DEVELOPMENT AND IN VITRO EVALUATION OF OLEUM ROSMARINI BASED TOPICAL EMULGEL FORMULATION FOR RHEUMATIC DISEASE

Tilbe Çevikelli; Nurdan Tezcan; Umay Merve Güven Bölgen; Serpil Demirci Kayıran

Makale detayları

DEVELOPMENT AND IN VITRO EVALUATION OF OLEUM ROSMARINI BASED TOPICAL EMULGEL FORMULATION FOR RHEUMATIC DISEASE

Yazarlar:

Tilbe Çevikelli | Nurdan Tezcan | Umay Merve Güven Bölgen | Serpil Demirci Kayıran

Yayıncı:

Ankara University

Ana Başlıklar:

Farmasotik Botanik | İlaç Dağıtım Teknolojileri

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.91-102

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001333046

pISSN:

1015-3918

Anahtar kelimeler:

Özet:

 Objective: In this study, it was aimed to develop a topical emulgel formulation from ow type emulsions containing Oleum rosmarini, to be used in the treatment of rheumatoid arthritis. Material and Method: Carbopol 996 and HPMC were used as the water phase and Oleum rosmarini was used as oil phase in the emulsion combinations containing oil, surfactant, copolymer and plasticizer at different rates over different polymer concentrations, to select the appropriate formulation with in vitro formulation studies. Organoleptic controls of the selected formulations were made and characterizations were made in terms of pH, texture profile analysis, rheology evaluation and thermodynamic stability. Result and Discussion: The pH value of the optimized formulations was in the range of 5.5-6.5. The formulations were obtained homogeneously, and no phase separation was observed. It has been observed that the emulgels provide suitable viscosity, flow properties, mechanical properties and have high stability for topical application.

 Objective: In this study, it was aimed to develop a topical emulgel formulation from ow type emulsions containing Oleum rosmarini, to be used in the treatment of rheumatoid arthritis. Material and Method: Carbopol 996 and HPMC were used as the water phase and Oleum rosmarini was used as oil phase in the emulsion combinations containing oil, surfactant, copolymer and plasticizer at different rates over different polymer concentrations, to select the appropriate formulation with in vitro formulation studies. Organoleptic controls of the selected formulations were made and characterizations were made in terms of pH, texture profile analysis, rheology evaluation and thermodynamic stability. Result and Discussion: The pH value of the optimized formulations was in the range of 5.5-6.5. The formulations were obtained homogeneously, and no phase separation was observed. It has been observed that the emulgels provide suitable viscosity, flow properties, mechanical properties and have high stability for topical application.

 Objective: In this study, it was aimed to develop a topical emulgel formulation from ow type emulsions containing Oleum rosmarini, to be used in the treatment of rheumatoid arthritis. Material and Method: Carbopol 996 and HPMC were used as the water phase and Oleum rosmarini was used as oil phase in the emulsion combinations containing oil, surfactant, copolymer and plasticizer at different rates over different polymer concentrations, to select the appropriate formulation with in vitro formulation studies. Organoleptic controls of the selected formulations were made and characterizations were made in terms of pH, texture profile analysis, rheology evaluation and thermodynamic stability. Result and Discussion: The pH value of the optimized formulations was in the range of 5.5-6.5. The formulations were obtained homogeneously, and no phase separation was observed. It has been observed that the emulgels provide suitable viscosity, flow properties, mechanical properties and have high stability for topical application.

 Amaç: Bu çalışmada romatoid artrit tedavisinde kullanılmak üzere Oleum rosmarini içeren ys tipi emülsiyonlardan topikal bir emüljel formülasyonunun geliştirilmesi ve in vitro karakterizasyonu amaçlanmıştır. Gereç ve Yöntem: In vitro formülasyon çalışmaları ile uygun formülasyonun seçilmesi amacıyla farklı polimer konsantrasyonlarında farklı oranlarda yağ, yüzey aktif madde, kopolimer ve plastizer içeren emülsiyon kombinasyonlarında su fazı olarak Carbopol 996 ve HPMC, yağ fazı olarak Oleum rosmarini kullanılmıştır. Seçilen formülasyonların organoleptik kontrolleri yapılmış ve pH, tekstür profili analizi, reoloji değerlendirmesi ve termodinamik stabilite açısından karakterizasyonları gerçekleştirilmiştir. Sonuç ve Tartışma: Optimize edilen krem formülasyonların pH değeri 5.5-6.5 aralığında olup, formülasyonlar homojen bir şekilde elde edilmiş ve herhangi bir faz ayrımı gözlenmemiştir. Emüljellerin topikal uygulama için uygun viskozite, akış özellikleri, mekanik özellikler gösterdiği ve yüksek termodinamik stabiliteye sahip olduğu belirlenmiştir.

Makale detayları

DEVELOPMENT AND IN VITRO EVALUATION OF OLEUM ROSMARINI BASED TOPICAL EMULGEL FORMULATION FOR RHEUMATIC DISEASE

Yazarlar:

Tilbe Çevikelli | Nurdan Tezcan | Umay Merve Güven Bölgen | Serpil Demirci Kayıran

Yayıncı:

Ankara University

Ana Başlıklar:

Farmasotik Botanik | İlaç Dağıtım Teknolojileri

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.91-102

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001333046

pISSN:

1015-3918

Essential oil

rheumatoid arthritis

Rosmarinus officinalis

topical emulgelEsansiyel yağ

romatoid artrit

Rosmarinus officinalis

topikal emüljel

Sayı

Makale detayları

Yazarlar: Tilbe Çevikelli | Nurdan Tezcan | Umay Merve Güven Bölgen | Serpil Demirci Kayıran

Yayıncı: Ankara University

Ana Başlıklar: Farmasotik Botanik | İlaç Dağıtım Teknolojileri

Dergi: Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.91-102

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001333046

pISSN: 1015-3918

Sayı

Yazarlar:

Tilbe Çevikelli | Nurdan Tezcan | Umay Merve Güven Bölgen | Serpil Demirci Kayıran

Yayıncı:

Ankara University

Ana Başlıklar:

Farmasotik Botanik | İlaç Dağıtım Teknolojileri

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 1, pp.91-102

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001333046

pISSN:

1015-3918