Chemical composition and cytotoxicity of Araucaria heterophylla (Salisb.) franco essential oils

Akinsola Akande; Sherifat Aboaba

Makale detayları

Chemical composition and cytotoxicity of Araucaria heterophylla (Salisb.) franco essential oils

Yazarlar:

Akinsola Akande | Sherifat Aboaba

Yayıncı:

İzzet KARA

Ana Başlıklar:

Natural Products and Bioactive Compounds

Dergi:

International Journal of Secondary Metabolite Vol.12 Issue 1, pp.109-118

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001331130

pISSN:

2148-6905

Anahtar kelimeler:

Özet:

 The Norfolk Island pine, Araucaria heterophylla Salisb. Franco Araucariaceae, is a plant that exhibits several pharmacological potentials. Essential oils EOs from the plants fresh stem bark FRS and dry stem bark DRS were hydrodistilled in an all-glass Clevenger apparatus and further characterized by Gas Chromatography-Mass Spectrometry analysis. Using Artemia salina eggs hatched in sea water, the brine shrimp lethality assay was carried out for toxicity. The FRS and DRS yielded 0.33 and 0.29 EOs, respectively, constituting 48 and 42 compounds, representing 94.38 and 84.30 of the total oil fractions. The classes of compounds identified in the FRS and DRS EOs, respectively, include sesquiterpenes 40.8 and 41.36, oxygenated sesquiterpenes 34.93 and 34.22, oxygenated monoterpenes 11.58 and 2.84, diterpenes 3.39 and 2.85, oxygenated diterpenes 3.68 and 2.29, and oxygenated triterpenes 0.74, only in the DRS. The major constituents in the FRS EOs are spathulenol 12.12, germacrene B 10.63, dihydroedulan I 10.23, γ-cadinene 6.90, --globulol4.67, aromadendrene 3.62 and copaene 3.34 while spathulenol 16.13, germacrene B 10.37, aromadendrene 4.93, copaene 3.54, β-panasinsene 3.06 and guaiol 2.99 majorly constitute the DRS oil. Constituents common and as well dominant in the two EOs include Spathulenol, Germacrene B, Aromadendrene and Copaene. The result of the cytotoxicity analysis showed that both the fresh and dry essential oils have LC50 of 10 ppm. A LC50100 ppm indicates high toxicity, thus, the EOs possess significant cytotoxicity against A. salina.

 The Norfolk Island pine, Araucaria heterophylla Salisb. Franco Araucariaceae, is a plant that exhibits several pharmacological potentials. Essential oils EOs from the plants fresh stem bark FRS and dry stem bark DRS were hydrodistilled in an all-glass Clevenger apparatus and further characterized by Gas Chromatography-Mass Spectrometry analysis. Using Artemia salina eggs hatched in sea water, the brine shrimp lethality assay was carried out for toxicity. The FRS and DRS yielded 0.33 and 0.29 EOs, respectively, constituting 48 and 42 compounds, representing 94.38 and 84.30 of the total oil fractions. The classes of compounds identified in the FRS and DRS EOs, respectively, include sesquiterpenes 40.8 and 41.36, oxygenated sesquiterpenes 34.93 and 34.22, oxygenated monoterpenes 11.58 and 2.84, diterpenes 3.39 and 2.85, oxygenated diterpenes 3.68 and 2.29, and oxygenated triterpenes 0.74, only in the DRS. The major constituents in the FRS EOs are spathulenol 12.12, germacrene B 10.63, dihydroedulan I 10.23, γ-cadinene 6.90, --globulol4.67, aromadendrene 3.62 and copaene 3.34 while spathulenol 16.13, germacrene B 10.37, aromadendrene 4.93, copaene 3.54, β-panasinsene 3.06 and guaiol 2.99 majorly constitute the DRS oil. Constituents common and as well dominant in the two EOs include Spathulenol, Germacrene B, Aromadendrene and Copaene. The result of the cytotoxicity analysis showed that both the fresh and dry essential oils have LC50 of 10 ppm. A LC50100 ppm indicates high toxicity, thus, the EOs possess significant cytotoxicity against A. salina.

