The effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid(NCX 4016) on mice models of endotoxic and septic shock

Nadir ULU; Alper Bektaş İSKİT; Cenk SÖKMENSÜER; Mustafa Oğuz GÜÇ

doi:https://doi.org/10.3906/sag-1402-82

Makale detayları

The effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid(NCX 4016) on mice models of endotoxic and septic shock

Yazarlar:

Nadir ULU | Alper Bektaş İSKİT | Cenk SÖKMENSÜER | Mustafa Oğuz GÜÇ

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 4, pp.812-819

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000752558

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1402-82

Anahtar kelimeler:

Özet:

 

Background/aim: Nitric oxide-donating nonsteroidal antiinflammatory drugs (NO-NSAIDs) are a promising new class of antiinflammatory agents, which are obtained by adding NO-donating moieties to the existing conventional NSAID molecules. The aim   of this study was to investigate the effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid (NCX 4016) on cecal ligation   and puncture (CLP) and endotoxin-induced septic shock (LPS) models in mice.   Materials and methods: Overall survival and spleen and liver weights were monitored in LPS and CLP models. Histopathological examinations of liver and spleen were performed at the end of the experimental protocols.  Results: NCX 4016 was able to reverse the increased spleen weight in CLP-operated animals, whereas aspirin or flurbiprofen did not. Similar to the results of the CLP model, none of the drugs modified the survival rates in the LPS model. Flurbiprofen in particular produced significant histopathological damage in spleens and livers, which was less significant with aspirin. NCX 4016 did not cause   any liver damage.   Conclusion: NCX 4016 has the potential to be used in septic states, while special attention has to be paid to the effects of aspirin and flurbiprofen on the liver and spleen.

 

Background/aim: Nitric oxide-donating nonsteroidal antiinflammatory drugs (NO-NSAIDs) are a promising new class of antiinflammatory agents, which are obtained by adding NO-donating moieties to the existing conventional NSAID molecules. The aim   of this study was to investigate the effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid (NCX 4016) on cecal ligation   and puncture (CLP) and endotoxin-induced septic shock (LPS) models in mice.   Materials and methods: Overall survival and spleen and liver weights were monitored in LPS and CLP models. Histopathological examinations of liver and spleen were performed at the end of the experimental protocols.  Results: NCX 4016 was able to reverse the increased spleen weight in CLP-operated animals, whereas aspirin or flurbiprofen did not. Similar to the results of the CLP model, none of the drugs modified the survival rates in the LPS model. Flurbiprofen in particular produced significant histopathological damage in spleens and livers, which was less significant with aspirin. NCX 4016 did not cause   any liver damage.   Conclusion: NCX 4016 has the potential to be used in septic states, while special attention has to be paid to the effects of aspirin and flurbiprofen on the liver and spleen.

Makale detayları

The effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid(NCX 4016) on mice models of endotoxic and septic shock

Yazarlar:

Nadir ULU | Alper Bektaş İSKİT | Cenk SÖKMENSÜER | Mustafa Oğuz GÜÇ

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 4, pp.812-819

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000752558

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1402-82

Aspirin

flurbiprofen

NCX 4016

septic shock

cecal ligation and puncture

hepatotoxicity

Sayı

Makale detayları

The effects of aspirin, flurbiprofen, and NO-donating acetylsalicylic acid(NCX 4016) on mice models of endotoxic and septic shock

Yazarlar: Nadir ULU | Alper Bektaş İSKİT | Cenk SÖKMENSÜER | Mustafa Oğuz GÜÇ

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2015 Vol.45 Issue 4, pp.812-819

Belge Tipi: Makale

Yayın Tarihi: 8/2015

Belge Dili: İngilizce

Document ID (Org No.): 2000752558

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

DOI: https://doi.org/10.3906/sag-1402-82

Aspirin

flurbiprofen

NCX 4016

septic shock

cecal ligation and puncture

hepatotoxicity

Sayı

Yazarlar:

Nadir ULU | Alper Bektaş İSKİT | Cenk SÖKMENSÜER | Mustafa Oğuz GÜÇ

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 4, pp.812-819

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

İngilizce

Document ID (Org No.):

2000752558

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1402-82