol.14 Issue 2, pp.149-163

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001318911

pISSN:

2146-409X