The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats

Ayhan TANYELİ; Fazile Nur EKİNCİ AKDEMİR; Ersen ERASLAN; Mustafa Can GÜLER; Saime ÖZBEK ŞEBİN; Selim COMAKLI; İlhami GÜLÇİN

doi:https://doi.org/10.33808/clinexphealthsci.864015

Makale detayları

The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats

Yazarlar:

Ayhan TANYELİ | Fazile Nur EKİNCİ AKDEMİR | Ersen ERASLAN | Mustafa Can GÜLER | Saime ÖZBEK ŞEBİN | Selim COMAKLI | İlhami GÜLÇİN

Yayıncı:

Marmara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Clinical and Experimental Health Sciences 2022 Vol.12 Issue 1, pp.134-140

Belge Tipi:

Makale

Yayın Tarihi:

3/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000906620

Sıklık:

Aylık

eISSN:

2459-1459

DOI:

https://doi.org/10.33808/clinexphealthsci.864015

Özet:

 

Objectives: In this study, we investigated the possible useful effectiveness of Sinapic acid on rat kidney and lung tissues in an experimental cecal ligation puncture (CLP) model.
Methods: CLP model was created for the rats in the CLP group. 20 mg/kg of Sinapic acid was given in the CLP-Sinapic acid group. At the end of the experiment, lung and kidney tissues were collected and biochemical analyzes were evaluated.
Results: For the lung and kidney tissue samples; antioxidant levels decreased, and oxidant levels increased in the CLP group. When the immunohistochemical parameters were evaluated, IL-1β, caspase-3, and TNF-α immunopositivity were severe levels in CLP group. But immunopositivity of these parameters have been observed as attenuated in CLP-Sinapic acid group compared to CLP group.
Conclusion: The results of our study showed that Sinapic acid has useful effectiveness on the sepsis model caused by CLP in the lung and kidney tissues.

Makale detayları

The Possible Useful Effectiveness of Sinapic Acid Sepsis-Induced Secondary Organ Damage in Rats

Yazarlar: Ayhan TANYELİ | Fazile Nur EKİNCİ AKDEMİR | Ersen ERASLAN | Mustafa Can GÜLER | Saime ÖZBEK ŞEBİN | Selim COMAKLI | İlhami GÜLÇİN

Yayıncı: Marmara University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Clinical and Experimental Health Sciences 2022 Vol.12 Issue 1, pp.134-140

Belge Tipi: Makale

Yayın Tarihi: 3/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000906620

Sıklık: Aylık

eISSN: 2459-1459

DOI: https://doi.org/10.33808/clinexphealthsci.864015

Sayı

Yazarlar:

Ayhan TANYELİ | Fazile Nur EKİNCİ AKDEMİR | Ersen ERASLAN | Mustafa Can GÜLER | Saime ÖZBEK ŞEBİN | Selim COMAKLI | İlhami GÜLÇİN

Yayıncı:

Marmara University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Clinical and Experimental Health Sciences 2022 Vol.12 Issue 1, pp.134-140

Belge Tipi:

Makale

Yayın Tarihi:

3/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000906620

Sıklık:

Aylık

eISSN:

2459-1459

DOI:

https://doi.org/10.33808/clinexphealthsci.864015