An Efficient Synthesis of (1S, 2R)-1-Amino-2-Indanol, A Key Intermediate of HIV Protease Inhibitor, Indinavir

Ayhan S. DEMİR; Hilal AKSOY-CAM; Nurettin CAMKERTEN

Makale detayları

An Efficient Synthesis of (1S, 2R)-1-Amino-2-Indanol, A Key Intermediate of HIV Protease Inhibitor, Indinavir

Yazarlar:

Ayhan S. DEMİR | Hilal AKSOY-CAM | Nurettin CAMKERTEN

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2000 Vol.24 Issue 2, pp.141-146

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

İngilizce

Document ID (Org No.):

2000730288

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

(1S,2R)-1-amino-2-indanol, a key component of an HIV protease inhibitor is synthesized in four steps starting from indanone. The Mn(OAC)3 mediated acetoxylation of indanone followed by fungus catalyzed hydrolysis of acetoxyindanone furnished optically pure a-hydroxy indanone. Formation and enantioselective reduction of oxime ether of 2-hydroxyindanone afforded (1S, 2R)-1-amino-2-indanol in 97% {\it cis} selectivity.

 

(1S,2R)-1-amino-2-indanol, a key component of an HIV protease inhibitor is synthesized in four steps starting from indanone. The Mn(OAC)3 mediated acetoxylation of indanone followed by fungus catalyzed hydrolysis of acetoxyindanone furnished optically pure a-hydroxy indanone. Formation and enantioselective reduction of oxime ether of 2-hydroxyindanone afforded (1S, 2R)-1-amino-2-indanol in 97% {\it cis} selectivity.

Makale detayları

An Efficient Synthesis of (1S, 2R)-1-Amino-2-Indanol, A Key Intermediate of HIV Protease Inhibitor, Indinavir

Yazarlar: Ayhan S. DEMİR | Hilal AKSOY-CAM | Nurettin CAMKERTEN

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2000 Vol.24 Issue 2, pp.141-146

Belge Tipi: Makale

Yayın Tarihi: 1/2000

Belge Dili: İngilizce

Document ID (Org No.): 2000730288

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Ayhan S. DEMİR | Hilal AKSOY-CAM | Nurettin CAMKERTEN

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2000 Vol.24 Issue 2, pp.141-146

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

İngilizce

Document ID (Org No.):

2000730288

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527