Evaluation of some blood parameters in the experimental autoimmune encephalomyelitis mouse model

Gökçen GÜVENÇ; Gözde ARSLAN; Mehmet KARAÇAY; Diğdem YÖYEN ERMİŞ; Efe ÖZOĞLU; Barbaros ORAL; Murat YALÇIN

doi:https://doi.org/10.30782/jrvm.936948

Makale detayları

Evaluation of some blood parameters in the experimental autoimmune encephalomyelitis mouse model

Yazarlar:

Gökçen GÜVENÇ | Gözde ARSLAN | Mehmet KARAÇAY | Diğdem YÖYEN ERMİŞ | Efe ÖZOĞLU | Barbaros ORAL | Murat YALÇIN

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Hayvancılık

Dergi:

Journal of Research in Veterinary Medicine 2021 Vol.40 Issue 2, pp.93-97

Belge Tipi:

Makale

Yayın Tarihi:

12/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000493853

Sıklık:

İki Yıllık

eISSN:

2667-6745

DOI:

https://doi.org/10.30782/jrvm.936948

Özet:

 

Multiple sclerosis (MS) is a chronic neuroinflammatory demyelinating disorder of the central nervous system with unclear exact etiology. The experimental autoimmune encephalomyelitis (EAE) model in C57BL/6 mice is the most common animal model for MS sharing many clinical and pathophysiological features to expand our knowledge on the pathophysiology of the disease and to develop novel treatment strategies. The current study was planned to evaluate the effect of EAE on hematologic and plasma total protein and albumin levels in C57BL/6 mice.
EAE was induced with myelin oligodendrocyte glycoprotein (MOG35-55) peptide in the female C57BL/6 mice. The EAE clinically caused paralyzed tail, hind limb paresis, and uncoordinated movement in the mice. The EAE-induced mice hematologically had a mild increase in white blood cell count without altering neutrophil-lymphocyte ratio but no change in vital hematological parameters such as red blood cell count, packed cell volume, and hemoglobin level. Moreover, the EAE produced a rise in the plasma total protein level and an attenuation in plasma albumin level in the mice.
In conclusion, our findings show that the EAE model in mice might not cause any significant change hematologically, except a slight increase in the white blood cell count, and might produce changes in the plasma protein level. The EAE-induced blood parameter effects, as the findings of the current study, could take consideration in terms of understanding the pathophysiology of the disease and developing a novel therapeutic approach for the disease.

Makale detayları

Evaluation of some blood parameters in the experimental autoimmune encephalomyelitis mouse model

Yazarlar: Gökçen GÜVENÇ | Gözde ARSLAN | Mehmet KARAÇAY | Diğdem YÖYEN ERMİŞ | Efe ÖZOĞLU | Barbaros ORAL | Murat YALÇIN

Yayıncı: Bursa Uludağ University

Ana Başlıklar: Hayvancılık

Dergi: Journal of Research in Veterinary Medicine 2021 Vol.40 Issue 2, pp.93-97

Belge Tipi: Makale

Yayın Tarihi: 12/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000493853

Sıklık: İki Yıllık

eISSN: 2667-6745

DOI: https://doi.org/10.30782/jrvm.936948

Sayı

Yazarlar:

Gökçen GÜVENÇ | Gözde ARSLAN | Mehmet KARAÇAY | Diğdem YÖYEN ERMİŞ | Efe ÖZOĞLU | Barbaros ORAL | Murat YALÇIN

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Hayvancılık

Dergi:

Journal of Research in Veterinary Medicine 2021 Vol.40 Issue 2, pp.93-97

Belge Tipi:

Makale

Yayın Tarihi:

12/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000493853

Sıklık:

İki Yıllık

eISSN:

2667-6745

DOI:

https://doi.org/10.30782/jrvm.936948