LONG NON-CODING RNAs AND AUTOPHAGY IN OSTEOSARCOMA

Ayça COŞKUN; Hamza Malik OKUYAN

doi:https://doi.org/10.26650/JARHS2021-1134054

Makale detayları

LONG NON-CODING RNAs AND AUTOPHAGY IN OSTEOSARCOMA

Yazarlar:

Ayça COŞKUN | Hamza Malik OKUYAN

Yayıncı:

Istanbul University

Ana Başlıklar:

Astronomi ve ilgili bilimler | Hastalıklar

Dergi:

Journal of Advanced Research in Health Sciences 2022 Vol.5 Issue S-1, pp.48-48

Belge Tipi:

Makale

Yayın Tarihi:

8/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000615873

Sıklık:

Üç Yıllık

eISSN:

2651-4060

DOI:

https://doi.org/10.26650/JARHS2021-1134054

Özet:

 

Osteosarcoma (OSA) is an aggressive bone tumor that occurs primarily in children and adolescents worldwide, with a high metastatic and recurrence
ability. OSA is characterized by the transformation of mesenchymal cells and the formation of osteoid tissue. Although recent advancements have
improved the current therapeutic management of OSA, the clinical outcomes of the disease still remain unsatisfactory. Therefore, it is important to
determine the novel diagnostic markers and/or therapeutic targets for OSA. Autophagy is a highly conserved self-degradative process that plays a crucial
role in various physiological mechanisms such as survival, homeostasis, development and differentiation. Dysfunction of autophagy is the relationship with
the onset and development of several types of cancer, including OSA. Long non-coding ribonucleic acids (lncRNAs), a group of non-coding RNAs, regulate
various pathophysiological mechanisms such as inflammation, autophagy and apoptosis. Recent studies investigating the role of lncRNAs in the
pathogenesis of OSA have shown that these molecules might have diagnostic and therapeutic importance for the prevention of OSA. Here, we focus on
lncRNAs that modulate autophagy in OSA and discuss the potential clinical values of lncRNAs for OSA. The current study contributes to a better
understanding of OSA pathogenesis and to the development of novel therapeutic approaches for the prevention of OSA.

 

Osteosarcoma (OSA) is an aggressive bone tumor that occurs primarily in children and adolescents worldwide, with a high metastatic and recurrence ability. OSA is characterized by the transformation of mesenchymal cells and the formation of osteoid tissue. Although recent advancements have improved the current therapeutic management of OSA, the clinical outcomes of the disease still remain unsatisfactory. Therefore, it is important to determine the novel diagnostic markers and/or therapeutic targets for OSA. Autophagy is a highly conserved self-degradative process that plays a crucial role in various physiological mechanisms such as survival, homeostasis, development and differentiation. Dysfunction of autophagy is the relationship with the onset and development of several types of cancer, including OSA. Long non-coding ribonucleic acids (lncRNAs), a group of non-coding RNAs, regulate various pathophysiological mechanisms such as inflammation, autophagy and apoptosis. Recent studies investigating the role of lncRNAs in the pathogenesis of OSA have shown that these molecules might have diagnostic and therapeutic importance for the prevention of OSA. Here, we focus on lncRNAs that modulate autophagy in OSA and discuss the potential clinical values of lncRNAs for OSA. The current study contributes to a better understanding of OSA pathogenesis and to the development of novel therapeutic approaches for the prevention of OSA.

Makale detayları

LONG NON-CODING RNAs AND AUTOPHAGY IN OSTEOSARCOMA

Yazarlar: Ayça COŞKUN | Hamza Malik OKUYAN

Yayıncı: Istanbul University

Ana Başlıklar: Astronomi ve ilgili bilimler | Hastalıklar

Dergi: Journal of Advanced Research in Health Sciences 2022 Vol.5 Issue S-1, pp.48-48

Belge Tipi: Makale

Yayın Tarihi: 8/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000615873

Sıklık: Üç Yıllık

eISSN: 2651-4060

DOI: https://doi.org/10.26650/JARHS2021-1134054

Sayı

Yazarlar:

Ayça COŞKUN | Hamza Malik OKUYAN

Yayıncı:

Istanbul University

Ana Başlıklar:

Astronomi ve ilgili bilimler | Hastalıklar

Dergi:

Journal of Advanced Research in Health Sciences 2022 Vol.5 Issue S-1, pp.48-48

Belge Tipi:

Makale

Yayın Tarihi:

8/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000615873

Sıklık:

Üç Yıllık

eISSN:

2651-4060

DOI:

https://doi.org/10.26650/JARHS2021-1134054