Relationship Between Hemoglobin, Albumin, Lymphocyte and Platelet (HALP) Score and Geriatric Nutritional Risk Index (GNRI) and Prognosis in Patients Over 75 Years of Age with Metastatic Gastric Cancer

Serkan Menekşe; Engin Kut

Makale detayları

Relationship Between Hemoglobin, Albumin, Lymphocyte and Platelet (HALP) Score and Geriatric Nutritional Risk Index (GNRI) and Prognosis in Patients Over 75 Years of Age with Metastatic Gastric Cancer

Yazarlar:

Serkan Menekşe | Engin Kut

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Batı Karadeniz Tıp Dergisi Vol.7 Issue 1, pp.38-44

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288830

pISSN:

2822-4302

Anahtar kelimeler:

Özet:

 Aim: Gastric cancer GC is a common cancer with high mortality. Stage is the most important predictor of prognosis. But the clinical course of patients who are at the same stage may be different. Therefore, other prognostic markers other than stage are needed. Hemoglobin, albumin, lymphocyte and platelet HALP score and geriatric nutritional risk index GNRI related with prognosis in many malignancies, but their relationship to prognosis in patients with GC with advanced age is unknown. For this reason, we retrospectively analyzed patients older than 75 years, receiving chemotherapy, and metastatic GC. Material and Methods: We retrospectively analyzed 145 patients with metastatic gastric cancer, older than 75 years, receiving chemotherapy in secondary level state hospital between 2009 and 2022. Patients gender, age, Eastern Cooperative Oncology Group ECOG performance score, diagnosis dates, follow-up visits, albumin, hemoglobin, lactate dehydrogenase LDH levels, white blood cell, neutrophil, lymphocyte and platelet count, weight kg, height cm values were examined. Using these values, HALP score, GNRI, and overall survival OS were calculated. Then, the relationship of these parameters with OS was analyzed retrospectively. Results: The median overall survival OS was 8.1 95 Confidence interval CI, 7.07  9.13 months. In multivariate analysis, GNRI 0.035 and HALP p0.001 were associated with survival time. Median OS was 4.5 95 C,3.77-5.24  months in the low HALP group, and 10.2 95 CI, 9.04- 11.36  months in the high HALP group p0.001. Median OS was 6.2 95 CI, 4.25-8.14 months in the low GNRI group and 8.6 95 CI, 7.92-9.27 months in the high GNRI group. Conclusion: GNRI and HALP score are associated with survival in metastatic GC patients older than 75 years. GNRI and HALP score can be used as an easy, cheap and practical method for follow-up, treatment and prognosis in elderly patients with metastatic GC.

 Aim: Gastric cancer GC is a common cancer with high mortality. Stage is the most important predictor of prognosis. But the clinical course of patients who are at the same stage may be different. Therefore, other prognostic markers other than stage are needed. Hemoglobin, albumin, lymphocyte and platelet HALP score and geriatric nutritional risk index GNRI related with prognosis in many malignancies, but their relationship to prognosis in patients with GC with advanced age is unknown. For this reason, we retrospectively analyzed patients older than 75 years, receiving chemotherapy, and metastatic GC. Material and Methods: We retrospectively analyzed 145 patients with metastatic gastric cancer, older than 75 years, receiving chemotherapy in secondary level state hospital between 2009 and 2022. Patients gender, age, Eastern Cooperative Oncology Group ECOG performance score, diagnosis dates, follow-up visits, albumin, hemoglobin, lactate dehydrogenase LDH levels, white blood cell, neutrophil, lymphocyte and platelet count, weight kg, height cm values were examined. Using these values, HALP score, GNRI, and overall survival OS were calculated. Then, the relationship of these parameters with OS was analyzed retrospectively. Results: The median overall survival OS was 8.1 95 Confidence interval CI, 7.07  9.13 months. In multivariate analysis, GNRI 0.035 and HALP p0.001 were associated with survival time. Median OS was 4.5 95 C,3.77-5.24  months in the low HALP group, and 10.2 95 CI, 9.04- 11.36  months in the high HALP group p0.001. Median OS was 6.2 95 CI, 4.25-8.14 months in the low GNRI group and 8.6 95 CI, 7.92-9.27 months in the high GNRI group. Conclusion: GNRI and HALP score are associated with survival in metastatic GC patients older than 75 years. GNRI and HALP score can be used as an easy, cheap and practical method for follow-up, treatment and prognosis in elderly patients with metastatic GC.

