Evaluation of Demographic, Hematological and Laboratory Findings of Patients with Childhood Brucellosis Admitted to a Single Center

Merve Kılıç Çil; Metin Çil

Makale detayları

Evaluation of Demographic, Hematological and Laboratory Findings of Patients with Childhood Brucellosis Admitted to a Single Center

Yazarlar:

Merve Kılıç Çil | Metin Çil

Yayıncı:

Mugla Sitki Kocman University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.10 Issue 2, pp.104-109

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001296751

pISSN:

2148-8118

Anahtar kelimeler:

Özet:

 Brucellosis, transmitted to humans from infected animals and their products, is a zoonotic infection still common in our country and worldwide. We aimed to evaluate the demographic characteristics, and hematological and laboratory abnormalities of pediatric brucellosis cases admitted to a single center. In this study, 47 pediatric patients who were followed up with the diagnosis of Brucellosis between June 2020-2021 were retrospectively analyzed. Of the 47 patients, 48.9 were male and 51.1 were female, mean age was 9.96  4.26 years. 48.9 of patients lived in rural areas, 78.7 of patients had a history of using raw milk. 44.7 had a similar disease history in the household. Five of 20 patients with muscle and joint pain had arthritis 10.6, the most commonly involved joint was the knee the and the most common abnormal physical examination finding was fever 12.8. Hematological involvement was observed in at least one series in 57.4 of patients. The most common hematological finding was anemia 46.8. Thrombocytopenia and leukopenia were detected in four patients 8.5. In all cases, agglutination tests were positive. The rate of blood culture positivity was 12.8. 21.3 of patients were hospitalized. Combined therapy was given to all patients. No treatment-related side effects were observed. While relapse was observed in 1 patient, no mortality was detected. Brucellosis still continues to be an important health problem, because its clinical findings are not specific, and complications are high. It should definitely be kept in mind in the differential diagnosis of cytopenia in patients living in endemic areas because of the presence of deterioration in hematological findings.

 Brucellosis, transmitted to humans from infected animals and their products, is a zoonotic infection still common in our country and worldwide. We aimed to evaluate the demographic characteristics, and hematological and laboratory abnormalities of pediatric brucellosis cases admitted to a single center. In this study, 47 pediatric patients who were followed up with the diagnosis of Brucellosis between June 2020-2021 were retrospectively analyzed. Of the 47 patients, 48.9 were male and 51.1 were female, mean age was 9.96  4.26 years. 48.9 of patients lived in rural areas, 78.7 of patients had a history of using raw milk. 44.7 had a similar disease history in the household. Five of 20 patients with muscle and joint pain had arthritis 10.6, the most commonly involved joint was the knee the and the most common abnormal physical examination finding was fever 12.8. Hematological involvement was observed in at least one series in 57.4 of patients. The most common hematological finding was anemia 46.8. Thrombocytopenia and leukopenia were detected in four patients 8.5. In all cases, agglutination tests were positive. The rate of blood culture positivity was 12.8. 21.3 of patients were hospitalized. Combined therapy was given to all patients. No treatment-related side effects were observed. While relapse was observed in 1 patient, no mortality was detected. Brucellosis still continues to be an important health problem, because its clinical findings are not specific, and complications are high. It should definitely be kept in mind in the differential diagnosis of cytopenia in patients living in endemic areas because of the presence of deterioration in hematological findings.

 Brucellosis, transmitted to humans from infected animals and their products, is a zoonotic infection still common in our country and worldwide. We aimed to evaluate the demographic characteristics, and hematological and laboratory abnormalities of pediatric brucellosis cases admitted to a single center. In this study, 47 pediatric patients who were followed up with the diagnosis of Brucellosis between June 2020-2021 were retrospectively analyzed. Of the 47 patients, 48.9 were male and 51.1 were female, mean age was 9.96  4.26 years. 48.9 of patients lived in rural areas, 78.7 of patients had a history of using raw milk. 44.7 had a similar disease history in the household. Five of 20 patients with muscle and joint pain had arthritis 10.6, the most commonly involved joint was the knee the and the most common abnormal physical examination finding was fever 12.8. Hematological involvement was observed in at least one series in 57.4 of patients. The most common hematological finding was anemia 46.8. Thrombocytopenia and leukopenia were detected in four patients 8.5. In all cases, agglutination tests were positive. The rate of blood culture positivity was 12.8. 21.3 of patients were hospitalized. Combined therapy was given to all patients. No treatment-related side effects were observed. While relapse was observed in 1 patient, no mortality was detected. Brucellosis still continues to be an important health problem, because its clinical findings are not specific, and complications are high. It should definitely be kept in mind in the differential diagnosis of cytopenia in patients living in endemic areas because of the presence of deterioration in hematological findings.

