25-Hydroxyvitamin D Levels in Preterm Infants ≤32 Weeks Gestational Age and Respiratory Distress Syndrome

Erbu Yarcı; Emre Baldan

Makale detayları

25-Hydroxyvitamin D Levels in Preterm Infants ≤32 Weeks Gestational Age and Respiratory Distress Syndrome

Yazarlar:

Erbu Yarcı | Emre Baldan

Yayıncı:

Akdeniz University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Akdeniz Tıp Dergisi Vol.9 Issue 3, pp.259-264

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001294275

pISSN:

2687-2781

Anahtar kelimeler:

Özet:

 Objective: The aim of this study was to evaluate neonatal vitamin D status and effect of vitamin D levels on the development of respiratory distress syndrome RDS in preterm infants with a gestational age of  32 weeks. The association between RDS and severity of vitamin D deficiency was secondary outcome of this study. Method: Newborns having a gestational age of 32 weeks with RDS consisted the study group, while newborns hospitalized in the neonatal intensive care unit having 32 weeks of gestational age with no signs of RDS were the control group. Results: During the study period, 122 preterm infants having a gestational age of  32 weeks were included. From these, 56 46 had RDS study group, while 66 54 newborns control group did not have RDS. There was no significant difference between the groups in terms of maternal age, multiple pregnancy, use of antenatal steroid, sex, mode of delivery, maternal age, antenatal steroid use, accompanying maternal diseases and birth season. Median 25-OHD levels of study group and control group were similar 12.3 ngml vs 15.6 ngml; p0.38. The rates of preterm infants having low vitamin D levels 25-OHD level15 ngml did not differ between the groups 3856, 68 vs 3566, 53; p0.09. Conclusions: There is no established optimal 25-OHD level for both term and premature infants. Besides, taking into account possible unfavorable both maternal and neonatal effects of vitamin D deficiency, adequate vitamin D supplementation should be provided in countries where vitamin D deficiency is common.

 Objective: The aim of this study was to evaluate neonatal vitamin D status and effect of vitamin D levels on the development of respiratory distress syndrome RDS in preterm infants with a gestational age of  32 weeks. The association between RDS and severity of vitamin D deficiency was secondary outcome of this study. Method: Newborns having a gestational age of 32 weeks with RDS consisted the study group, while newborns hospitalized in the neonatal intensive care unit having 32 weeks of gestational age with no signs of RDS were the control group. Results: During the study period, 122 preterm infants having a gestational age of  32 weeks were included. From these, 56 46 had RDS study group, while 66 54 newborns control group did not have RDS. There was no significant difference between the groups in terms of maternal age, multiple pregnancy, use of antenatal steroid, sex, mode of delivery, maternal age, antenatal steroid use, accompanying maternal diseases and birth season. Median 25-OHD levels of study group and control group were similar 12.3 ngml vs 15.6 ngml; p0.38. The rates of preterm infants having low vitamin D levels 25-OHD level15 ngml did not differ between the groups 3856, 68 vs 3566, 53; p0.09. Conclusions: There is no established optimal 25-OHD level for both term and premature infants. Besides, taking into account possible unfavorable both maternal and neonatal effects of vitamin D deficiency, adequate vitamin D supplementation should be provided in countries where vitamin D deficiency is common.

 Objective: The aim of this study was to evaluate neonatal vitamin D status and effect of vitamin D levels on the development of respiratory distress syndrome RDS in preterm infants with a gestational age of  32 weeks. The association between RDS and severity of vitamin D deficiency was secondary outcome of this study. Method: Newborns having a gestational age of 32 weeks with RDS consisted the study group, while newborns hospitalized in the neonatal intensive care unit having 32 weeks of gestational age with no signs of RDS were the control group. Results: During the study period, 122 preterm infants having a gestational age of  32 weeks were included. From these, 56 46 had RDS study group, while 66 54 newborns control group did not have RDS. There was no significant difference between the groups in terms of maternal age, multiple pregnancy, use of antenatal steroid, sex, mode of delivery, maternal age, antenatal steroid use, accompanying maternal diseases and birth season. Median 25-OHD levels of study group and control group were similar 12.3 ngml vs 15.6 ngml; p0.38. The rates of preterm infants having low vitamin D levels 25-OHD level15 ngml did not differ between the groups 3856, 68 vs 3566, 53; p0.09. Conclusions: There is no established optimal 25-OHD level for both term and premature infants. Besides, taking into account possible unfavorable both maternal and neonatal effects of vitamin D deficiency, adequate vitamin D supplementation should be provided in countries where vitamin D deficiency is common.

