Comparison of brain volume measurements in methamphetamine use disorder with healthy individuals using volbrain method

Gülnihal Deniz; Nurgül Karakurt; Halil Özcan; Niyazi Acer

Makale detayları

Comparison of brain volume measurements in methamphetamine use disorder with healthy individuals using volbrain method

Yazarlar:

Gülnihal Deniz | Nurgül Karakurt | Halil Özcan | Niyazi Acer

Yayıncı:

Adıyaman University

Ana Başlıklar:

Merkezi Sinir Sistemi

Dergi:

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi Vol.9 Issue 3, pp.188-198

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001305475

pISSN:

2458-9179

Anahtar kelimeler:

Özet:

 Aim: This study aims to examine brain structures in individuals with methamphetamine use disorder MUD and to understand the possible effects of methamphetamine on these structures. Materials and Methods: The study was retrospectively evaluated in 21 MUD and 21 healthy controls. VolBrain segmentation method was used. Results: Grey Matter GM, Cortical GM, Cerebrum total, and GM volumes were found to be less and significantly higher in MUD compared to healthy controls p0.01. Accumbens, Basal Forebrain, Caudate, Pallidum, Putamen, and Parietal Lobe volumes were increased in MUD p0.01. Amygdala, Hippocampus, Ventral Diencephalone, Frontal Lobe, Posterior Orbital Gyrus, Precentral Gyrus, Temporal Lobe, Calcarine Cortex, Middle Occipital Gyrus, Superior Occipital Gyrus, Limbic Cortex volumes were significantly smaller in MUD compared to healthy controls. Conclusion: This study helped us better understand MUDs effects on brain structures. It also provided important information for developing effective strategies for treating and preventing MUD.

 Aim: This study aims to examine brain structures in individuals with methamphetamine use disorder MUD and to understand the possible effects of methamphetamine on these structures. Materials and Methods: The study was retrospectively evaluated in 21 MUD and 21 healthy controls. VolBrain segmentation method was used. Results: Grey Matter GM, Cortical GM, Cerebrum total, and GM volumes were found to be less and significantly higher in MUD compared to healthy controls p0.01. Accumbens, Basal Forebrain, Caudate, Pallidum, Putamen, and Parietal Lobe volumes were increased in MUD p0.01. Amygdala, Hippocampus, Ventral Diencephalone, Frontal Lobe, Posterior Orbital Gyrus, Precentral Gyrus, Temporal Lobe, Calcarine Cortex, Middle Occipital Gyrus, Superior Occipital Gyrus, Limbic Cortex volumes were significantly smaller in MUD compared to healthy controls. Conclusion: This study helped us better understand MUDs effects on brain structures. It also provided important information for developing effective strategies for treating and preventing MUD.

 Aim: This study aims to examine brain structures in individuals with methamphetamine use disorder MUD and to understand the possible effects of methamphetamine on these structures. Materials and Methods: The study was retrospectively evaluated in 21 MUD and 21 healthy controls. VolBrain segmentation method was used. Results: Grey Matter GM, Cortical GM, Cerebrum total, and GM volumes were found to be less and significantly higher in MUD compared to healthy controls p0.01. Accumbens, Basal Forebrain, Caudate, Pallidum, Putamen, and Parietal Lobe volumes were increased in MUD p0.01. Amygdala, Hippocampus, Ventral Diencephalone, Frontal Lobe, Posterior Orbital Gyrus, Precentral Gyrus, Temporal Lobe, Calcarine Cortex, Middle Occipital Gyrus, Superior Occipital Gyrus, Limbic Cortex volumes were significantly smaller in MUD compared to healthy controls. Conclusion: This study helped us better understand MUDs effects on brain structures. It also provided important information for developing effective strategies for treating and preventing MUD.

 Amaç: Bu çalışmanın amacı, metamfetamin kullanım bozukluğu MKB olan bireylerde beyin yapılarını incelemek ve metamfetaminin bu yapılar üzerindeki olası etkilerini anlamaktır. Gereç ve Yöntem: Çalışmada 21 MKB ve 21 sağlıklı kontrol retrospektif olarak değerlendirildi. VolBrain segmentasyon yöntemi kullanıldı. Bulgular: Substantia grisea SG, kortikal SG serebrum total ve SG hacimleri sağlıklı kontrol grubuna kıyasla daha az ve anlamlı bulunmuştur p0,01. Accumbens, pars basalis telencephali, lobus caudatus, globus pallidus, putamen ve lobus parietalis hacimleri MKBde artmıştır p0,01. Amygdala, hippocampus, ventral diensefalon, lobus frontalis, gyrus orbitalis posterior, gyrus precentralis, lobus temporalis, calcarine cortex, gyrus occipitalis medium, gyrus occipitalis superior, lobus limbicus hacimleri MKBde sağlıklı kontrollere kıyasla anlamlı derecede küçüktü. Sonuç: Bu çalışma, MKBnin beyin yapıları üzerindeki etkilerini daha iyi anlamamıza yardımcı oldu. Ayrıca, MKB tedavisi ve önlenmesi için etkili stratejiler geliştirmek için önemli bilgiler sağlamıştır.

Makale detayları

Comparison of brain volume measurements in methamphetamine use disorder with healthy individuals using volbrain method

Yazarlar:

Gülnihal Deniz | Nurgül Karakurt | Halil Özcan | Niyazi Acer

Yayıncı:

Adıyaman University

Ana Başlıklar:

Merkezi Sinir Sistemi

Dergi:

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi Vol.9 Issue 3, pp.188-198

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001305475

pISSN:

2458-9179

Methamphetamine

Brain

Grey matter

Basal forebrainMetamfetamin;

Beyin

Gri madde

Bazal ön beyin

Sayı

Makale detayları

Yazarlar: Gülnihal Deniz | Nurgül Karakurt | Halil Özcan | Niyazi Acer

Yayıncı: Adıyaman University

Ana Başlıklar: Merkezi Sinir Sistemi

Dergi: Adıyaman Üniversitesi Sağlık Bilimleri Dergisi Vol.9 Issue 3, pp.188-198

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001305475

pISSN: 2458-9179

Sayı

Yazarlar:

Gülnihal Deniz | Nurgül Karakurt | Halil Özcan | Niyazi Acer

Yayıncı:

Adıyaman University

Ana Başlıklar:

Merkezi Sinir Sistemi

Dergi:

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi Vol.9 Issue 3, pp.188-198

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001305475

pISSN:

2458-9179