Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

HACI AHMET BİRCAN; MÜNİRE ÇAKIR; İLKAY YILMAZER KAPULU; RECEP SÜTCÜ; SELÇUK KAYA; ÖNDER ÖZTÜRK

Makale detayları

Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Yazarlar:

HACI AHMET BİRCAN | MÜNİRE ÇAKIR | İLKAY YILMAZER KAPULU | RECEP SÜTCÜ | SELÇUK KAYA | ÖNDER ÖZTÜRK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.593-599

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752679

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Background/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP).   Materials and methods: Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre- and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography.   Results: MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P 3 days (P = 0.004) and was correlated with oxygenation and PSI scores. Posttreatment serum levels of MMP-9 and TIMP-1 were decreased after antibiotics (P = 0.0001 and P = 0.017, respectively).  Conclusion: Although MMP-2, MMP-9, and TIMP-1 correlate with many poor prognostic factors, more studies are required to prove their possible role in predicting the severity of CAP.

 

Background/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP).   Materials and methods: Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre- and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography.   Results: MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P 3 days (P = 0.004) and was correlated with oxygenation and PSI scores. Posttreatment serum levels of MMP-9 and TIMP-1 were decreased after antibiotics (P = 0.0001 and P = 0.017, respectively).  Conclusion: Although MMP-2, MMP-9, and TIMP-1 correlate with many poor prognostic factors, more studies are required to prove their possible role in predicting the severity of CAP.

Makale detayları

Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Yazarlar:

HACI AHMET BİRCAN | MÜNİRE ÇAKIR | İLKAY YILMAZER KAPULU | RECEP SÜTCÜ | SELÇUK KAYA | ÖNDER ÖZTÜRK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.593-599

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752679

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Matrix metalloproteinases

matrix metalloproteinase inhibitors

pneumonia

severity of illness index

Sayı

Makale detayları

Elevated serum matrix metalloproteinase-2 and -9 and their correlationswith severity of disease in patients with community-acquired pneumonia

Yazarlar: HACI AHMET BİRCAN | MÜNİRE ÇAKIR | İLKAY YILMAZER KAPULU | RECEP SÜTCÜ | SELÇUK KAYA | ÖNDER ÖZTÜRK

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.593-599

Belge Tipi: Makale

Yayın Tarihi: 8/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000752679

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Matrix metalloproteinases

matrix metalloproteinase inhibitors

pneumonia

severity of illness index

Sayı

Yazarlar:

HACI AHMET BİRCAN | MÜNİRE ÇAKIR | İLKAY YILMAZER KAPULU | RECEP SÜTCÜ | SELÇUK KAYA | ÖNDER ÖZTÜRK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.593-599

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752679

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144