Biological activities of three Phlomis species

Nuraniye Eruygur; Damla Kırcı; Fatma Ayaz; Süleyman Doğu; Yavuz Bağcı

Makale detayları

Biological activities of three Phlomis species

Yazarlar:

Nuraniye Eruygur | Damla Kırcı | Fatma Ayaz | Süleyman Doğu | Yavuz Bağcı

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 2, pp.255-262

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346333

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The genus Phlomis, which belongs to the Lamiaceae family, comprises 100 species native to Turkey, Asia, Europe, and North Africa. As reported in many studies, Phlomis genus has unique therapeutic and aromatic properties. According to the data obtained from traditional uses, Phlomis species have a characteristic taste and so are traditionally consumed as herbal tea to treat diabetes, gastrointestinal disease as well as maintain overall health by protecting the liver, kidney, bone, and cardiovascular systems. In this present work, it was focused on the evaluation of the in-vitro enzyme inhibition α-glucosidase, α-amylase, acetylcholinesterase AChEbutyrylcholinesterase BuChE, and tyrosinase TYR and non-enzyme antioxidant activities TPC, TFC, DPPH, and ABTS radical scavenging assays, and Iron-chelating activity assay of the dichloromethane DCM and methanol extracts prepared from aerial parts of Phlomis nissolii, P. samia and P. sieheana with ultrasonic assisted method. All methanol extracts were rich in phenolic compounds and have high antioxidant activities. In the literature, there is no activity study related to the extracts of P. sieheana. The methanol extract of P. samia was the most active among other observed species. Especially the high tyrosinase enzyme inhibition activity of P. sieheana DCM extract may be promising for cosmetic product development.

 The genus Phlomis, which belongs to the Lamiaceae family, comprises 100 species native to Turkey, Asia, Europe, and North Africa. As reported in many studies, Phlomis genus has unique therapeutic and aromatic properties. According to the data obtained from traditional uses, Phlomis species have a characteristic taste and so are traditionally consumed as herbal tea to treat diabetes, gastrointestinal disease as well as maintain overall health by protecting the liver, kidney, bone, and cardiovascular systems. In this present work, it was focused on the evaluation of the in-vitro enzyme inhibition α-glucosidase, α-amylase, acetylcholinesterase AChEbutyrylcholinesterase BuChE, and tyrosinase TYR and non-enzyme antioxidant activities TPC, TFC, DPPH, and ABTS radical scavenging assays, and Iron-chelating activity assay of the dichloromethane DCM and methanol extracts prepared from aerial parts of Phlomis nissolii, P. samia and P. sieheana with ultrasonic assisted method. All methanol extracts were rich in phenolic compounds and have high antioxidant activities. In the literature, there is no activity study related to the extracts of P. sieheana. The methanol extract of P. samia was the most active among other observed species. Especially the high tyrosinase enzyme inhibition activity of P. sieheana DCM extract may be promising for cosmetic product development.

 The genus Phlomis, which belongs to the Lamiaceae family, comprises 100 species native to Turkey, Asia, Europe, and North Africa. As reported in many studies, Phlomis genus has unique therapeutic and aromatic properties. According to the data obtained from traditional uses, Phlomis species have a characteristic taste and so are traditionally consumed as herbal tea to treat diabetes, gastrointestinal disease as well as maintain overall health by protecting the liver, kidney, bone, and cardiovascular systems. In this present work, it was focused on the evaluation of the in-vitro enzyme inhibition α-glucosidase, α-amylase, acetylcholinesterase AChEbutyrylcholinesterase BuChE, and tyrosinase TYR and non-enzyme antioxidant activities TPC, TFC, DPPH, and ABTS radical scavenging assays, and Iron-chelating activity assay of the dichloromethane DCM and methanol extracts prepared from aerial parts of Phlomis nissolii, P. samia and P. sieheana with ultrasonic assisted method. All methanol extracts were rich in phenolic compounds and have high antioxidant activities. In the literature, there is no activity study related to the extracts of P. sieheana. The methanol extract of P. samia was the most active among other observed species. Especially the high tyrosinase enzyme inhibition activity of P. sieheana DCM extract may be promising for cosmetic product development.

 The genus Phlomis, which belongs to the Lamiaceae family, comprises 100 species native to Turkey, Asia, Europe, and North Africa. As reported in many studies, Phlomis genus has unique therapeutic and aromatic properties. According to the data obtained from traditional uses, Phlomis species have a characteristic taste and so are traditionally consumed as herbal tea to treat diabetes, gastrointestinal disease as well as maintain overall health by protecting the liver, kidney, bone, and cardiovascular systems. In this present work, it was focused on the evaluation of the in-vitro enzyme inhibition α-glucosidase, α-amylase, acetylcholinesterase AChEbutyrylcholinesterase BuChE, and tyrosinase TYR and non-enzyme antioxidant activities TPC, TFC, DPPH, and ABTS radical scavenging assays, and Iron-chelating activity assay of the dichloromethane DCM and methanol extracts prepared from aerial parts of Phlomis nissolii, P. samia and P. sieheana with ultrasonic assisted method. All methanol extracts were rich in phenolic compounds and have high antioxidant activities. In the literature, there is no activity study related to the extracts of P. sieheana. The methanol extract of P. samia was the most active among other observed species. Especially the high tyrosinase enzyme inhibition activity of P. sieheana DCM extract may be promising for cosmetic product development.

Makale detayları

Biological activities of three Phlomis species

Yazarlar:

Nuraniye Eruygur | Damla Kırcı | Fatma Ayaz | Süleyman Doğu | Yavuz Bağcı

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 2, pp.255-262

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346333

pISSN:

2630-6344

Phlomis nissolii;

P. samia

P. sieheana

antioxidant activity

enzyme inhibitory

Sayı

Makale detayları

Biological activities of three Phlomis species

Yazarlar: Nuraniye Eruygur | Damla Kırcı | Fatma Ayaz | Süleyman Doğu | Yavuz Bağcı

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy

Dergi: Journal of Research in Pharmacy Vol.26 Issue 2, pp.255-262

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346333

pISSN: 2630-6344

Phlomis nissolii;

P. samia

P. sieheana

antioxidant activity

enzyme inhibitory

Sayı

Yazarlar:

Nuraniye Eruygur | Damla Kırcı | Fatma Ayaz | Süleyman Doğu | Yavuz Bağcı

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 2, pp.255-262

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346333

pISSN:

2630-6344