 Aim: Gastric cancer GC is a common cancer with high mortality. Stage is the most important predictor of prognosis. But the clinical course of patients who are at the same stage may be different. Therefore, other prognostic markers other than stage are needed. Hemoglobin, albumin, lymphocyte and platelet HALP score and geriatric nutritional risk index GNRI related with prognosis in many malignancies, but their relationship to prognosis in patients with GC with advanced age is unknown. For this reason, we retrospectively analyzed patients older than 75 years, receiving chemotherapy, and metastatic GC. Material and Methods: We retrospectively analyzed 145 patients with metastatic gastric cancer, older than 75 years, receiving chemotherapy in secondary level state hospital between 2009 and 2022. Patients gender, age, Eastern Cooperative Oncology Group ECOG performance score, diagnosis dates, follow-up visits, albumin, hemoglobin, lactate dehydrogenase LDH levels, white blood cell, neutrophil, lymphocyte and platelet count, weight kg, height cm values were examined. Using these values, HALP score, GNRI, and overall survival OS were calculated. Then, the relationship of these parameters with OS was analyzed retrospectively. Results: The median overall survival OS was 8.1 95 Confidence interval CI, 7.07  9.13 months. In multivariate analysis, GNRI 0.035 and HALP p0.001 were associated with survival time. Median OS was 4.5 95 C,3.77-5.24  months in the low HALP group, and 10.2 95 CI, 9.04- 11.36  months in the high HALP group p0.001. Median OS was 6.2 95 CI, 4.25-8.14 months in the low GNRI group and 8.6 95 CI, 7.92-9.27 months in the high GNRI group. Conclusion: GNRI and HALP score are associated with survival in metastatic GC patients older than 75 years. GNRI and HALP score can be used as an easy, cheap and practical method for follow-up, treatment and prognosis in elderly patients with metastatic GC.

 Amaç: Mide kanseri MK sık görülen ve mortalitesi yüksek bir kanserdir. Evre, prognozun en önemli belirleyicisidir. Ancak aynı evrede olan hastaların klinik seyri farklı olabilir. Bu nedenle evre dışında başka prognostik belirteçlere ihtiyaç vardır. Hemoglobin, albümin, lenfosit ve trombosit HALP skoru ve geriatrik nütrisyonel risk indeksi GNRI birçok malignitede prognoz ile ilişkilidir, ancak ileri yaştaki mide kanserli hastalarda prognozla ilişkisi bilinmemektedir. Bu nedenle metastatik, 75 yaş üstü, kemoterapi alan mide kanserli hastaları retrospektif olarak inceledik. Gereç ve Yöntemler: İkinci basamak bir devlet hastanesinde 2009-2022 yılları arasında kemoterapi alan, 75 yaş üstü metastatik mide kanserli 145 hasta retrospektif olarak incelendi. Hastaların cinsiyeti, yaşı, Eastern Cooperative Oncology Group ECOG performans skoru, tanı tarihleri, kontrole geliş tarihleri, albümin seviyeleri, hemoglobin, laktat dehidrogenaz LDH, beyaz küre sayısı, nötrofil, lenfosit ve trombosit sayısı, ağırlık kg, boy cm değerleri incelendi. Bu değerler kullanarak HALP skoru, GNRI, genel sağkalım OS hesaplandı. ardından bu parametrelerin OS ile ilişkisi retrospektif olarak analiz edildi. Bulgular: Medyan genel sağkalım OS 8.1 95 Güven aralığı GA, 7.07  9.13 aydı. Çok değişkenli analizde, GNRI 0.035 ve HALP skoru p0.001 sağkalım süresi ile ilişkiliydi. Medyan OS, düşük HALP grubunda 4,5 95 C,3.77-5.24  ay ve yüksek HALP grubunda 10.2 95 CI, 9.04- 11.36  ay saptandı p0.001. Medyan OS, düşük GNRI grubunda 6.2 95 GA, 4.25-8.14 ay ve yüksek GNRI grubunda 8.6 95 GA, 7.92-9.27 ay saptandı. Sonuç: GNRI ve HALP skoru, 75 yaş üstü metastatik, mide kanserli hastalarda sağkalım süresi ile ilişkilidir. Metastatik mide kanserli yaşlı hastalarda takip stratejisi geliştirmek, tedavi planlamak ve prognoz belirlemek için kolay, ucuz ve pratik bir yöntem olarak kullanılabilir.

Makale detayları

Relationship Between Hemoglobin, Albumin, Lymphocyte and Platelet (HALP) Score and Geriatric Nutritional Risk Index (GNRI) and Prognosis in Patients Over 75 Years of Age with Metastatic Gastric Cancer

Yazarlar:

Serkan Menekşe | Engin Kut

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Batı Karadeniz Tıp Dergisi Vol.7 Issue 1, pp.38-44

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288830

pISSN:

2822-4302

Elderly gastric cancer

HALP score

GNRI

Geriatric nutritional risk index

prognosisGNRI

Yaşlı mide kanseri

HALP skoru

GNRI

Geriatrik nutrisyonel risk indeksi

prognoz

Sayı

Makale detayları

Yazarlar: Serkan Menekşe | Engin Kut

Yayıncı: Zonguldak Bulent Ecevit University

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Batı Karadeniz Tıp Dergisi Vol.7 Issue 1, pp.38-44

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001288830

pISSN: 2822-4302

Sayı

Yazarlar:

Serkan Menekşe | Engin Kut

Yayıncı:

Zonguldak Bulent Ecevit University

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Batı Karadeniz Tıp Dergisi Vol.7 Issue 1, pp.38-44

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288830

pISSN:

2822-4302