Comparison of Maternal Platelets in Preeclampsia and Normotensive Pregnancies: An Ultrastructural Study

Elif ERDEM; Murat AKKUS; Selcuk TUNİK; Yusuf NERGİZ; Mehmet Siddik EVSEN; Mehmet Zeki TANER

Makale detayları

Comparison of Maternal Platelets in Preeclampsia and Normotensive Pregnancies: An Ultrastructural Study

Yazarlar:

Elif ERDEM | Murat AKKUS | Selcuk TUNİK | Yusuf NERGİZ | Mehmet Siddik EVSEN | Mehmet Zeki TANER

Yayıncı:

Veysi AKPOLAT

Dergi:

International Archives of Medical Research 2013 Vol.5 Issue 1, pp.9-15

Belge Tipi:

Makale

Yayın Tarihi:

5/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000470367

Sıklık:

İki Yıllık

pISSN:

2146-6033

Özet:

 

Background: Preeclampsia is characterized by hypertension and proteinuria occuring after the 20th week of
 gestation. The purpose of this study was to compare the ultrastructural changes occuring in platelets of
 preeclamptic and normotensive pregnant women.
 Method: Venous blood samples of whom 20 with preeclampsia and 20 of normotensive, for platelets
 extraction were firstly centrifuged. After prefixation and postfixation, was dehydrated at the increased
 alcohol degrees, left in infiltration and blocked. Then, semi-thin sections taken with ultramicrotome were
 stained with toludine blue. The assesment was made through light microscope following thin sections being
 taken and stained with contrast, platelets were examined ultrastructurally and their electron micrographs
 were taken.
 Results: In the preeclampsia group the number of alpha and dense granules decreased, to a great extent,
 and the structures of channel systems in tubular structure, were observed to be irregular.
 Conclusion: It is clearly seen that preeclampsia induces cellular damage in platelets and in case of
 aggravation in preeclampsia, it may cause significant changes in cell membranes of platelets and
 cytoplasmic organelles.

Makale detayları

Comparison of Maternal Platelets in Preeclampsia and Normotensive Pregnancies: An Ultrastructural Study

Yazarlar: Elif ERDEM | Murat AKKUS | Selcuk TUNİK | Yusuf NERGİZ | Mehmet Siddik EVSEN | Mehmet Zeki TANER

Yayıncı: Veysi AKPOLAT

Dergi: International Archives of Medical Research 2013 Vol.5 Issue 1, pp.9-15

Belge Tipi: Makale

Yayın Tarihi: 5/2013

Belge Dili: Türkçe

Document ID (Org No.): 2000470367

Sıklık: İki Yıllık

pISSN: 2146-6033

Sayı

Yazarlar:

Elif ERDEM | Murat AKKUS | Selcuk TUNİK | Yusuf NERGİZ | Mehmet Siddik EVSEN | Mehmet Zeki TANER

Yayıncı:

Veysi AKPOLAT

Dergi:

International Archives of Medical Research 2013 Vol.5 Issue 1, pp.9-15

Belge Tipi:

Makale

Yayın Tarihi:

5/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000470367

Sıklık:

İki Yıllık

pISSN:

2146-6033