Association of neutrophil/lymphocyte ratio with the degree of  interstitial lung disease in systemic sclerosis

Nurhan ATİLLA; Gözde Yildirim ÇETİN; Ayşe BALKARLI

Makale detayları

Association of neutrophil/lymphocyte ratio with the degree of interstitial lung disease in systemic sclerosis

Yazarlar:

Nurhan ATİLLA | Gözde Yildirim ÇETİN | Ayşe BALKARLI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 6, pp.1871-1874

Belge Tipi:

Makale

Yayın Tarihi:

11/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000751744

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Determining the severity of systemic sclerosis related interstitial lung disease (SSc-ILD) is based on clinical and radiological findings, inflammation marker levels, and carbon monoxide diffusing capacity of the lung (DLCO). Recently studies are ongoing for objective and easy markers. Neutrophil/lymphocyte ratio (NLR) is shown to be a good marker for inflammation in recent clinical trials. In this study, we aimed to identify the possible relationship between NLR and carbon monoxide transfer coefficient (KCO) of SSc-ILD patients.  Materials and methods: Fifty-nine patients with systemic sclerosis (SSc) were enrolled in the study. We used high-resolution computed tomography for diagnosis and used DLCO to evaluate degree of lung involvement. Complete blood cell counts and acute phase reactants were included as laboratory assessments.   Results: NLR values were significantly higher in the SSc-ILD group (3.66 ± 1.32 vs. 2.85 ± 1.12, P = 0.01) and correlated negatively with KCO. The NLR cut-off value was 3.21, its sensitivity was 81%, and its specificity was 81%.  Conclusion: NLR level may serve as a marker of lung involvement in the presence of ILD in patients with SSc.

Makale detayları

Association of neutrophil/lymphocyte ratio with the degree of interstitial lung disease in systemic sclerosis

Yazarlar: Nurhan ATİLLA | Gözde Yildirim ÇETİN | Ayşe BALKARLI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2016 Vol.46 Issue 6, pp.1871-1874

Belge Tipi: Makale

Yayın Tarihi: 11/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000751744

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Nurhan ATİLLA | Gözde Yildirim ÇETİN | Ayşe BALKARLI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 6, pp.1871-1874

Belge Tipi:

Makale

Yayın Tarihi:

11/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000751744

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144