 Amaç: Bu çalışmanın amacı, gebelik yaşı  32 hafta olan prematüre bebeklerde D vitamini durumunu ve D vitamini düzeylerinin respiratuvar distres sendromu RDS gelişimine etkisini değerlendirmektir. RDS ile D vitamini eksikliğinin şiddeti arasındaki ilişki bu çalışmanın ikincil sonucunu oluşturmaktadır. Yöntem: RDSli gebelik yaşı 32 hafta olan yenidoğanlar çalışma grubunu oluştururken, yenidoğan yoğun bakım ünitesinde yatan ve RDS bulgusu olmayan 32 hafta olan yenidoğanlar kontrol grubunu oluşturmakta idi. Bulgular: Çalışma süresi boyunca gebelik yaşı  32 hafta olan 122 erken doğmuş bebek dahil edildi. Bunlardan 56sında 46 RDS çalışma grubu varken, 66 yenidoğanda 54 kontrol grubu RDS saptanmadı. Gruplar arasında anne yaşı, çoğul gebelik, antenatal steroid kullanımı, cinsiyet, doğum şekli, anne yaşı, antenatal steroid kullanımı, eşlik eden anne hastalıkları ve doğum mevsimi açısından anlamlı fark yoktu. Çalışma grubu ve kontrol grubunun medyan 25-OHD seviyeleri benzerdi 12.3 ngmlye karşı 15.6 ngml; p0.38. Gruplar arasında D vitamini düzeyi düşük olan 25-OHD düzeyi 15 ngml erken doğmuş bebeklerin oranları açısından farklılık saptanmadı 3856, 68e karşı 3566, 53; p0,09. Sonuç: Hem zamanında doğan hem de prematüre bebekler için belirlenmiş bir optimal 25-OHD seviyesi yoktur. Buna karşın, D vitamini eksikliğinin hem maternal hem de neonatal olası olumsuz etkileri göz önünde bulundurularak, D vitamini eksikliğinin yaygın olduğu ülkelerde yeterli D vitamini desteği sağlanmalıdır.

Makale detayları

25-Hydroxyvitamin D Levels in Preterm Infants ≤32 Weeks Gestational Age and Respiratory Distress Syndrome

Yazarlar:

Erbu Yarcı | Emre Baldan

Yayıncı:

Akdeniz University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Akdeniz Tıp Dergisi Vol.9 Issue 3, pp.259-264

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001294275

pISSN:

2687-2781

25-hydroxyvitamin D

preterm infant

respiratory distress syndrome25-hidroksivitamin D

preterm bebek

respiratuvar distres sendromu

Sayı

Makale detayları

25-Hydroxyvitamin D Levels in Preterm Infants ≤32 Weeks Gestational Age and Respiratory Distress Syndrome

Yazarlar: Erbu Yarcı | Emre Baldan

Yayıncı: Akdeniz University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Akdeniz Tıp Dergisi Vol.9 Issue 3, pp.259-264

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001294275

pISSN: 2687-2781

25-hydroxyvitamin D

preterm infant

respiratory distress syndrome25-hidroksivitamin D

preterm bebek

respiratuvar distres sendromu

Sayı

Yazarlar:

Erbu Yarcı | Emre Baldan

Yayıncı:

Akdeniz University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Akdeniz Tıp Dergisi Vol.9 Issue 3, pp.259-264

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001294275

pISSN:

2687-2781