Evaluation of the relationship between clinical findings and F responses and diffusion tensor tractography in patients with amyotrophic lateral sclerosis

Pınar Bekdik; Tuba Cerrahoğlu Şirin; Serdar Arslan; Nurten Uzun Adatepe

Makale detayları

Evaluation of the relationship between clinical findings and F responses and diffusion tensor tractography in patients with amyotrophic lateral sclerosis

Yazarlar:

Pınar Bekdik | Tuba Cerrahoğlu Şirin | Serdar Arslan | Nurten Uzun Adatepe

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 1, pp.208-215

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282249

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: The aim of this study is to show whether radiologically diffusion tractography imaging DTI and electrophysiologically F responses methods support clinical examination in Amyotrophic Lateral Sclerosis ALS. It is to determine the relationships between these two methods. Materials and Methods: Patients with a definite diagnosis of ALS according to the Revised-El Escorial and Awaji criteria at any stage of the disease, who applied to the Electromyography EMG laboratory of the Neurology Clinic of Istanbul University Cerrahpaşa, Cerrahpaşa Medical Faculty, prospectively and cross-sectionally, were included in the study. The revised ALS functional rating scale ALSFRS-R was scored. Electrophysiological studies included routine nerve conduction studies, F responses and needle EMG. In radiological examinations, diffusion tractography imaging DTI maps were obtained in brain and cervical Magnetic Resonance Imaging MRI and diffusivity and fractional anisotropy FA values were compared. Results: The mean age of the 12 volunteer patients included in the study was 55.929.68 43-72, and consisted of 4 female and 8 male individuals. The mean ALSFRS-R score was 35.757.86 24-46. MRI was performed in 11 of the patients, spinal imaging could not be performed in one patient. The mean age of the 11 patients who were imaging was 56.49.8 years and the disease duration was 2.71.9 years. Low values of DTI-FA were found to be associated with poor respiratory and speech scores as assessed by linear regression analysis. Repeater F responses in the ulnar nerves were also associated with a high ALSFRS-R score. Conclusion: In our study, we observed that low values of DTI-FA were associated with poor respiratory and speech scores. Showing the correlation of low FA with a vital function such as respiration may indicate that this technique will be helpful in the prognosis and progression of the disease. The increase of repeater F responses in the ulnar nerves in those with high ALSFRS-R scores suggests that it is worth investigating whether ALS can be used in differentiating from other anterior horn diseases. The results of this study suggest that DTI-FA, which is an advanced radiological evaluation, and repeater F responses as an electrophysiological method may support early diagnosis in ALS.

 Purpose: The aim of this study is to show whether radiologically diffusion tractography imaging DTI and electrophysiologically F responses methods support clinical examination in Amyotrophic Lateral Sclerosis ALS. It is to determine the relationships between these two methods. Materials and Methods: Patients with a definite diagnosis of ALS according to the Revised-El Escorial and Awaji criteria at any stage of the disease, who applied to the Electromyography EMG laboratory of the Neurology Clinic of Istanbul University Cerrahpaşa, Cerrahpaşa Medical Faculty, prospectively and cross-sectionally, were included in the study. The revised ALS functional rating scale ALSFRS-R was scored. Electrophysiological studies included routine nerve conduction studies, F responses and needle EMG. In radiological examinations, diffusion tractography imaging DTI maps were obtained in brain and cervical Magnetic Resonance Imaging MRI and diffusivity and fractional anisotropy FA values were compared. Results: The mean age of the 12 volunteer patients included in the study was 55.929.68 43-72, and consisted of 4 female and 8 male individuals. The mean ALSFRS-R score was 35.757.86 24-46. MRI was performed in 11 of the patients, spinal imaging could not be performed in one patient. The mean age of the 11 patients who were imaging was 56.49.8 years and the disease duration was 2.71.9 years. Low values of DTI-FA were found to be associated with poor respiratory and speech scores as assessed by linear regression analysis. Repeater F responses in the ulnar nerves were also associated with a high ALSFRS-R score. Conclusion: In our study, we observed that low values of DTI-FA were associated with poor respiratory and speech scores. Showing the correlation of low FA with a vital function such as respiration may indicate that this technique will be helpful in the prognosis and progression of the disease. The increase of repeater F responses in the ulnar nerves in those with high ALSFRS-R scores suggests that it is worth investigating whether ALS can be used in differentiating from other anterior horn diseases. The results of this study suggest that DTI-FA, which is an advanced radiological evaluation, and repeater F responses as an electrophysiological method may support early diagnosis in ALS.

