Histopathological and Antioxidant Effects of Bromelain on Kidney Tissue of Tyloxapol-Induced Hyperlipidemic Rats

Ayşe Nurseli Sulumer; Esra Palabıyık; Bahri Avcı; Handan Uğuz; Hakan Aşkın

Makale detayları

Histopathological and Antioxidant Effects of Bromelain on Kidney Tissue of Tyloxapol-Induced Hyperlipidemic Rats

Yazarlar:

Ayşe Nurseli Sulumer | Esra Palabıyık | Bahri Avcı | Handan Uğuz | Hakan Aşkın

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Enzimler | Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.29 Issue 2, pp.413-422

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326190

pISSN:

1300-5413

Anahtar kelimeler:

Özet:

 This study was designed to investigate the nephroprotective effect of Bromelain against oxidative stress induced by Tyloxopol-induced hyperlipidemia in rats. Rats n6 were divided into three groups. I: Control C Group: No treatment was given and only distilled water was given; II: Tyloxapol TX Group: Group receiving Tyloxapol 400 mgkg, i.p; III: Tyloxapol  Bromelain TXBR Group: Group receiving Tyloxapol 400 mgkg, i.p. and group receiving Bromelain 250 mgkg, o.d. for 18 days. As a result of Tyloxapol administration, oxidative stress parameters SOD and CAT levels decreased, while MDA levels increased. In addition, histopathologic variations were detected in kidney sections. On the other hand, lipid peroxidation decreased and most of the studied parameters improved with combined administration TXBR group. According to the results obtained, bromelain may be a potent and alternative agent with protective effect for further studies.

 This study was designed to investigate the nephroprotective effect of Bromelain against oxidative stress induced by Tyloxopol-induced hyperlipidemia in rats. Rats n6 were divided into three groups. I: Control C Group: No treatment was given and only distilled water was given; II: Tyloxapol TX Group: Group receiving Tyloxapol 400 mgkg, i.p; III: Tyloxapol  Bromelain TXBR Group: Group receiving Tyloxapol 400 mgkg, i.p. and group receiving Bromelain 250 mgkg, o.d. for 18 days. As a result of Tyloxapol administration, oxidative stress parameters SOD and CAT levels decreased, while MDA levels increased. In addition, histopathologic variations were detected in kidney sections. On the other hand, lipid peroxidation decreased and most of the studied parameters improved with combined administration TXBR group. According to the results obtained, bromelain may be a potent and alternative agent with protective effect for further studies.

 This study was designed to investigate the nephroprotective effect of Bromelain against oxidative stress induced by Tyloxopol-induced hyperlipidemia in rats. Rats n6 were divided into three groups. I: Control C Group: No treatment was given and only distilled water was given; II: Tyloxapol TX Group: Group receiving Tyloxapol 400 mgkg, i.p; III: Tyloxapol  Bromelain TXBR Group: Group receiving Tyloxapol 400 mgkg, i.p. and group receiving Bromelain 250 mgkg, o.d. for 18 days. As a result of Tyloxapol administration, oxidative stress parameters SOD and CAT levels decreased, while MDA levels increased. In addition, histopathologic variations were detected in kidney sections. On the other hand, lipid peroxidation decreased and most of the studied parameters improved with combined administration TXBR group. According to the results obtained, bromelain may be a potent and alternative agent with protective effect for further studies.

 Bu çalışma, ratlarda Tyloxopol ile indüklenen hiperlipidemi neticesinde oluşan oksidatif strese karşı Bromelainin nefroprotektif etkisinin incelenmesi için tasarlandı. Ratlar n6 üç grup altında sınıflandırıldı. I: Kontrol C Grubu: Herhangi bir uygulama yapılmayan ve sadece distile su verilen grup; II: Tyloxapol TX Grup: Tylaxopol 400 mgkg, i.p alan grup; III: Tyloxapol  Bromelain TXBR Grup: Tylaxopol 400 mgkg, i.p alan ve 18 gün Bromelain 250 mgkg, o.d. alan grup. Tyloxapol uygulaması neticesinde oksidatif stres parametrelerinden SOD ve CAT seviyelerinde azalma meydana gelirken MDA seviyelerinde artış görüldü. Buna ek olarak böbrek kesitlerinde histopatolojik varyasyonlar tespit edildi. Bunun aksine çalışmada, kombine uygulama ile TXBR grubu lipid peroksidasyonu azaldı ve çalışılan parametrelerin çoğunda iyileşme görüldü. Elde edilen sonuçlara göre bromelainin daha sonraki çalışmalar için koruyucu etkiye sahip güçlü ve alternatif bir ajan olabileceği düşünülmektedir.

Makale detayları

Histopathological and Antioxidant Effects of Bromelain on Kidney Tissue of Tyloxapol-Induced Hyperlipidemic Rats

Yazarlar:

Ayşe Nurseli Sulumer | Esra Palabıyık | Bahri Avcı | Handan Uğuz | Hakan Aşkın

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Enzimler | Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.29 Issue 2, pp.413-422

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326190

pISSN:

1300-5413

Bromelain

Histopathology

Hyperlipidemia

Kidney

Oxidative stress

TyloxapolBöbrek

Bromelain

Hiperlipidemi

Histopatoloji

Oksidatif stres

Tyloxapol

Sayı

Makale detayları

Yazarlar: Ayşe Nurseli Sulumer | Esra Palabıyık | Bahri Avcı | Handan Uğuz | Hakan Aşkın

Yayıncı: Van Yuzuncu Yıl University

Ana Başlıklar: Enzimler | Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi: Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.29 Issue 2, pp.413-422

Belge Tipi: Makale

Yayın Tarihi: 8/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001326190

pISSN: 1300-5413

Sayı

Yazarlar:

Ayşe Nurseli Sulumer | Esra Palabıyık | Bahri Avcı | Handan Uğuz | Hakan Aşkın

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Enzimler | Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.29 Issue 2, pp.413-422

Belge Tipi:

Makale

Yayın Tarihi:

8/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326190

pISSN:

1300-5413