The Controversial Role of Serum Uric Acid in Cardiovascular Diseases

Alexander E BEREZİN

doi:https://doi.org/10.5455/umj.20170608022350

Makale detayları

The Controversial Role of Serum Uric Acid in Cardiovascular Diseases

Yazarlar:

Alexander E BEREZİN

Yayıncı:

Kemal Türker ULUTAŞ

Dergi:

The Ulutas Medical Journal 2017 Vol.3 Issue 3, pp.54-56

Belge Tipi:

Makale

Yayın Tarihi:

6/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000802845

Sıklık:

Üç Aylık

eISSN:

2149-388X

pISSN:

2149-0430

DOI:

https://doi.org/10.5455/umj.20170608022350

Özet:

 

Previous clinical, observation and epidemiologic studies have demonstrated strong association between serum uric acid  SUA  and cardiovascular disease  hypertension, heart failure, asymptomatic atherosclerosis , metabolic states  abdominal obesity, diabetes mellitus, metabolic syndrome, insulin resistance  and kidney disease. There is a large body of evidence regarding the role of SUA as predictor of CV events and CV mortality in general population and individuals with established CV disease and metabolic diseases. However, SUA may exhibit protective effects on endothelium and vasculature as well as attenuate endogenous repair system through mobbing and differentiation of cell precursors. Although SUA lowering drugs are widely used in patients with symptomatic hyperuricemia and gout beyond their etiologies, there is no agreement of SUA below target level 6.0 mg/dL in asymptomatic individuals with kidney injury and CV disease and data of ones are sufficiently limited. The short communication is depicted on the controversial role of SUA as primary cell toxicity agent and secondary cell protector against hypoxia, ischemia and apoptosis.

Makale detayları

The Controversial Role of Serum Uric Acid in Cardiovascular Diseases

Yazarlar: Alexander E BEREZİN

Yayıncı: Kemal Türker ULUTAŞ

Dergi: The Ulutas Medical Journal 2017 Vol.3 Issue 3, pp.54-56

Belge Tipi: Makale

Yayın Tarihi: 6/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000802845

Sıklık: Üç Aylık

eISSN: 2149-388X

pISSN: 2149-0430

DOI: https://doi.org/10.5455/umj.20170608022350

Sayı

Yazarlar:

Alexander E BEREZİN

Yayıncı:

Kemal Türker ULUTAŞ

Dergi:

The Ulutas Medical Journal 2017 Vol.3 Issue 3, pp.54-56

Belge Tipi:

Makale

Yayın Tarihi:

6/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000802845

Sıklık:

Üç Aylık

eISSN:

2149-388X

pISSN:

2149-0430

DOI:

https://doi.org/10.5455/umj.20170608022350