 Purpose: The aim of this study is to show whether radiologically diffusion tractography imaging DTI and electrophysiologically F responses methods support clinical examination in Amyotrophic Lateral Sclerosis ALS. It is to determine the relationships between these two methods. Materials and Methods: Patients with a definite diagnosis of ALS according to the Revised-El Escorial and Awaji criteria at any stage of the disease, who applied to the Electromyography EMG laboratory of the Neurology Clinic of Istanbul University Cerrahpaşa, Cerrahpaşa Medical Faculty, prospectively and cross-sectionally, were included in the study. The revised ALS functional rating scale ALSFRS-R was scored. Electrophysiological studies included routine nerve conduction studies, F responses and needle EMG. In radiological examinations, diffusion tractography imaging DTI maps were obtained in brain and cervical Magnetic Resonance Imaging MRI and diffusivity and fractional anisotropy FA values were compared. Results: The mean age of the 12 volunteer patients included in the study was 55.929.68 43-72, and consisted of 4 female and 8 male individuals. The mean ALSFRS-R score was 35.757.86 24-46. MRI was performed in 11 of the patients, spinal imaging could not be performed in one patient. The mean age of the 11 patients who were imaging was 56.49.8 years and the disease duration was 2.71.9 years. Low values of DTI-FA were found to be associated with poor respiratory and speech scores as assessed by linear regression analysis. Repeater F responses in the ulnar nerves were also associated with a high ALSFRS-R score. Conclusion: In our study, we observed that low values of DTI-FA were associated with poor respiratory and speech scores. Showing the correlation of low FA with a vital function such as respiration may indicate that this technique will be helpful in the prognosis and progression of the disease. The increase of repeater F responses in the ulnar nerves in those with high ALSFRS-R scores suggests that it is worth investigating whether ALS can be used in differentiating from other anterior horn diseases. The results of this study suggest that DTI-FA, which is an advanced radiological evaluation, and repeater F responses as an electrophysiological method may support early diagnosis in ALS.

 Amaç: Bu çalışmanın amacı, Amiyotrofik Lateral Skleroz ALS hastalığında radyolojik olarak difüzyon traktografi görüntüleme DTG ve elektrofizyolojik olarak F yanıtlarının klinik muayeneyi destekleyip desteklemediğini göstermektir. Gereç ve Yöntem: İstanbul Üniversitesi Cerrahpaşa Cerrahpaşa Tıp Fakültesi Nöroloji Kliniği Elektromiyografi EMG laboratuvarına başvuran, hastalığın herhangi bir evresindeki Revize-El Escorial ve Awaji kriterlerine göre kesin ALS tanısı alan hastalar prospektif, kesitsel olarak çalışmaya alındı. Revize ALS fonksiyonel derecelendirme ölçeği ALSFRS-R uygulandı. Elektrofizyolojik incelemelerde rutin sinir iletim çalışmaları, F yanıtları ve iğne EMGsi incelendi. Radyolojik incelemelerde, Radyolojik incelemelerde beyin ve servikal manyetik rezonanas görüntülemede MRG difüzyon traktografi görüntüleme DTG haritaları elde edildi ve difüzyon ve fraksiyonel anizotropi FA değerleri karşılaştırıldı. Bulgular: Çalışmaya alınan 12 gönüllü hastanın yaş ortalaması 55.929.68 43-72 idi ve 4ü kadın, 8i erkek bireyden oluşmaktaydı. Ortalama ALSFRS-R puanı 35.757.86 24-46 idi. Hastaların 11ine MR görüntülemesi yapıldı, bir hastanın spinal görüntülemesi yapılamadı. Görüntüleme yapılan 11 hastanın ortalama yaş 56,49,8 ve hastalık süresi 2,71,9 yıldı. Düşük DTG-FA değerlerinin, lineer regresyon analizi ile değerlendirildiğinde kötü solunum ve konuşma skorları ile ilişkili olduğu bulundu. Ulnar sinirlerdeki tekrarlayan F yanıtları da yüksek bir ALSFRS skoru ile ilişkilendirildi. Sonuç: Çalışmamızda düşük DTG-FA değerlerinin kötü solunum ve konuşma skorları ile ilişkili olduğunu gözlemledik. Düşük FAnın solunum gibi hayati bir fonksiyonla ilişkisinin gösterilmesi, bu tekniğin hastalığın prognozunda ve ilerlemesinde yardımcı olacağına işaret edebilir. ALSFRS-R skoru yüksek olanlarda ulnar sinirlerde tekrarlayan F yanıtlarının artması ALSnin diğer ön boynuz hastalıklarından ayırıcı tanısında kullanılıp kullanılamayacağını düşündürmektedir. Bu çalışmanın sonuçları, ileri radyolojik bir değerlendirme olan DTG-FA ve elektrofizyolojik bir yöntem olarak tekrarlayan F yanıtlarının ALSde erken tanıyı destekleyebileceğini düşündürmektedir.

Makale detayları

Evaluation of the relationship between clinical findings and F responses and diffusion tensor tractography in patients with amyotrophic lateral sclerosis

Yazarlar:

Pınar Bekdik | Tuba Cerrahoğlu Şirin | Serdar Arslan | Nurten Uzun Adatepe

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 1, pp.208-215

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282249

pISSN:

2602-3032

Amyotrophic Lateral Sclerosis

F response

Diffusion Tensor Imaging

Fractional Anisotropy

Amiyotrofik Lateral Skleroz

F yanıtı

Difüzyon Tensor Görüntüleme

Fraksiyonel Anizotropi

Sayı

Makale detayları

Yazarlar: Pınar Bekdik | Tuba Cerrahoğlu Şirin | Serdar Arslan | Nurten Uzun Adatepe

Yayıncı: Cukurova University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Cukurova Medical Journal Vol.48 Issue 1, pp.208-215

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001282249

pISSN: 2602-3032

Sayı

Yazarlar:

Pınar Bekdik | Tuba Cerrahoğlu Şirin | Serdar Arslan | Nurten Uzun Adatepe

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 1, pp.208-215

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282249

pISSN:

2602-3032