 Enfekte hayvanlardan ve ürünlerinden insanlara bulaşan bruselloz, ülkemizde ve tüm dünyada halen yaygın olarak görülen zoonotik bir enfeksiyondur. Çalışmamızda tek merkeze başvuran pediatrik bruselloz vakalarının demografik özellikleri, hematolojik ve laboratuvar anormalliklerinin değerlendirilmesi amaçlanmıştır. Bu çalışmada Haziran 2020 ile Haziran 2021 tarihleri arasında bruselloz nedeni ile takip edilen 47 çocuk hasta retrospektif olarak incelenmiştir. Çalışmamızdaki 47 hastanın 23 48.9ü erkek, 24 51.1ü kızdı ve yaş ortalaması 9.96  4.26 1.3-17.5 yaş idi. Hastaların 48.9u kırsalda yaşıyordu, 37 78.7sinde çiğ süt veya süt ürünü tüketim öyküsü vardı. Hastaların 44.7sinde ise hanede benzer hastalık öyküsü mevcuttu. Başvuru şikayetlerine bakıldığında; en sık başvuru şikayetleri ateş, kas-eklem ağrısı ve halsizlikti. Kas ve eklem ağrısı olan 20 hastadan 42.6 beş tanesinin artriti vardı 10.6, en sık tutulan eklem dizdi 6.4. En sık saptanan fizik muayene bulgusu ateş idi 12.8. Hastaların 57.4ünde en az bir seride hematolojik tutulum gözlendi. En yaygın hematolojik bulgu anemiydi 46.8. Dörder hastada trombositopeni ve lökopeni tespit edildi 8.5. Hastaların üçünde bisitopeni 6.4, birisinde ise pansitopeni gözlendi 2.1. Brucella aglütinasyon testleri olguların tamamında pozitifti. Kan kültürü pozitiflik oranı 12.8 idi. Hastaların 21.3ü hastaneye yatırılarak takip edildi. Tüm hastalara kombine tedavi verildi. Tedavi ilişkili yan etki gözlenmedi. Bir hastada relaps görülürken, mortalite saptanmadı. Bruselloz, klinik bulgularının özgül olmaması, komplikasyonlarının fazla olması ve geniş kitleleri etkileyebilmesi nedeniyle halen ülkemizde önemli bir sağlık sorunu olmaya devam etmektedir. Hematolojik bulgularda bozulma da görülebilmesi nedeniyle endemik bölgede yaşayan hastalarda sitopeninin ayırıcı tanısında bruselloz mutlaka akılda tutulmalıdır.

Makale detayları

Evaluation of Demographic, Hematological and Laboratory Findings of Patients with Childhood Brucellosis Admitted to a Single Center

Yazarlar:

Merve Kılıç Çil | Metin Çil

Yayıncı:

Mugla Sitki Kocman University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.10 Issue 2, pp.104-109

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001296751

pISSN:

2148-8118

Brucellosis

Children

Hematological Findings

CytopeniaBruselloz

Çocuk

Hematolojik Bulgular

Sitopeni

Sayı

Makale detayları

Yazarlar: Merve Kılıç Çil | Metin Çil

Yayıncı: Mugla Sitki Kocman University

Ana Başlıklar: İç Hastalıkları

Dergi: Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.10 Issue 2, pp.104-109

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001296751

pISSN: 2148-8118

Sayı

Yazarlar:

Merve Kılıç Çil | Metin Çil

Yayıncı:

Mugla Sitki Kocman University

Ana Başlıklar:

İç Hastalıkları

Dergi:

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi Vol.10 Issue 2, pp.104-109

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001296751

pISSN:

2148-8118