Studies on The Synthesis of Fluoxetine and Norfluoxetine and Investigation of their Antioxidant Properties

Nesimi Uludağ

Makale detayları

Studies on The Synthesis of Fluoxetine and Norfluoxetine and Investigation of their Antioxidant Properties

Yazarlar:

Nesimi Uludağ

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Biyomateryaller

Dergi:

Black Sea Journal of Engineering and Science Vol.7 Issue 3, pp.560-565

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001315156

pISSN:

2619-8991

Anahtar kelimeler:

Özet:

 A new, practical and short method has been developed for the synthesis of bicyclic antidepressant drugs norfluoxetine and fluoxetine, which involves the use of epoxidation of easily available sirens as starting materials. This study has found application in the synthesis of these compounds of commercial interest, in the construction of new methods of norfluoxetine and fluoxetine in a short way. Additionally, the antioxidant activity of these two compounds given in the title was evaluated by the CUPRAC copper-reducing antioxidant capacity method method and the TEAC Trolox-Equivalent Antioxidant Capacity coefficient of fluoxetine and norfluoexetin. In this study, the antioxidant properties were investigated for the first time in the literature. At the same time, this method provides advantages in terms of percentage yield, reaction conditions and shortness of the reaction step. Characterization of the synthesized compounds was made by 1H-NMR, 13C-NMR IR and MS-mass spectroscopy.

 A new, practical and short method has been developed for the synthesis of bicyclic antidepressant drugs norfluoxetine and fluoxetine, which involves the use of epoxidation of easily available sirens as starting materials. This study has found application in the synthesis of these compounds of commercial interest, in the construction of new methods of norfluoxetine and fluoxetine in a short way. Additionally, the antioxidant activity of these two compounds given in the title was evaluated by the CUPRAC copper-reducing antioxidant capacity method method and the TEAC Trolox-Equivalent Antioxidant Capacity coefficient of fluoxetine and norfluoexetin. In this study, the antioxidant properties were investigated for the first time in the literature. At the same time, this method provides advantages in terms of percentage yield, reaction conditions and shortness of the reaction step. Characterization of the synthesized compounds was made by 1H-NMR, 13C-NMR IR and MS-mass spectroscopy.

 A new, practical and short method has been developed for the synthesis of bicyclic antidepressant drugs norfluoxetine and fluoxetine, which involves the use of epoxidation of easily available sirens as starting materials. This study has found application in the synthesis of these compounds of commercial interest, in the construction of new methods of norfluoxetine and fluoxetine in a short way. Additionally, the antioxidant activity of these two compounds given in the title was evaluated by the CUPRAC copper-reducing antioxidant capacity method method and the TEAC Trolox-Equivalent Antioxidant Capacity coefficient of fluoxetine and norfluoexetin. In this study, the antioxidant properties were investigated for the first time in the literature. At the same time, this method provides advantages in terms of percentage yield, reaction conditions and shortness of the reaction step. Characterization of the synthesized compounds was made by 1H-NMR, 13C-NMR IR and MS-mass spectroscopy.

 İki halkalı antideprasan ilaç olan norfluoksetin ve fluoksetinin sentezi için, başlangıç materyali olarak kolayca bulunabilen sirenlerin epoksidasyonunun kullanılmasını içeren yeni, pratik ve kısa bir yöntem geliştirilmiştir. Bu çalışma, norfluoksetin ve fluoksetinin kısa bir yolla yeni yöntemlerin yapımında, ticari olarak ilgi gören bu bileşiklerin sentezinde uygulama alanı bulmuştur. Ayrıca, başlıkta verilen bu iki bileşiğin antioksidan aktivitesi CUPRAC bakır indirgeyici antioksidan kapasite yöntemi yöntemi ve fluoksetin ve norfluoeksetinin TEAC Trolox-Eşdeğer Antioksidan Kapasite katsayısı ile değerlendirilmiştir. Bu çalışmada antioksidan özelliğinin araştırılması literatürde ilk defa yapılmıştır. Aynı zamanda, Bu metot ile yüzde verim, reaksiyon şartları ve reaksiyon basamağının kısalığı ile de avantajlar sağlamaktadır. Sentezlenen bileşiklerin karekterizasyonu 1H- NMR, 13C-NMR IR ve MS-kütle spektroskopisi ile yapılmıştır.

Makale detayları

Studies on The Synthesis of Fluoxetine and Norfluoxetine and Investigation of their Antioxidant Properties

Yazarlar:

Nesimi Uludağ

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Biyomateryaller

Dergi:

Black Sea Journal of Engineering and Science Vol.7 Issue 3, pp.560-565

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001315156

pISSN:

2619-8991

Prozac

Antidepressant

Antioxidants

Fluoxetine

EpoxidationProzac

Antidepresan

Antioksidanlar

Fluoksetin

Epoksidasyon

Sayı

Makale detayları

Yazarlar: Nesimi Uludağ

Yayıncı: Karyay Karadeniz Yayımcılık

Ana Başlıklar: Biyomateryaller

Dergi: Black Sea Journal of Engineering and Science Vol.7 Issue 3, pp.560-565

Belge Tipi: Makale

Yayın Tarihi: 5/2024

Belge Dili: Türkçe

Document ID (Org No.): 2001315156

pISSN: 2619-8991

Sayı

Yazarlar:

Nesimi Uludağ

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Biyomateryaller

Dergi:

Black Sea Journal of Engineering and Science Vol.7 Issue 3, pp.560-565

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001315156

pISSN:

2619-8991