 The Norfolk Island pine, Araucaria heterophylla Salisb. Franco Araucariaceae, is a plant that exhibits several pharmacological potentials. Essential oils EOs from the plants fresh stem bark FRS and dry stem bark DRS were hydrodistilled in an all-glass Clevenger apparatus and further characterized by Gas Chromatography-Mass Spectrometry analysis. Using Artemia salina eggs hatched in sea water, the brine shrimp lethality assay was carried out for toxicity. The FRS and DRS yielded 0.33 and 0.29 EOs, respectively, constituting 48 and 42 compounds, representing 94.38 and 84.30 of the total oil fractions. The classes of compounds identified in the FRS and DRS EOs, respectively, include sesquiterpenes 40.8 and 41.36, oxygenated sesquiterpenes 34.93 and 34.22, oxygenated monoterpenes 11.58 and 2.84, diterpenes 3.39 and 2.85, oxygenated diterpenes 3.68 and 2.29, and oxygenated triterpenes 0.74, only in the DRS. The major constituents in the FRS EOs are spathulenol 12.12, germacrene B 10.63, dihydroedulan I 10.23, γ-cadinene 6.90, --globulol4.67, aromadendrene 3.62 and copaene 3.34 while spathulenol 16.13, germacrene B 10.37, aromadendrene 4.93, copaene 3.54, β-panasinsene 3.06 and guaiol 2.99 majorly constitute the DRS oil. Constituents common and as well dominant in the two EOs include Spathulenol, Germacrene B, Aromadendrene and Copaene. The result of the cytotoxicity analysis showed that both the fresh and dry essential oils have LC50 of 10 ppm. A LC50100 ppm indicates high toxicity, thus, the EOs possess significant cytotoxicity against A. salina.

 The Norfolk Island pine, Araucaria heterophylla Salisb. Franco Araucariaceae, is a plant that exhibits several pharmacological potentials. Essential oils EOs from the plants fresh stem bark FRS and dry stem bark DRS were hydrodistilled in an all-glass Clevenger apparatus and further characterized by Gas Chromatography-Mass Spectrometry analysis. Using Artemia salina eggs hatched in sea water, the brine shrimp lethality assay was carried out for toxicity. The FRS and DRS yielded 0.33 and 0.29 EOs, respectively, constituting 48 and 42 compounds, representing 94.38 and 84.30 of the total oil fractions. The classes of compounds identified in the FRS and DRS EOs, respectively, include sesquiterpenes 40.8 and 41.36, oxygenated sesquiterpenes 34.93 and 34.22, oxygenated monoterpenes 11.58 and 2.84, diterpenes 3.39 and 2.85, oxygenated diterpenes 3.68 and 2.29, and oxygenated triterpenes 0.74, only in the DRS. The major constituents in the FRS EOs are spathulenol 12.12, germacrene B 10.63, dihydroedulan I 10.23, γ-cadinene 6.90, --globulol4.67, aromadendrene 3.62 and copaene 3.34 while spathulenol 16.13, germacrene B 10.37, aromadendrene 4.93, copaene 3.54, β-panasinsene 3.06 and guaiol 2.99 majorly constitute the DRS oil. Constituents common and as well dominant in the two EOs include Spathulenol, Germacrene B, Aromadendrene and Copaene. The result of the cytotoxicity analysis showed that both the fresh and dry essential oils have LC50 of 10 ppm. A LC50100 ppm indicates high toxicity, thus, the EOs possess significant cytotoxicity against A. salina.

Makale detayları

Chemical composition and cytotoxicity of Araucaria heterophylla (Salisb.) franco essential oils

Yazarlar:

Akinsola Akande | Sherifat Aboaba

Yayıncı:

İzzet KARA

Ana Başlıklar:

Natural Products and Bioactive Compounds

Dergi:

International Journal of Secondary Metabolite Vol.12 Issue 1, pp.109-118

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001331130

pISSN:

2148-6905

Araucaria heterophylla

GC and GC-MS

Essential oil

Spathulenol

CytotoxicityAraucaria heterophylla

GC and GC-MS

Essential oil

Spathulenol

Cytotoxicity

Sayı

Makale detayları

Yazarlar: Akinsola Akande | Sherifat Aboaba

Yayıncı: İzzet KARA

Ana Başlıklar: Natural Products and Bioactive Compounds

Dergi: International Journal of Secondary Metabolite Vol.12 Issue 1, pp.109-118

Belge Tipi: Makale

Yayın Tarihi: 2/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001331130

pISSN: 2148-6905

Sayı

Yazarlar:

Akinsola Akande | Sherifat Aboaba

Yayıncı:

İzzet KARA

Ana Başlıklar:

Natural Products and Bioactive Compounds

Dergi:

International Journal of Secondary Metabolite Vol.12 Issue 1, pp.109-118

Belge Tipi:

Makale

Yayın Tarihi:

2/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001331130

pISSN:

2148-6905