TLR2 (-196 to -174 Ins/Del) and TLR3 (1377C>T) as biomarkers for nasopharyngeal cancer in Tunisia

Lamia MAKNI; Amira MESSADI; Sabrina ZIDI; Ezzedine GAZOUANI; Amel MEZLINI; Besma YACOUBI-LOUESLATI

Makale detayları

TLR2 (-196 to -174 Ins/Del) and TLR3 (1377C>T) as biomarkers for nasopharyngeal cancer in Tunisia

Yazarlar:

Lamia MAKNI | Amira MESSADI | Sabrina ZIDI | Ezzedine GAZOUANI | Amel MEZLINI | Besma YACOUBI-LOUESLATI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 4, pp.1216-1222

Belge Tipi:

Makale

Yayın Tarihi:

7/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751234

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: We evaluated the association of TLR2 (-196 to -174 Ins/Del) and TLR3 (1377 C>T) as potential risk factors for nasopharyngeal carcinoma (NPC) in Tunisians.   Material and methods: The study subjects comprised 137 NPC patients and 164 cancer-free control subjects. TLR2 genotyping was done by PCR and TLR3 genotyping was performed by PCR-RFLP.   Results: Minor allele frequency (MAF) and genotypes of TLR3 (1377 C>T) were comparable between NPC patients and controls. Significantly higher MAF and TLR2-containing Del allele genotypes of TLR2 (-196 to -174 Ins/Del) were seen in NPC patients compared to controls [OR (95% CI) = 2.10 (1.43-3.08), P < 0.001 and OR (95% CI) = 2.07 (1.27-3.37), P = 0.003]. In addition, higher increased NPC risk was associated with the TLR2-Del/Del genotype [OR (95% CI) = 2.74 (1.37-5.48), P = 0.004]. An increased frequency of the Del-T haplotype was seen in NPC cases compared to controls.   Conclusion: Our results demonstrate an increased risk of NPC with the TLR2-Del/Del genotype and Del-T TLR2 and TLR3 haplotype, suggesting their potential use as biomarkers to evaluate NPC risk in Tunisians.

Makale detayları

TLR2 (-196 to -174 Ins/Del) and TLR3 (1377C>T) as biomarkers for nasopharyngeal cancer in Tunisia

Yazarlar: Lamia MAKNI | Amira MESSADI | Sabrina ZIDI | Ezzedine GAZOUANI | Amel MEZLINI | Besma YACOUBI-LOUESLATI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 4, pp.1216-1222

Belge Tipi: Makale

Yayın Tarihi: 7/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751234

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Lamia MAKNI | Amira MESSADI | Sabrina ZIDI | Ezzedine GAZOUANI | Amel MEZLINI | Besma YACOUBI-LOUESLATI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 4, pp.1216-1222

Belge Tipi:

Makale

Yayın Tarihi:

7/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751234

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144