Synthesis and antioxidant activity of benzo[a]pyrano[2,3- c] phenazine derivative compound via one-pot multicomponent reaction

Agus Rimus Liandi

Makale detayları

Synthesis and antioxidant activity of benzo[a]pyrano[2,3- c] phenazine derivative compound via one-pot multicomponent reaction

Yazarlar:

Agus Rimus Liandi

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 4, pp.954-961

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347287

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Phenazine derivative compounds are of concern because of their extraordinary activities in medicine. The aim of this study is to synthesize the derivative of benzoapyrano2,3-c phenazine compound based on lawsone with caffeine catalyst using the one-pot multicomponent reaction method and test its antioxidant activity. The formation of the target compound was evaluated for functional group vibration, maximum wavelength, and molecular weight by FTIR, UV-Vis Spectrophotometer, and LCMS, which showed the characteristics of the benzoapyrano2,3-c phenazine compound. The synthesized compound was 3-amino-2-cyano-1-2-hydroxyl-phenyl-1H-benzoapyrano2,3-c phenazine with the molecular formula C26H16N4O2. At the optimum condition of the reaction, the use of caffeine catalyst was able to give a product yield of 67.2. The potential of the synthesized compound as an antioxidant could be classified as a good antioxidant with an IC50 value of 14.26 ppm.

 Phenazine derivative compounds are of concern because of their extraordinary activities in medicine. The aim of this study is to synthesize the derivative of benzoapyrano2,3-c phenazine compound based on lawsone with caffeine catalyst using the one-pot multicomponent reaction method and test its antioxidant activity. The formation of the target compound was evaluated for functional group vibration, maximum wavelength, and molecular weight by FTIR, UV-Vis Spectrophotometer, and LCMS, which showed the characteristics of the benzoapyrano2,3-c phenazine compound. The synthesized compound was 3-amino-2-cyano-1-2-hydroxyl-phenyl-1H-benzoapyrano2,3-c phenazine with the molecular formula C26H16N4O2. At the optimum condition of the reaction, the use of caffeine catalyst was able to give a product yield of 67.2. The potential of the synthesized compound as an antioxidant could be classified as a good antioxidant with an IC50 value of 14.26 ppm.

 Phenazine derivative compounds are of concern because of their extraordinary activities in medicine. The aim of this study is to synthesize the derivative of benzoapyrano2,3-c phenazine compound based on lawsone with caffeine catalyst using the one-pot multicomponent reaction method and test its antioxidant activity. The formation of the target compound was evaluated for functional group vibration, maximum wavelength, and molecular weight by FTIR, UV-Vis Spectrophotometer, and LCMS, which showed the characteristics of the benzoapyrano2,3-c phenazine compound. The synthesized compound was 3-amino-2-cyano-1-2-hydroxyl-phenyl-1H-benzoapyrano2,3-c phenazine with the molecular formula C26H16N4O2. At the optimum condition of the reaction, the use of caffeine catalyst was able to give a product yield of 67.2. The potential of the synthesized compound as an antioxidant could be classified as a good antioxidant with an IC50 value of 14.26 ppm.

 Phenazine derivative compounds are of concern because of their extraordinary activities in medicine. The aim of this study is to synthesize the derivative of benzoapyrano2,3-c phenazine compound based on lawsone with caffeine catalyst using the one-pot multicomponent reaction method and test its antioxidant activity. The formation of the target compound was evaluated for functional group vibration, maximum wavelength, and molecular weight by FTIR, UV-Vis Spectrophotometer, and LCMS, which showed the characteristics of the benzoapyrano2,3-c phenazine compound. The synthesized compound was 3-amino-2-cyano-1-2-hydroxyl-phenyl-1H-benzoapyrano2,3-c phenazine with the molecular formula C26H16N4O2. At the optimum condition of the reaction, the use of caffeine catalyst was able to give a product yield of 67.2. The potential of the synthesized compound as an antioxidant could be classified as a good antioxidant with an IC50 value of 14.26 ppm.

Makale detayları

Synthesis and antioxidant activity of benzo[a]pyrano[2,3- c] phenazine derivative compound via one-pot multicomponent reaction

Yazarlar:

Agus Rimus Liandi

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 4, pp.954-961

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347287

pISSN:

2630-6344

Benzo[a]pyrano[2

3-c] phenazine

lawsone

one-pot multicomponent reaction

antioxidant

caffeine catalyst

Sayı

Makale detayları

Synthesis and antioxidant activity of benzo[a]pyrano[2,3- c] phenazine derivative compound via one-pot multicomponent reaction

Yazarlar: Agus Rimus Liandi

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Chemistry

Dergi: Journal of Research in Pharmacy Vol.26 Issue 4, pp.954-961

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347287

pISSN: 2630-6344

Benzo[a]pyrano[2

3-c] phenazine

lawsone

one-pot multicomponent reaction

antioxidant

caffeine catalyst

Sayı

Yazarlar:

Agus Rimus Liandi

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 4, pp.954-961

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347287

pISSN:

2630-6344