Evaluation of TNF-α, Apelin and Visfatin in a sample of Iraqi patients with newly diagnosed Type2 Diabetes Mellitus

N.A.

Makale detayları

Evaluation of TNF-α, Apelin and Visfatin in a sample of Iraqi patients with newly diagnosed Type2 Diabetes Mellitus

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.860-869

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346652

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Type 2 diabetes mellitus, previously referred to as Noninsulin-dependent diabetes or adult-onset diabetes, accounts for 9095  of all diabetes. This type involves people who suffer from relative rather than absolute insulin deficiency and suffer from peripheral insulin resistances. The present study aimed to detect serum marker in newly diagnosed type two diabetic mellitus patients in Baghdad province through evaluation of Tumor necrosis factor alpha, Apelin and Visfatin levels. In the current study, 140 participants were recruited and grouped into: patients group 70 patients with newly diagnosed T2DM, and 70 individuals as apparently healthy control group. In the current study, age and sex matched healthy individuals were enrolled. Results showed the serum level of TNF-α, Apelin and Visfatin were estimated by the use of ELISA technique. Furthermore, the mean serum level of TNF-α, Apelin and Visfatin in T2DM patients was 366.08 76.99 pgml, 96.61 46.62 pgml and 9.59 3.62ngml, respectively, which was higher than that of healthy subjects 175.86 9.92pgml , 15.67 1.74 pgml and 2.15 0.33ngml, respectively with highly significant differences P0.0001. Therefore, TNF-α, Visfatin and Apelin can be applies as a diagnostic biomarker and as useful tools for predict ion and prevention of pre DM complications.

 Type 2 diabetes mellitus, previously referred to as Noninsulin-dependent diabetes or adult-onset diabetes, accounts for 9095  of all diabetes. This type involves people who suffer from relative rather than absolute insulin deficiency and suffer from peripheral insulin resistances. The present study aimed to detect serum marker in newly diagnosed type two diabetic mellitus patients in Baghdad province through evaluation of Tumor necrosis factor alpha, Apelin and Visfatin levels. In the current study, 140 participants were recruited and grouped into: patients group 70 patients with newly diagnosed T2DM, and 70 individuals as apparently healthy control group. In the current study, age and sex matched healthy individuals were enrolled. Results showed the serum level of TNF-α, Apelin and Visfatin were estimated by the use of ELISA technique. Furthermore, the mean serum level of TNF-α, Apelin and Visfatin in T2DM patients was 366.08 76.99 pgml, 96.61 46.62 pgml and 9.59 3.62ngml, respectively, which was higher than that of healthy subjects 175.86 9.92pgml , 15.67 1.74 pgml and 2.15 0.33ngml, respectively with highly significant differences P0.0001. Therefore, TNF-α, Visfatin and Apelin can be applies as a diagnostic biomarker and as useful tools for predict ion and prevention of pre DM complications.

 Type 2 diabetes mellitus, previously referred to as Noninsulin-dependent diabetes or adult-onset diabetes, accounts for 9095  of all diabetes. This type involves people who suffer from relative rather than absolute insulin deficiency and suffer from peripheral insulin resistances. The present study aimed to detect serum marker in newly diagnosed type two diabetic mellitus patients in Baghdad province through evaluation of Tumor necrosis factor alpha, Apelin and Visfatin levels. In the current study, 140 participants were recruited and grouped into: patients group 70 patients with newly diagnosed T2DM, and 70 individuals as apparently healthy control group. In the current study, age and sex matched healthy individuals were enrolled. Results showed the serum level of TNF-α, Apelin and Visfatin were estimated by the use of ELISA technique. Furthermore, the mean serum level of TNF-α, Apelin and Visfatin in T2DM patients was 366.08 76.99 pgml, 96.61 46.62 pgml and 9.59 3.62ngml, respectively, which was higher than that of healthy subjects 175.86 9.92pgml , 15.67 1.74 pgml and 2.15 0.33ngml, respectively with highly significant differences P0.0001. Therefore, TNF-α, Visfatin and Apelin can be applies as a diagnostic biomarker and as useful tools for predict ion and prevention of pre DM complications.

 Type 2 diabetes mellitus, previously referred to as Noninsulin-dependent diabetes or adult-onset diabetes, accounts for 9095  of all diabetes. This type involves people who suffer from relative rather than absolute insulin deficiency and suffer from peripheral insulin resistances. The present study aimed to detect serum marker in newly diagnosed type two diabetic mellitus patients in Baghdad province through evaluation of Tumor necrosis factor alpha, Apelin and Visfatin levels. In the current study, 140 participants were recruited and grouped into: patients group 70 patients with newly diagnosed T2DM, and 70 individuals as apparently healthy control group. In the current study, age and sex matched healthy individuals were enrolled. Results showed the serum level of TNF-α, Apelin and Visfatin were estimated by the use of ELISA technique. Furthermore, the mean serum level of TNF-α, Apelin and Visfatin in T2DM patients was 366.08 76.99 pgml, 96.61 46.62 pgml and 9.59 3.62ngml, respectively, which was higher than that of healthy subjects 175.86 9.92pgml , 15.67 1.74 pgml and 2.15 0.33ngml, respectively with highly significant differences P0.0001. Therefore, TNF-α, Visfatin and Apelin can be applies as a diagnostic biomarker and as useful tools for predict ion and prevention of pre DM complications.

Makale detayları

Evaluation of TNF-α, Apelin and Visfatin in a sample of Iraqi patients with newly diagnosed Type2 Diabetes Mellitus

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.860-869

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346652

pISSN:

2630-6344

Apelin

Tumors necrosis factor alpha (TNF-α)

Type 2 diabetes mellitus (T2DM)

Visfatin

Sayı

Makale detayları

Evaluation of TNF-α, Apelin and Visfatin in a sample of Iraqi patients with newly diagnosed Type2 Diabetes Mellitus

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Basic Pharmacology

Dergi: Journal of Research in Pharmacy Vol.28 Issue 3, pp.860-869

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346652

pISSN: 2630-6344

Apelin

Tumors necrosis factor alpha (TNF-α)

Type 2 diabetes mellitus (T2DM)

Visfatin

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 3, pp.860-869

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346652

pISSN:

2630-6344